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Cabys_82 Cabys_82 mgsA mgsA Cabys_964 Cabys_964 APF18082.1 APF18082.1 hutU hutU nth nth fumC fumC Cabys_172 Cabys_172 Cabys_173 Cabys_173 trpB trpB trpA trpA APF17871.1 APF17871.1 APF17793.1 APF17793.1 APF18870.1 APF18870.1 APF18891.1 APF18891.1 APF18908.1 APF18908.1 APF19077.1 APF19077.1 APF19079.1 APF19079.1 APF19152.1 APF19152.1 nnrE nnrE APF19380.1 APF19380.1 APF19419.1 APF19419.1 APF19425.1 APF19425.1 eno eno APF19946.1 APF19946.1 APF19947.1 APF19947.1 ilvD ilvD mqnA mqnA APF20065.1 APF20065.1 APF20110.1 APF20110.1 aroQ aroQ aroB aroB aroC aroC APF20726.1 APF20726.1 APF20574.1 APF20574.1 APF20650.1 APF20650.1 APF20727.1 APF20727.1 trpB-2 trpB-2 murQ murQ vanZ vanZ Cabys_530 Cabys_530 Cabys_582 Cabys_582 Cabys_587 Cabys_587 Cabys_634 Cabys_634
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Cabys_82Aconitase. (755 aa)
mgsAmgsA methylglyoxal synthase; Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate. (145 aa)
Cabys_964Secondary thiamine-phosphate synthase enzyme. (143 aa)
APF18082.16-pyruvoyltetrahydropterin/6- carboxytetrahydropterin synthase. (121 aa)
hutUhutU urocanate hydratase; Catalyzes the conversion of urocanate to 4-imidazolone-5- propionate. (675 aa)
nthNth DNA-(apurinic or apyrimidinic site) lyase; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (231 aa)
fumCfumC fumarase, class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (461 aa)
Cabys_172Fumarate hydratase, class I. (194 aa)
Cabys_173Fumarate hydratase, class I. (289 aa)
trpBtrpB tryptophan synthase, beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (403 aa)
trpAtrpA tryptophan synthase, alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (262 aa)
APF17871.1Hypothetical protein. (317 aa)
APF17793.1Carbonic anhydrase. (276 aa)
APF18870.1Threonine synthase. (425 aa)
APF18891.1Glycopeptide antibiotics resistance protein. (468 aa)
APF18908.1Secondary thiamine-phosphate synthase enzyme. (139 aa)
APF19077.1DNA-(apurinic or apyrimidinic site) lyase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. (272 aa)
APF19079.1dTDP-glucose 4,6-dehydratase; Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily. (337 aa)
APF19152.1methylglutaconyl-CoA hydratase; Belongs to the enoyl-CoA hydratase/isomerase family. (261 aa)
nnrENAD(P)H-hydrate epimerase; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of bot [...] (524 aa)
APF19380.1Homoaconitate hydratase family protein/3-isopropylmalate dehydratase, large subunit/3-isopropylmalate dehydratase, small subunit. (607 aa)
APF19419.1Porphobilinogen synthase; Belongs to the ALAD family. (325 aa)
APF19425.1Uroporphyrinogen III methyltransferase / synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. (263 aa)
enoEno enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (427 aa)
APF19946.13-isopropylmalate/(R)-2-methylmalate dehydratase small subunit; Belongs to the LeuD family. (217 aa)
APF19947.13-isopropylmalate dehydratase, large subunit; Belongs to the aconitase/IPM isomerase family. (432 aa)
ilvDilvD dihydroxyacid dehydratase; Belongs to the IlvD/Edd family. (561 aa)
mqnAmqnA chorismate dehydratase; Catalyzes the dehydration of chorismate into 3-[(1- carboxyvinyl)oxy]benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2). (289 aa)
APF20065.1L-threonine synthase. (433 aa)
APF20110.1Short chain enoyl-CoA hydratase; Belongs to the enoyl-CoA hydratase/isomerase family. (261 aa)
aroQaroQ 3-dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (142 aa)
aroBaroB 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (362 aa)
aroCaroC chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (387 aa)
APF20726.16-pyruvoyltetrahydropterin/6- carboxytetrahydropterin synthase. (141 aa)
APF20574.1Carbamoyl-phosphate synthase large subunit. (1065 aa)
APF20650.12-methylcitrate dehydratase. (457 aa)
APF20727.16-pyruvoyltetrahydropterin/6- carboxytetrahydropterin synthase. (138 aa)
trpB-2trpB tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (454 aa)
murQmurQ N-acetylmuramic acid 6-phosphate etherase; Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D- lactate. (311 aa)
vanZVanZ like family protein. (139 aa)
Cabys_530Membrane-bound lytic murein transglycosylase F. (249 aa)
Cabys_582Homoaconitase. (657 aa)
Cabys_5874a-hydroxytetrahydrobiopterin dehydratase. (93 aa)
Cabys_634Secondary thiamine-phosphate synthase enzyme. (132 aa)
Your Current Organism:
Caldithrix abyssi
NCBI taxonomy Id: 880073
Other names: C. abyssi DSM 13497, Caldithrix abyssi DSM 13497, Caldithrix abyssi LF13, Caldithrix abyssi str. DSM 13497, Caldithrix abyssi strain DSM 13497
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