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| | fba | Fructose-bisphosphate aldolase, class I. (354 aa) |
| | APF17779.1 | Sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family. (218 aa) |
| | APF17810.1 | O-acetylhomoserine sulfhydrylase. (433 aa) |
| | metX | metX homoserine O-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. (372 aa) |
| | APF17812.1 | Aspartate kinase; Belongs to the aspartokinase family. (456 aa) |
| | APF17814.1 | Acyl-ACP thioesterase. (253 aa) |
| | argR | argR transcriptional regulator, ArgR family; Regulates arginine biosynthesis genes. (148 aa) |
| | APF17846.1 | Acyl carrier protein. (81 aa) |
| | Cabys_110 | methylmalonyl-CoA epimerase. (137 aa) |
| | Cabys_111 | acetyl-CoA carboxylase carboxyltransferase subunit beta /acetyl-CoA carboxylase carboxyltransferase subunit alpha /propionyl-CoA carboxylase carboxyltransferase subunit. (516 aa) |
| | APF17872.1 | Pyruvate phosphate dikinase, PEP/pyruvate binding domain. (822 aa) |
| | Cabys_113 | Biotin-requiring enzyme. (159 aa) |
| | APF17904.1 | Glutamate dehydrogenase (NADP); Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (453 aa) |
| | APF17907.1 | Glutamate dehydrogenase (NAD(P)+); Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (428 aa) |
| | pyrG | pyrG CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (537 aa) |
| | pfp | Pfp 6-phosphofructokinase 1; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. (445 aa) |
| | APF17980.1 | Arginine decarboxylase. (181 aa) |
| | APF17981.1 | Agmatinase; Belongs to the arginase family. (283 aa) |
| | APF17991.1 | Succinyl-diaminopimelate desuccinylase. (412 aa) |
| | APF18005.1 | NADPH2:quinone reductase. (340 aa) |
| | pfkA | pfkA 6-phosphofructokinase 1; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily. (365 aa) |
| | APF18052.1 | 5-methyltetrahydrofolate--homocysteine methyltransferase. (296 aa) |
| | APF18054.1 | Ectoine hydroxylase-related dioxygenase, phytanoyl-CoA dioxygenase (PhyH) family. (284 aa) |
| | APF18088.1 | Methionine-gamma-lyase. (394 aa) |
| | acpP | acpP acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. (80 aa) |
| | APF18108.1 | Cysteine synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (304 aa) |
| | APF18109.1 | Serine O-acetyltransferase. (281 aa) |
| | APF18121.1 | D-lactate dehydrogenase. (942 aa) |
| | acyl | Acyl transferase domain-containing protein. (1554 aa) |
| | APF18150.1 | Amino acid adenylation domain-containing protein. (3868 aa) |
| | APF18152.1 | Pyruvate phosphate dikinase; Belongs to the PEP-utilizing enzyme family. (893 aa) |
| | hutU | hutU urocanate hydratase; Catalyzes the conversion of urocanate to 4-imidazolone-5- propionate. (675 aa) |
| | APF18175.1 | 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase. (133 aa) |
| | gltX | gltX glutamyl-tRNA synthetase/nondiscriminating glutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. (477 aa) |
| | cysS | cysS cysteinyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (484 aa) |
| | APF18292.1 | AMP nucleosidase. (268 aa) |
| | APF18301.1 | Glutamate dehydrogenase (NAD/NADP); Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (413 aa) |
| | APF18302.1 | Response regulator receiver domain-containing protein. (1000 aa) |
| | Cabys_156 | Pyruvate kinase; Belongs to the pyruvate kinase family. (474 aa) |
| | ileS | ileS Isoleucyl-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily. (1095 aa) |
| | APF18381.1 | Hypothetical protein. (568 aa) |
| | Cabys_165 | 7, 8-dihydropterin-6-yl-methyl-4-(beta-D- ribofuranosyl)aminobenzene 5'-phosphate synthase. (278 aa) |
| | glyQS | glyQS glycyl-tRNA synthetase; Catalyzes the attachment of glycine to tRNA(Gly). Belongs to the class-II aminoacyl-tRNA synthetase family. (436 aa) |
| | APF18408.1 | D-cysteine desulfhydrase. (315 aa) |
| | panD | panD L-aspartate 1-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. (123 aa) |
| | APF18457.1 | Aspartate semialdehyde dehydrogenase; Belongs to the aspartate-semialdehyde dehydrogenase family. (354 aa) |
| | fumC | fumC fumarase, class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (461 aa) |
| | APF18461.1 | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridin epyrophosphokinase; 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine diphosphokinase/dihydroneopterin aldolase / 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase. (160 aa) |
| | hisC | hisC histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (361 aa) |
| | APF18481.1 | L-amino acid N-acyltransferase YncA. (202 aa) |
| | APF18482.1 | Argininosuccinate synthase. (402 aa) |
| | argC | argC N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (321 aa) |
| | argB | N-acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (256 aa) |
| | APF18485.1 | Acetylornithine deacetylase. (357 aa) |
| | argH | argH argininosuccinate lyase. (448 aa) |
| | APF18488.1 | Glutamate synthase (NADH) large subunit. (1504 aa) |
| | APF18489.1 | Glutamate synthase (NADH) small subunit. (471 aa) |
| | proC | proC pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (273 aa) |
| | APF18497.1 | D-serine deaminase, pyridoxal phosphate-dependent. (375 aa) |
| | APF18522.1 | L-threonine aldolase. (345 aa) |
| | APF18526.1 | Isocitrate dehydrogenase; Belongs to the monomeric-type IDH family. (743 aa) |
| | kamA | KamA family protein. (432 aa) |
| | APF18547.1 | 3-deoxy-D-arabinoheptulosonate-7-phosphate synthase. (562 aa) |
| | APF18555.1 | Methionine-gamma-lyase. (399 aa) |
| | glnS | glnS glutaminyl-tRNA synthetase. (562 aa) |
| | APF18608.1 | Kynurenine formamidase. (214 aa) |
| | APF18636.1 | propionyl-CoA carboxylase carboxyltransferase subunit. (516 aa) |
| | trpD | trpD anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (336 aa) |
| | trpC | trpC indole-3-glycerol phosphate synthase; Belongs to the TrpC family. (270 aa) |
| | trpF | trpF phosphoribosylanthranilate isomerase; Belongs to the TrpF family. (217 aa) |
| | trpB | trpB tryptophan synthase, beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (403 aa) |
| | trpA | trpA tryptophan synthase, alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (262 aa) |
| | APF18661.1 | 2-oxoglutarate dehydrogenase E2 component. (411 aa) |
| | APF18667.1 | Heterodisulfide reductase subunit B. (295 aa) |
| | gcvPA | gcvPA glycine dehydrogenase (decarboxylating) alpha subunit; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. (429 aa) |
| | gcvPB | gcvPB glycine dehydrogenase (decarboxylating) beta subunit; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. (484 aa) |
| | APF18683.1 | Pyridoxal phosphate synthase yaaE subunit. (190 aa) |
| | APF18684.1 | Aminotransferase class-III; acetylornithine/N-succinyldiaminopimelate aminotransferase/acetylornithine/LysW-gamma-L-lysine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (493 aa) |
| | glmS | glmS glucosamine--fructose-6-phosphate aminotransferase (isomerizing); Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. (609 aa) |
| | guaA | guaA GMP synthase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP. (522 aa) |
| | hisA | hisA 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino) imidazole-4-carboxamide isomerase. (247 aa) |
| | hisF | hisF cyclase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (251 aa) |
| | accD | accD acetyl-CoA carboxylase carboxyl transferase subunit beta; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (283 aa) |
| | hisI | hisI phosphoribosyl-ATP pyrophosphatase; In the N-terminal section; belongs to the PRA-CH family. (197 aa) |
| | APF18741.1 | 2-dehydro-3-deoxyphosphooctonate aldolase (KDO 8-P synthase); Belongs to the KdsA family. (291 aa) |
| | APF18771.1 | Asparagine synthase (glutamine-hydrolysing). (658 aa) |
| | acyl-2 | Acyl carrier protein. (85 aa) |
| | APF18778.1 | Long-chain acyl-CoA synthetase. (615 aa) |
| | APF18826.1 | Cysteine desulfurase / selenocysteine lyase; Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine. (446 aa) |
| | APF18831.1 | Glutamine synthetase. (457 aa) |
| | APF18836.1 | Long-chain acyl-CoA synthetase. (597 aa) |
| | APF18844.1 | Aspartate ammonia-lyase. (621 aa) |
| | leuS | leuS leucyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (877 aa) |
| | APF18868.1 | Putative selenium metabolism hydrolase. (403 aa) |
| | APF18869.1 | N-acetylornithine carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. (325 aa) |
| | APF18870.1 | Threonine synthase. (425 aa) |
| | APF18871.1 | Cysteine synthase. (490 aa) |
| | gcvH | gcvH glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (125 aa) |
| | APF18882.1 | acetyl-CoA carboxylase, biotin carboxylase subunit; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (452 aa) |
| | APF18886.1 | Biotin carboxyl carrier protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (170 aa) |
| | APF18945.1 | Amidohydrolase. (386 aa) |
| | APF19014.1 | Glutamate formiminotransferase / formiminotetrahydrofolate cyclodeaminase. (610 aa) |
| | APF19027.1 | 7, 8-dihydropterin-6-yl-methyl-4-(beta-D- ribofuranosyl)aminobenzene 5'-phosphate synthase. (213 aa) |
| | APF19062.1 | Allosteric NADP-dependent malic enzyme. (748 aa) |
| | APF19073.1 | Hypothetical protein. (706 aa) |
| | APF19085.1 | aromatic-L-amino-acid decarboxylase. (474 aa) |
| | hisH | hisH glutamine amidotransferase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (194 aa) |
| | hisC-2 | hisC histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (356 aa) |
| | hisD | hisD histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (442 aa) |
| | hisG | hisG ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (284 aa) |
| | APF19132.1 | L-threonine aldolase. (347 aa) |
| | APF19136.1 | acetyl-CoA C-acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (365 aa) |
| | APF19152.1 | methylglutaconyl-CoA hydratase; Belongs to the enoyl-CoA hydratase/isomerase family. (261 aa) |
| | APF19153.1 | Acetyl-CoA carboxylase, carboxyltransferase component. (556 aa) |
| | APF19160.1 | Tryptophanase. (215 aa) |
| | APF19161.1 | Tryptophanase. (252 aa) |
| | argD | argD acetylornithine aminotransferase/acetylornithine/N-succinyldiaminopimelate aminotransferase. (393 aa) |
| | asnS | asnS asparaginyl-tRNA synthetase. (431 aa) |
| | nadA | nadA quinolinate synthetase; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (347 aa) |
| | APF19218.1 | UDP-glucose dehydrogenase. (445 aa) |
| | gcvT | gcvT aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. (358 aa) |
| | APF19234.1 | L-alanine dehydrogenase. (374 aa) |
| | APF19269.1 | Protein of unknown function (DUF1080). (227 aa) |
| | APF19283.1 | tryptophanyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (325 aa) |
| | nanE | nanE N-acylglucosamine-6-phosphate 2-epimerase; Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N- acetylglucosamine-6-phosphate (GlcNAc-6-P). (235 aa) |
| | Cabys_260 | GMP synthase (glutamine-hydrolysing). (233 aa) |
| | APF19379.1 | Citrate lyase subunit beta / citryl-CoA lyase. (405 aa) |
| | APF19380.1 | Homoaconitate hydratase family protein/3-isopropylmalate dehydratase, large subunit/3-isopropylmalate dehydratase, small subunit. (607 aa) |
| | APF19382.1 | 3-isopropylmalate dehydrogenase. (395 aa) |
| | selD | selD selenophosphate synthase; Synthesizes selenophosphate from selenide and ATP. (352 aa) |
| | folD | folD methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (297 aa) |
| | pheT | pheT phenylalanyl-tRNA synthetase beta subunit; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily. (792 aa) |
| | pheS | pheS phenylalanyl-tRNA synthetase, alpha subunit; Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily. (335 aa) |
| | thrS | thrS threonyl-tRNA synthetase; Catalyzes the attachment of threonine to tRNA(Thr) in a two- step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). (639 aa) |
| | APF19448.1 | Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase. (276 aa) |
| | tpiA | tpiA triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (255 aa) |
| | pgk | Pgk phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (398 aa) |
| | APF19499.1 | 8-amino-7-oxononanoate synthase. (396 aa) |
| | proS | proS prolyl-tRNA synthetase; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). (476 aa) |
| | APF19513.1 | Por secretion system C-terminal sorting domain-containing protein. (451 aa) |
| | aroE | aroE shikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (279 aa) |
| | APF19520.1 | 3-phosphoshikimate 1-carboxyvinyltransferase. (420 aa) |
| | APF19528.1 | Phosphopantothenoylcysteine decarboxylase / phosphopantothenate--cysteine ligase. (353 aa) |
| | dtd | Dtd D-tyrosyl-tRNA(Tyr) deacylase; An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA- based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D- aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl- tRNA entities in vivo and helps enforce protein L-homochirality. Belongs to the DTD family. (146 aa) |
| | APF19544.1 | Chorismate mutase. (101 aa) |
| | APF19589.1 | Prephenate dehydrogenase. (348 aa) |
| | APF19590.1 | 3-deoxy-D-arabinoheptulosonate-7-phosphate synthase. (344 aa) |
| | APF19606.1 | Homoserine O-acetyltransferase; Belongs to the AB hydrolase superfamily. MetX family. (341 aa) |
| | APF19607.1 | Uncharacterized 2Fe-2 and 4Fe-4S clusters-containing protein, contains DUF4445 domain. (627 aa) |
| | eno | Eno enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (427 aa) |
| | APF19631.1 | Long-chain acyl-CoA synthetase. (592 aa) |
| | APF19635.1 | L-asparaginase. (329 aa) |
| | Cabys_291 | 3-ketoacyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (429 aa) |
| | Cabys_292 | Short chain enoyl-CoA hydratase; Belongs to the enoyl-CoA hydratase/isomerase family. (669 aa) |
| | APF19677.1 | Cystathionine beta-synthase. (317 aa) |
| | APF19692.1 | 3-oxoacyl-(acyl-carrier-protein) synthase-3. (329 aa) |
| | APF19715.1 | D-alanine transaminase. (281 aa) |
| | APF19718.1 | Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. (305 aa) |
| | hutH | hutH histidine ammonia-lyase. (512 aa) |
| | APF19753.1 | NADPH-dependent glutamate synthase beta chain. (445 aa) |
| | APF19761.1 | 3-hydroxybutyryl-CoA dehydrogenase. (281 aa) |
| | APF19762.1 | acetyl-CoA C-acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (395 aa) |
| | aspS | aspartyl-tRNA synthetase; Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn); Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily. (584 aa) |
| | acsA | acsA acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (633 aa) |
| | Cabys_308 | Radical SAM additional 4Fe4S-binding SPASM domain-containing protein. (386 aa) |
| | APF19843.1 | Selenocysteine lyase/Cysteine desulfurase. (374 aa) |
| | Cabys_314 | Glyoxylase, beta-lactamase superfamily II. (299 aa) |
| | APF19892.1 | Histidine ammonia-lyase. (507 aa) |
| | APF19895.1 | Homocitrate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (383 aa) |
| | argC-2 | argC N-acetyl-gamma-glutamyl-phosphate reductase; Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (348 aa) |
| | APF19898.1 | Glutamine amidotransferase. (213 aa) |
| | APF19899.1 | acetylglutamate/LysW-gamma-L-alpha-aminoadipate kinase. (263 aa) |
| | argD-2 | argD acetylornithine aminotransferase apoenzyme. (389 aa) |
| | pyrB | pyrB aspartate carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (306 aa) |
| | purF | purF amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (477 aa) |
| | APF19923.1 | Phosphoribosylformylglycinamidine synthase. (272 aa) |
| | APF19924.1 | GMP synthase (glutamine-hydrolysing). (233 aa) |
| | APF19945.1 | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (536 aa) |
| | APF19946.1 | 3-isopropylmalate/(R)-2-methylmalate dehydratase small subunit; Belongs to the LeuD family. (217 aa) |
| | APF19947.1 | 3-isopropylmalate dehydratase, large subunit; Belongs to the aconitase/IPM isomerase family. (432 aa) |
| | leuA | leuA 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (521 aa) |
| | leuB | leuB 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (365 aa) |
| | ilvC | ilvC ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (331 aa) |
| | APF19951.1 | Acetolactate synthase, small subunit. (170 aa) |
| | APF19952.1 | Acetolactate synthase, large subunit. (572 aa) |
| | ilvD | ilvD dihydroxyacid dehydratase; Belongs to the IlvD/Edd family. (561 aa) |
| | APF19981.1 | ACT domain-containing protein. (154 aa) |
| | Cabys_324 | Thiosulfate/3-mercaptopyruvate sulfurtransferase. (369 aa) |
| | APF20003.1 | Homoserine dehydrogenase. (342 aa) |
| | Cabys_326 | 3-mercaptopyruvate sulfurtransferase SseA, contains two rhodanese domains. (327 aa) |
| | APF20012.1 | 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide A dehydrogenase. (344 aa) |
| | APF20013.1 | Homoserine dehydrogenase. (348 aa) |
| | serC | serC phosphoserine aminotransferase apoenzyme; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (361 aa) |
| | lipA | lipA lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (320 aa) |
| | APF20063.1 | Aspartate kinase; Belongs to the aspartokinase family. (467 aa) |
| | thrB | thrB homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (319 aa) |
| | APF20065.1 | L-threonine synthase. (433 aa) |
| | fabH | fabH 3-oxoacyl-(acyl-carrier-protein) synthase-3; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family. (334 aa) |
| | argD-3 | argD ornithine--oxo-acid transaminase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (401 aa) |
| | APF20102.1 | Long-chain acyl-CoA synthetase (AMP-forming). (1596 aa) |
| | APF20110.1 | Short chain enoyl-CoA hydratase; Belongs to the enoyl-CoA hydratase/isomerase family. (261 aa) |
| | tyrS | tyrS tyrosyl-tRNA synthetase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily. (430 aa) |
| | hutI | hutI imidazolonepropionase. (410 aa) |
| | APF20141.1 | Glutamine amidotransferase class-II:Asparagine synthase. (573 aa) |
| | APF20151.1 | Asparagine synthase (glutamine-hydrolysing). (604 aa) |
| | APF20162.1 | Acyl carrier protein. (78 aa) |
| | APF20201.1 | 3-oxoacyl-(acyl-carrier-protein) synthase II; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. (414 aa) |
| | acpP-2 | acpP acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. (80 aa) |
| | APF20204.1 | (Acyl-carrier-protein) S-malonyltransferase. (308 aa) |
| | fabH-2 | fabH 3-oxoacyl-(acyl-carrier-protein) synthase III; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family. (338 aa) |
| | plsX | plsX phosphate:acyl-(acyl carrier protein) acyltransferase; Catalyzes the reversible formation of acyl-phosphate (acyl- PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA. (337 aa) |
| | APF20210.1 | 3-hydroxybutyryl-CoA dehydrogenase. (314 aa) |
| | APF20217.1 | Carbamate kinase; Belongs to the carbamate kinase family. (317 aa) |
| | APF20218.1 | Putative GTPase. (437 aa) |
| | APF20220.1 | Phosphotransferase enzyme family protein. (365 aa) |
| | APF20242.1 | NADPH:quinone reductase. (293 aa) |
| | APF20253.1 | 2-oxoglutarate dehydrogenase E2 component (dihydrolipoamide succinyltransferase). (430 aa) |
| | APF20254.1 | 2-oxoisovalerate dehydrogenase E1 component. (678 aa) |
| | APF20430.1 | Biotin synthase. (351 aa) |
| | APF20433.1 | Aspartate ammonia-lyase. (468 aa) |
| | accA | accA acetyl-CoA carboxylase carboxyltransferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (322 aa) |
| | lysS | lysS lysyl-tRNA synthetase, class II; Belongs to the class-II aminoacyl-tRNA synthetase family. (497 aa) |
| | APF20482.1 | Dihydropteroate synthase. (362 aa) |
| | aroQ | aroQ 3-dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (142 aa) |
| | APF20491.1 | Phosphoribosyl 1,2-cyclic phosphate phosphodiesterase. (255 aa) |
| | aroB | aroB 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (362 aa) |
| | aroK | aroK shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (186 aa) |
| | APF20513.1 | Nucleoside phosphorylase. (199 aa) |
| | aroC | aroC chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (387 aa) |
| | APF20528.1 | Isocitrate dehydrogenase (NAD+). (341 aa) |
| | APF20530.1 | 5,10-methylenetetrahydrofolate reductase (NAD(P)); Belongs to the methylenetetrahydrofolate reductase family. (317 aa) |
| | APF20545.1 | Pyruvate dehydrogenase E2 component (dihydrolipoamide acetyltransferase). (442 aa) |
| | APF20546.1 | Pyruvate dehydrogenase E1 component; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (890 aa) |
| | Cabys_383 | Long-chain acyl-CoA synthetase. (563 aa) |
| | carA | carA carbamoyl-phosphate synthase small subunit; Belongs to the CarA family. (358 aa) |
| | mdh | Mdh malate dehydrogenase (NAD); Catalyzes the reversible oxidation of malate to oxaloacetate. (318 aa) |
| | APF20596.1 | L-ascorbate metabolism protein UlaG, beta-lactamase superfamily; Belongs to the UPF0173 family. (225 aa) |
| | APF20636.1 | Bifunctional phosphoglucose/phosphomannose isomerase. (346 aa) |
| | APF20650.1 | 2-methylcitrate dehydratase. (457 aa) |
| | APF20656.1 | Homoserine dehydrogenase. (436 aa) |
| | APF20657.1 | 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway). (223 aa) |
| | alaS | alaS alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain. (870 aa) |
| | APF20692.1 | Alpha-aminoadipic semialdehyde synthase. (378 aa) |
| | Cabys_398 | Selenocysteine lyase/Cysteine desulfurase. (468 aa) |
| | trpB-2 | trpB tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (454 aa) |
| | Cabys_399 | alanyl-tRNA synthetase. (391 aa) |
| | hisS | hisS histidyl-tRNA synthetase. (421 aa) |
| | APF20849.1 | Long-chain acyl-CoA synthetase. (652 aa) |
| | APF20921.1 | Gluconolactonase. (302 aa) |
| | glyA | glyA serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (430 aa) |
| | murQ | murQ N-acetylmuramic acid 6-phosphate etherase; Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D- lactate. (311 aa) |
| | panB | panB ketopantoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (271 aa) |
| | panC | panC pantothenate synthetase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (284 aa) |
| | argS | argS arginyl-tRNA synthetase. (544 aa) |
| | Cabys_554 | Radical SAM additional 4Fe4S-binding SPASM domain-containing protein. (361 aa) |
| | Cabys_564 | Zinc-regulated TonB-dependent outer membrane receptor. (440 aa) |
| | valS | valS valyl-tRNA synthetase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily. (896 aa) |
| | Cabys_590 | L-proline dehydrogenase. (302 aa) |
| | Cabys_656 | Branched-chain amino acid aminotransferase. (343 aa) |
| | Cabys_667 | Hypothetical protein. (524 aa) |
| | gltX-2 | gltX glutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. (484 aa) |
| | Cabys_704 | Malate dehydrogenase (NAD); Catalyzes the conversion of lactate to pyruvate. (316 aa) |
| | serS | serS seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (467 aa) |
| | Cabys_723 | Glyoxylase, beta-lactamase superfamily II. (208 aa) |
| | Cabys_727 | B3/B4 domain-containing protein (DNA/RNA-binding domain of Phe-tRNA-synthetase). (223 aa) |
| | plsX-2 | plsX phosphate:acyl-(acyl carrier protein) acyltransferase; Catalyzes the reversible formation of acyl-phosphate (acyl- PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA. (349 aa) |
| | lysA | lysA diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (418 aa) |
| | Cabys_743 | Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. (371 aa) |
| | Cabys_77 | Barrel-sandwich domain of CusB or HlyD membrane-fusion. (268 aa) |
| | Cabys_784 | Membrane bound protein complex subunit mbxM. (303 aa) |
| | gpmI | gpmI phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (512 aa) |
| | Cabys_792 | Phosphopantothenoylcysteine decarboxylase. (181 aa) |
| | Cabys_801 | Sulfide dehydrogenase (flavoprotein) subunit SudA. (475 aa) |
| | Cabys_805 | L-ascorbate metabolism protein UlaG, beta-lactamase superfamily. (363 aa) |
| | metG | metG methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. (680 aa) |
| | dapF | dapF diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (273 aa) |
| | pgi | Pgi glucose-6-phosphate isomerase; Belongs to the GPI family. (459 aa) |
| | mtnA | mtnA methylthioribose-1-phosphate isomerase; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). (350 aa) |
| | Cabys_91 | Glyoxylase, beta-lactamase superfamily II. (280 aa) |
| | Cabys_958 | Radical SAM additional 4Fe4S-binding SPASM domain-containing protein. (361 aa) |
| | Cabys_989 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1240 aa) |
| | Cabys_990 | acetyl-CoA carboxylase, biotin carboxylase subunit; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (499 aa) |
| | Cabys_991 | Biotin-requiring enzyme. (182 aa) |
