(14 nodes) Alcohol biosynthetic process network (Shinella sp. HZN7)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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Predicted Interactions

gene neighborhood

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protein homology

Your Input:
	shn_20430	Zinc-dependent alcohol dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (346 aa)
	shn_22330	Bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (269 aa)
	shn_21220	Glyoxalase; Derived by automated computational analysis using gene prediction method: Protein Homology. (141 aa)
	dxs	1-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (641 aa)
	shn_09360	Di-trans,poly-cis-decaprenylcistransferase; Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids. (248 aa)
	shn_09990	Phosphoglycolate phosphatase, bacterial; Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress. Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family. (224 aa)
	shn_10195	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (313 aa)
	shn_12460	Alcohol dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (346 aa)
	thiC	Phosphomethylpyrimidine synthase ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. (607 aa)
	shn_16240	Thiamine biosynthesis protein ThiS; Derived by automated computational analysis using gene prediction method: Protein Homology. (65 aa)
	thiG	Thiazole synthase; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (257 aa)
	thiE	Thiamine-phosphate diphosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (211 aa)
	shn_16925	D-arabinose dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (350 aa)
	shn_19365	4a-hydroxytetrahydrobiopterin dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology. (102 aa)

Your Current Organism:

Shinella sp. HZN7

NCBI taxonomy Id: 879274
Other names: S. sp. HZN7

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
dxs	shn_09360	shn_04070	shn_09360	1-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily.	Di-trans,poly-cis-decaprenylcistransferase; Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.	0.412
dxs	shn_16240	shn_04070	shn_16240	1-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily.	Thiamine biosynthesis protein ThiS; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.621
dxs	thiG	shn_04070	shn_16245	1-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily.	Thiazole synthase; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.	0.972
shn_09360	dxs	shn_09360	shn_04070	Di-trans,poly-cis-decaprenylcistransferase; Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.	1-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily.	0.412
shn_09990	shn_19365	shn_09990	shn_19365	Phosphoglycolate phosphatase, bacterial; Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress. Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family.	4a-hydroxytetrahydrobiopterin dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.405
shn_10195	shn_16240	shn_10195	shn_16240	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Thiamine biosynthesis protein ThiS; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.848
shn_10195	shn_21220	shn_10195	shn_21220	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Glyoxalase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.447
shn_10195	shn_22330	shn_10195	shn_22330	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.847
shn_10195	thiC	shn_10195	shn_16230	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Phosphomethylpyrimidine synthase ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.	0.877
shn_10195	thiG	shn_10195	shn_16245	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Thiazole synthase; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.	0.891
shn_16240	dxs	shn_16240	shn_04070	Thiamine biosynthesis protein ThiS; Derived by automated computational analysis using gene prediction method: Protein Homology.	1-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily.	0.621
shn_16240	shn_10195	shn_16240	shn_10195	Thiamine biosynthesis protein ThiS; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.848
shn_16240	shn_22330	shn_16240	shn_22330	Thiamine biosynthesis protein ThiS; Derived by automated computational analysis using gene prediction method: Protein Homology.	Bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.925
shn_16240	thiC	shn_16240	shn_16230	Thiamine biosynthesis protein ThiS; Derived by automated computational analysis using gene prediction method: Protein Homology.	Phosphomethylpyrimidine synthase ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.	0.964
shn_16240	thiE	shn_16240	shn_16250	Thiamine biosynthesis protein ThiS; Derived by automated computational analysis using gene prediction method: Protein Homology.	Thiamine-phosphate diphosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family.	0.991
shn_16240	thiG	shn_16240	shn_16245	Thiamine biosynthesis protein ThiS; Derived by automated computational analysis using gene prediction method: Protein Homology.	Thiazole synthase; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.	0.999
shn_19365	shn_09990	shn_19365	shn_09990	4a-hydroxytetrahydrobiopterin dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Phosphoglycolate phosphatase, bacterial; Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress. Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family.	0.405
shn_21220	shn_10195	shn_21220	shn_10195	Glyoxalase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.447
shn_21220	thiE	shn_21220	shn_16250	Glyoxalase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Thiamine-phosphate diphosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family.	0.447
shn_22330	shn_10195	shn_22330	shn_10195	Bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.847