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hisC hisC APF18547.1 APF18547.1 trpE trpE APF18648.1 APF18648.1 trpD trpD trpC trpC trpF trpF trpB trpB trpA trpA APF19449.1 APF19449.1 APF19450.1 APF19450.1 aroE aroE APF19520.1 APF19520.1 APF19544.1 APF19544.1 APF19589.1 APF19589.1 APF19590.1 APF19590.1 aroQ aroQ aroB aroB aroK aroK aroC aroC
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Your Input:
hisChisC histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (361 aa)
APF18547.13-deoxy-D-arabinoheptulosonate-7-phosphate synthase. (562 aa)
trpEAnthranilate synthase component 1; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] (494 aa)
APF18648.1Anthranilate synthase component 2/para-aminobenzoate synthetase component 2. (195 aa)
trpDtrpD anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (336 aa)
trpCtrpC indole-3-glycerol phosphate synthase; Belongs to the TrpC family. (270 aa)
trpFtrpF phosphoribosylanthranilate isomerase; Belongs to the TrpF family. (217 aa)
trpBtrpB tryptophan synthase, beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (403 aa)
trpAtrpA tryptophan synthase, alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (262 aa)
APF19449.1Chorismate binding enzyme. (433 aa)
APF19450.1Anthranilate phosphoribosyltransferase/anthranilate synthase component 2. (197 aa)
aroEaroE shikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (279 aa)
APF19520.13-phosphoshikimate 1-carboxyvinyltransferase. (420 aa)
APF19544.1Chorismate mutase. (101 aa)
APF19589.1Prephenate dehydrogenase. (348 aa)
APF19590.13-deoxy-D-arabinoheptulosonate-7-phosphate synthase. (344 aa)
aroQaroQ 3-dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (142 aa)
aroBaroB 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (362 aa)
aroKaroK shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (186 aa)
aroCaroC chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (387 aa)
Your Current Organism:
Caldithrix abyssi
NCBI taxonomy Id: 880073
Other names: C. abyssi DSM 13497, Caldithrix abyssi DSM 13497, Caldithrix abyssi LF13, Caldithrix abyssi str. DSM 13497, Caldithrix abyssi strain DSM 13497
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