(5 nodes) DnaJ domain network (Shinella sp. HZN7)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	shn_04205	Molecular chaperone DnaJ; Derived by automated computational analysis using gene prediction method: Protein Homology. (353 aa)
	shn_10210	Molecular chaperone DnaJ; Derived by automated computational analysis using gene prediction method: Protein Homology. (201 aa)
	shn_11815	Molecular chaperone DjlA; Derived by automated computational analysis using gene prediction method: Protein Homology. (246 aa)
	shn_17645	Molecular chaperone DnaJ; Derived by automated computational analysis using gene prediction method: Protein Homology. (207 aa)
	dnaJ	Molecular chaperone DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, [...] (376 aa)