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| | APF17764.1 | dTDP-4-dehydrorhamnose 3,5-epimerase; Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose. Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family. (182 aa) |
| | APF17810.1 | O-acetylhomoserine sulfhydrylase. (433 aa) |
| | metX | metX homoserine O-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. (372 aa) |
| | APF17812.1 | Aspartate kinase; Belongs to the aspartokinase family. (456 aa) |
| | APF17865.1 | Geranylgeranyl diphosphate synthase, type II; Belongs to the FPP/GGPP synthase family. (286 aa) |
| | APF17885.1 | 1,4-dihydroxy-2-naphthoate octaprenyltransferase. (512 aa) |
| | Cabys_115 | Aspartate aminotransferase. (399 aa) |
| | pfp | Pfp 6-phosphofructokinase 1; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. (445 aa) |
| | APF17982.1 | Alpha-amylase. (708 aa) |
| | APF17988.1 | Lipid kinase, YegS/Rv2252/BmrU family. (302 aa) |
| | pfkA | pfkA 6-phosphofructokinase 1; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily. (365 aa) |
| | APF18052.1 | 5-methyltetrahydrofolate--homocysteine methyltransferase. (296 aa) |
| | APF18055.1 | Uroporphyrinogen decarboxylase; Belongs to the uroporphyrinogen decarboxylase family. (340 aa) |
| | acpP | acpP acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. (80 aa) |
| | APF18099.1 | Glycosyl hydrolase family 1; Belongs to the glycosyl hydrolase 1 family. (426 aa) |
| | APF18108.1 | Cysteine synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (304 aa) |
| | APF18109.1 | Serine O-acetyltransferase. (281 aa) |
| | mbtH | MbtH protein. (78 aa) |
| | APF18152.1 | Pyruvate phosphate dikinase; Belongs to the PEP-utilizing enzyme family. (893 aa) |
| | APF18155.1 | Glycerate 2-kinase. (440 aa) |
| | Cabys_143 | Purine-nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (272 aa) |
| | Cabys_156 | Pyruvate kinase; Belongs to the pyruvate kinase family. (474 aa) |
| | APF18309.1 | Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (671 aa) |
| | tal | Tal transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 3B subfamily. (215 aa) |
| | tal-2 | Tal transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 3B subfamily. (215 aa) |
| | psd | Psd phosphatidylserine decarboxylase; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). (215 aa) |
| | APF18316.1 | CDP-diacylglycerol--serine O-phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (242 aa) |
| | APF18336.1 | Mannose-6-phosphate isomerase, type 1. (405 aa) |
| | APF18338.1 | Aldose 1-epimerase; Converts alpha-aldose to the beta-anomer. (357 aa) |
| | APF18367.1 | Purine-nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (276 aa) |
| | APF18375.1 | Glycosidase. (600 aa) |
| | panD | panD L-aspartate 1-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. (123 aa) |
| | APF18440.1 | Aldehyde dehydrogenase (NAD+); Belongs to the aldehyde dehydrogenase family. (473 aa) |
| | APF18452.1 | 2-oxoglutarate ferredoxin oxidoreductase subunit alpha. (610 aa) |
| | APF18453.1 | 2-oxoglutarate ferredoxin oxidoreductase subunit beta. (345 aa) |
| | APF18457.1 | Aspartate semialdehyde dehydrogenase; Belongs to the aspartate-semialdehyde dehydrogenase family. (354 aa) |
| | fumC | fumC fumarase, class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (461 aa) |
| | Cabys_172 | Fumarate hydratase, class I. (194 aa) |
| | hisC | hisC histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (361 aa) |
| | Cabys_173 | Fumarate hydratase, class I. (289 aa) |
| | APF18482.1 | Argininosuccinate synthase. (402 aa) |
| | argC | argC N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (321 aa) |
| | argB | N-acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (256 aa) |
| | APF18485.1 | Acetylornithine deacetylase. (357 aa) |
| | argH | argH argininosuccinate lyase. (448 aa) |
| | APF18488.1 | Glutamate synthase (NADH) large subunit. (1504 aa) |
| | APF18489.1 | Glutamate synthase (NADH) small subunit. (471 aa) |
| | proC | proC pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (273 aa) |
| | APF18522.1 | L-threonine aldolase. (345 aa) |
| | APF18526.1 | Isocitrate dehydrogenase; Belongs to the monomeric-type IDH family. (743 aa) |
| | fba | Fructose-bisphosphate aldolase, class I. (354 aa) |
| | APF18547.1 | 3-deoxy-D-arabinoheptulosonate-7-phosphate synthase. (562 aa) |
| | APF18630.1 | Phosphatidate cytidylyltransferase; Belongs to the CDS family. (275 aa) |
| | APF18636.1 | propionyl-CoA carboxylase carboxyltransferase subunit. (516 aa) |
| | trpE | Anthranilate synthase component 1; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] (494 aa) |
| | APF18648.1 | Anthranilate synthase component 2/para-aminobenzoate synthetase component 2. (195 aa) |
| | trpD | trpD anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (336 aa) |
| | trpC | trpC indole-3-glycerol phosphate synthase; Belongs to the TrpC family. (270 aa) |
| | trpF | trpF phosphoribosylanthranilate isomerase; Belongs to the TrpF family. (217 aa) |
| | trpB | trpB tryptophan synthase, beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (403 aa) |
| | trpA | trpA tryptophan synthase, alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (262 aa) |
| | APF18660.1 | 2-oxoglutarate dehydrogenase E1 component. (932 aa) |
| | APF18661.1 | 2-oxoglutarate dehydrogenase E2 component. (411 aa) |
| | gcvPA | gcvPA glycine dehydrogenase (decarboxylating) alpha subunit; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. (429 aa) |
| | gcvPB | gcvPB glycine dehydrogenase (decarboxylating) beta subunit; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. (484 aa) |
| | APF18684.1 | Aminotransferase class-III; acetylornithine/N-succinyldiaminopimelate aminotransferase/acetylornithine/LysW-gamma-L-lysine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (493 aa) |
| | APF18707.1 | Glucokinase. (304 aa) |
| | APF18717.1 | Beta-glucosidase. (749 aa) |
| | surE | surE 5'-nucleotidase /3'-nucleotidase; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (256 aa) |
| | hisA | hisA 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino) imidazole-4-carboxamide isomerase. (247 aa) |
| | hisF | hisF cyclase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (251 aa) |
| | accD | accD acetyl-CoA carboxylase carboxyl transferase subunit beta; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (283 aa) |
| | hisI | hisI phosphoribosyl-ATP pyrophosphatase; In the N-terminal section; belongs to the PRA-CH family. (197 aa) |
| | APF18771.1 | Asparagine synthase (glutamine-hydrolysing). (658 aa) |
| | APF18800.1 | Aldehyde dehydrogenase (NAD+); Belongs to the aldehyde dehydrogenase family. (513 aa) |
| | APF18805.1 | Alcohol dehydrogenase, propanol-preferring. (342 aa) |
| | plsY | plsY acyl-phosphate glycerol-3-phosphate acyltransferase; Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP. (211 aa) |
| | gpsA | gpsA glycerol 3-phosphate dehydrogenase (NAD(P)+); Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. (335 aa) |
| | APF18848.1 | Alpha-amylase. (779 aa) |
| | APF18850.1 | Beta-glucosidase; Belongs to the glycosyl hydrolase 3 family. (836 aa) |
| | APF18869.1 | N-acetylornithine carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. (325 aa) |
| | APF18870.1 | Threonine synthase. (425 aa) |
| | APF18871.1 | Cysteine synthase. (490 aa) |
| | gcvH | gcvH glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (125 aa) |
| | APF18882.1 | acetyl-CoA carboxylase, biotin carboxylase subunit; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (452 aa) |
| | APF18886.1 | Biotin carboxyl carrier protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (170 aa) |
| | miaA | miaA tRNA dimethylallyltransferase; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A); Belongs to the IPP transferase family. (305 aa) |
| | ndk | Ndk nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (138 aa) |
| | Cabys_22 | Citrate synthase; Belongs to the citrate synthase family. (435 aa) |
| | APF18996.1 | Ribose 5-phosphate isomerase B. (209 aa) |
| | APF19022.1 | Fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. (358 aa) |
| | Cabys_23 | Glycosidase. (616 aa) |
| | APF19079.1 | dTDP-glucose 4,6-dehydratase; Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily. (337 aa) |
| | APF19085.1 | aromatic-L-amino-acid decarboxylase. (474 aa) |
| | APF19096.1 | Uroporphyrinogen decarboxylase (URO-D); Belongs to the uroporphyrinogen decarboxylase family. (336 aa) |
| | hisH | hisH glutamine amidotransferase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (194 aa) |
| | hisB | Imidazoleglycerol-phosphate dehydratase; In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family. (363 aa) |
| | hisC-2 | hisC histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (356 aa) |
| | hisD | hisD histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (442 aa) |
| | hisG | hisG ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (284 aa) |
| | APF19132.1 | L-threonine aldolase. (347 aa) |
| | APF19136.1 | acetyl-CoA C-acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (365 aa) |
| | APF19138.1 | hydroxymethylglutaryl-CoA synthase. (354 aa) |
| | APF19145.1 | Undecaprenyl diphosphate synthase; Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids. (251 aa) |
| | argD | argD acetylornithine aminotransferase/acetylornithine/N-succinyldiaminopimelate aminotransferase. (393 aa) |
| | fbp | Fbp D-fructose 1,6-bisphosphatase; Belongs to the FBPase class 1 family. (338 aa) |
| | gcvT | gcvT aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. (358 aa) |
| | plsY-2 | Glycerol-3-phosphate acyltransferase PlsY; Belongs to the PlsY family. (203 aa) |
| | APF19238.1 | Riboflavin kinase / FMN adenylyltransferase; Belongs to the ribF family. (289 aa) |
| | glgA | glgA glycogen synthase (ADP-glucose); Synthesizes alpha-1,4-glucan chains using ADP-glucose. (488 aa) |
| | APF19334.1 | Phosphoenolpyruvate carboxykinase (ATP). (613 aa) |
| | APF19335.1 | Aspartate/methionine/tyrosine aminotransferase. (782 aa) |
| | APF19339.1 | Glycerol-3-phosphate dehydrogenase. (522 aa) |
| | Cabys_262 | Pyruvate-ferredoxin/flavodoxin oxidoreductase. (1192 aa) |
| | APF19380.1 | Homoaconitate hydratase family protein/3-isopropylmalate dehydratase, large subunit/3-isopropylmalate dehydratase, small subunit. (607 aa) |
| | APF19382.1 | 3-isopropylmalate dehydrogenase. (395 aa) |
| | APF19414.1 | Glucokinase. (319 aa) |
| | pckA | pckA phosphoenolpyruvate carboxykinase (ATP); Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. (534 aa) |
| | hemL | hemL glutamate-1-semialdehyde 2,1-aminomutase. (427 aa) |
| | APF19419.1 | Porphobilinogen synthase; Belongs to the ALAD family. (325 aa) |
| | APF19420.1 | Oxygen-dependent protoporphyrinogen oxidase; Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX. (453 aa) |
| | hemH | hemH ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. (335 aa) |
| | APF19422.1 | Oxygen-independent coproporphyrinogen-3 oxidase; Belongs to the anaerobic coproporphyrinogen-III oxidase family. (464 aa) |
| | hemE | hemE uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. (350 aa) |
| | hemC | hemC hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. (313 aa) |
| | hemA | hemA glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (429 aa) |
| | APF19450.1 | Anthranilate phosphoribosyltransferase/anthranilate synthase component 2. (197 aa) |
| | tpiA | tpiA triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (255 aa) |
| | pgk | Pgk phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (398 aa) |
| | APF19491.1 | Glyceraldehyde-3-phosphate dehydrogenase (NAD+); Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (333 aa) |
| | aroE | aroE shikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (279 aa) |
| | APF19520.1 | 3-phosphoshikimate 1-carboxyvinyltransferase. (420 aa) |
| | APF19535.1 | Ribulose-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (223 aa) |
| | APF19544.1 | Chorismate mutase. (101 aa) |
| | APF19553.1 | Aldose 1-epimerase; Converts alpha-aldose to the beta-anomer. (384 aa) |
| | APF19589.1 | Prephenate dehydrogenase. (348 aa) |
| | APF19590.1 | 3-deoxy-D-arabinoheptulosonate-7-phosphate synthase. (344 aa) |
| | APF19601.1 | butyryl-CoA dehydrogenase/short/branched chain acyl-CoA dehydrogenase. (385 aa) |
| | eno | Eno enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (427 aa) |
| | APF19635.1 | L-asparaginase. (329 aa) |
| | Cabys_291 | 3-ketoacyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (429 aa) |
| | APF19667.1 | D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (307 aa) |
| | Cabys_292 | Short chain enoyl-CoA hydratase; Belongs to the enoyl-CoA hydratase/isomerase family. (669 aa) |
| | APF19677.1 | Cystathionine beta-synthase. (317 aa) |
| | APF19683.1 | 4-hydroxybenzoate polyprenyltransferase. (304 aa) |
| | APF19687.1 | Lipid kinase, YegS/Rv2252/BmrU family. (289 aa) |
| | APF19691.1 | 3-oxoacyl-(acyl-carrier-protein) reductase; Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis. Belongs to the short-chain dehydrogenases/reductases (SDR) family. (247 aa) |
| | APF19718.1 | Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. (305 aa) |
| | APF19762.1 | acetyl-CoA C-acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (395 aa) |
| | acsA | acsA acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (633 aa) |
| | APF19815.1 | Saccharopine dehydrogenase, NADP-dependent. (372 aa) |
| | APF19826.1 | Glycogen operon protein; Belongs to the glycosyl hydrolase 13 family. (706 aa) |
| | APF19850.1 | Cytochrome c oxidase assembly protein subunit 15. (308 aa) |
| | ctaB | ctaB protoheme IX farnesyltransferase; Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group. (287 aa) |
| | APF19893.1 | STE24 endopeptidase. (377 aa) |
| | argC-2 | argC N-acetyl-gamma-glutamyl-phosphate reductase; Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (348 aa) |
| | APF19899.1 | acetylglutamate/LysW-gamma-L-alpha-aminoadipate kinase. (263 aa) |
| | argD-2 | argD acetylornithine aminotransferase apoenzyme. (389 aa) |
| | purF | purF amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (477 aa) |
| | purN | purN formyltetrahydrofolate-dependent phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (198 aa) |
| | purD | purD phosphoribosylamine--glycine ligase; Belongs to the GARS family. (415 aa) |
| | APF19919.1 | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (461 aa) |
| | purC | purC phosphoribosylaminoimidazole-succinocarboxamide synthase; Belongs to the SAICAR synthetase family. (461 aa) |
| | purH | purH IMP cyclohydrolase / phosphoribosylaminoimidazolecarboxamide formyltransferase. (537 aa) |
| | APF19923.1 | Phosphoribosylformylglycinamidine synthase. (272 aa) |
| | purL | purL phosphoribosylformylglycinamidine synthase subunit II; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thoug [...] (997 aa) |
| | APF19926.1 | Phosphoribosylformylglycinamidine cyclo-ligase. (380 aa) |
| | mqnD | mqnD 1,4-dihydroxy-6-naphthoate synthase; Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2); Belongs to the MqnA/MqnD family. MqnD subfamily. (261 aa) |
| | APF19928.1 | IMP dehydrogenase. (498 aa) |
| | APF19945.1 | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (536 aa) |
| | APF19946.1 | 3-isopropylmalate/(R)-2-methylmalate dehydratase small subunit; Belongs to the LeuD family. (217 aa) |
| | APF19947.1 | 3-isopropylmalate dehydratase, large subunit; Belongs to the aconitase/IPM isomerase family. (432 aa) |
| | leuA | leuA 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (521 aa) |
| | leuB | leuB 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (365 aa) |
| | ilvC | ilvC ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (331 aa) |
| | APF19951.1 | Acetolactate synthase, small subunit. (170 aa) |
| | APF19952.1 | Acetolactate synthase, large subunit. (572 aa) |
| | ilvD | ilvD dihydroxyacid dehydratase; Belongs to the IlvD/Edd family. (561 aa) |
| | APF19960.1 | Phosphomannomutase. (449 aa) |
| | APF20003.1 | Homoserine dehydrogenase. (342 aa) |
| | APF20013.1 | Homoserine dehydrogenase. (348 aa) |
| | serC | serC phosphoserine aminotransferase apoenzyme; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (361 aa) |
| | APF20027.1 | Phosphomannomutase / phosphoglucomutase. (454 aa) |
| | menG | menG demethylmenaquinone methyltransferase / 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase; Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2). (244 aa) |
| | ubiX | 4-hydroxy-3-polyprenylbenzoate decarboxylase; Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN; Belongs to the UbiX/PAD1 family. (201 aa) |
| | APF20030.1 | 4-hydroxybenzoate polyprenyltransferase; Belongs to the UbiA prenyltransferase family. (290 aa) |
| | APF20031.1 | Cytosine/adenosine deaminase. (397 aa) |
| | mqnC | mqnC de-hypoxanthine futalosine cyclase; Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2). (355 aa) |
| | mqnA | mqnA chorismate dehydratase; Catalyzes the dehydration of chorismate into 3-[(1- carboxyvinyl)oxy]benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2). (289 aa) |
| | mqnE | mqnE aminodeoxyfutalosine synthase; Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3-[(1-carboxyvinyl)oxy]benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate. (367 aa) |
| | APF20063.1 | Aspartate kinase; Belongs to the aspartokinase family. (467 aa) |
| | thrB | thrB homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (319 aa) |
| | APF20065.1 | L-threonine synthase. (433 aa) |
| | argD-3 | argD ornithine--oxo-acid transaminase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (401 aa) |
| | APF20093.1 | Farnesyl-diphosphate farnesyltransferase. (345 aa) |
| | APF20111.1 | Glucose-1-phosphate thymidylyltransferase. (354 aa) |
| | APF20141.1 | Glutamine amidotransferase class-II:Asparagine synthase. (573 aa) |
| | APF20151.1 | Asparagine synthase (glutamine-hydrolysing). (604 aa) |
| | APF20160.1 | 3-oxoacyl-(acyl-carrier protein) reductase. (242 aa) |
| | APF20162.1 | Acyl carrier protein. (78 aa) |
| | acpP-2 | acpP acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. (80 aa) |
| | APF20203.1 | 3-oxoacyl-(acyl-carrier-protein) reductase; Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis. Belongs to the short-chain dehydrogenases/reductases (SDR) family. (245 aa) |
| | APF20204.1 | (Acyl-carrier-protein) S-malonyltransferase. (308 aa) |
| | plsX | plsX phosphate:acyl-(acyl carrier protein) acyltransferase; Catalyzes the reversible formation of acyl-phosphate (acyl- PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA. (337 aa) |
| | ndk-2 | Ndk nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (144 aa) |
| | sucD | succinyl-CoA synthetase (ADP-forming) alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (293 aa) |
| | sucC | sucC succinyl-CoA synthetase (ADP-forming) beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (386 aa) |
| | APF20231.1 | Glucokinase. (372 aa) |
| | Cabys_35 | Glycosidase. (441 aa) |
| | APF20253.1 | 2-oxoglutarate dehydrogenase E2 component (dihydrolipoamide succinyltransferase). (430 aa) |
| | APF20254.1 | 2-oxoisovalerate dehydrogenase E1 component. (678 aa) |
| | APF20305.1 | Maltodextrin phosphorylase. (847 aa) |
| | Cabys_370 | Glucose-1-phosphate adenylyltransferase. (424 aa) |
| | APF20454.1 | dTDP-4-dehydrorhamnose reductase; Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose. (297 aa) |
| | accA | accA acetyl-CoA carboxylase carboxyltransferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (322 aa) |
| | APF20464.1 | dTDP-4-dehydrorhamnose reductase; Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose. (289 aa) |
| | APF20487.1 | Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (183 aa) |
| | aroQ | aroQ 3-dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (142 aa) |
| | aroB | aroB 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (362 aa) |
| | aroK | aroK shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (186 aa) |
| | sat | Sat sulfate adenylyltransferase; Belongs to the sulfate adenylyltransferase family. (378 aa) |
| | aroC | aroC chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (387 aa) |
| | APF20528.1 | Isocitrate dehydrogenase (NAD+). (341 aa) |
| | APF20544.1 | Dihydrolipoamide dehydrogenase. (475 aa) |
| | APF20545.1 | Pyruvate dehydrogenase E2 component (dihydrolipoamide acetyltransferase). (442 aa) |
| | APF20546.1 | Pyruvate dehydrogenase E1 component; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (890 aa) |
| | APF20586.1 | Isopentenyl-diphosphate delta-isomerase. (189 aa) |
| | APF20587.1 | 3-hydroxy-3-methylglutaryl-coenzyme A reductase; Belongs to the HMG-CoA reductase family. (760 aa) |
| | APF20588.1 | Phosphomevalonate kinase. (354 aa) |
| | APF20589.1 | Diphosphomevalonate decarboxylase. (328 aa) |
| | mdh | Mdh malate dehydrogenase (NAD); Catalyzes the reversible oxidation of malate to oxaloacetate. (318 aa) |
| | APF20621.1 | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. (365 aa) |
| | APF20622.1 | Riboflavin synthase alpha chain. (215 aa) |
| | ribBA | ribBA GTP cyclohydrolase II; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family. (408 aa) |
| | ribH | ribH 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. (153 aa) |
| | APF20636.1 | Bifunctional phosphoglucose/phosphomannose isomerase. (346 aa) |
| | metK | metK methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (378 aa) |
| | APF20656.1 | Homoserine dehydrogenase. (436 aa) |
| | APF20663.1 | 2',3'-cyclic-nucleotide 2'-phosphodiesterase/5'- or 3'-nucleotidase, 5'-nucleotidase family; Belongs to the 5'-nucleotidase family. (534 aa) |
| | APF20692.1 | Alpha-aminoadipic semialdehyde synthase. (378 aa) |
| | APF20698.1 | Myo-inositol-1-phosphate synthase. (441 aa) |
| | trpB-2 | trpB tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (454 aa) |
| | APF20753.1 | Ribose-phosphate pyrophosphokinase; Belongs to the ribose-phosphate pyrophosphokinase family. (348 aa) |
| | APF20754.1 | Myo-inositol-1(or 4)-monophosphatase. (265 aa) |
| | APF20818.1 | Succinate dehydrogenase subunit C. (231 aa) |
| | APF20819.1 | Succinate dehydrogenase subunit A. (636 aa) |
| | APF20820.1 | Succinate dehydrogenase / fumarate reductase iron-sulfur subunit. (251 aa) |
| | katG | katG catalase-peroxidase; Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity; Belongs to the peroxidase family. Peroxidase/catalase subfamily. (730 aa) |
| | APF20921.1 | Gluconolactonase. (302 aa) |
| | APF20945.1 | Octaprenyl-diphosphate synthase; Belongs to the FPP/GGPP synthase family. (324 aa) |
| | glyA | glyA serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (430 aa) |
| | APF20949.1 | Ribose-5-phosphate isomerase. (146 aa) |
| | glgA-2 | glgA glycogen synthase (ADP-glucose); Synthesizes alpha-1,4-glucan chains using ADP-glucose. (495 aa) |
| | panB | panB ketopantoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (271 aa) |
| | panC | panC pantothenate synthetase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (284 aa) |
| | Cabys_483 | glutaryl-CoA dehydrogenase. (387 aa) |
| | Cabys_535 | Geranylgeranyl diphosphate synthase, type I/geranylgeranyl diphosphate synthase, type II; Belongs to the FPP/GGPP synthase family. (317 aa) |
| | Cabys_548 | 4-hydroxy-3-polyprenylbenzoate decarboxylase; Belongs to the UbiD family. (607 aa) |
| | Cabys_569 | Alcohol dehydrogenase. (381 aa) |
| | Cabys_573 | 3-oxoacyl-(acyl-carrier protein) reductase. (261 aa) |
| | Cabys_582 | Homoaconitase. (657 aa) |
| | Cabys_590 | L-proline dehydrogenase. (302 aa) |
| | Cabys_599 | Methyltransferase domain-containing protein. (266 aa) |
| | Cabys_637 | Histidinol-phosphate phosphatase; Belongs to the PHP hydrolase family. HisK subfamily. (255 aa) |
| | Cabys_646 | Alpha-glucosidase. (676 aa) |
| | adk | Adk Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (219 aa) |
| | Cabys_656 | Branched-chain amino acid aminotransferase. (343 aa) |
| | gltX-2 | gltX glutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. (484 aa) |
| | Cabys_684 | Undecaprenyl diphosphate synthase; Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids. (255 aa) |
| | Cabys_704 | Malate dehydrogenase (NAD); Catalyzes the conversion of lactate to pyruvate. (316 aa) |
| | Cabys_719 | 1-acyl-sn-glycerol-3-phosphate acyltransferase; Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. (237 aa) |
| | Cabys_724 | Glyoxylate reductase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (323 aa) |
| | Cabys_734 | 3-oxoacyl-(acyl-carrier protein) reductase. (251 aa) |
| | plsX-2 | plsX phosphate:acyl-(acyl carrier protein) acyltransferase; Catalyzes the reversible formation of acyl-phosphate (acyl- PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA. (349 aa) |
| | lysA | lysA diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (418 aa) |
| | Cabys_78 | Dihydrolipoamide dehydrogenase. (463 aa) |
| | Cabys_788 | Membrane bound protein complex subunit mbxN. (596 aa) |
| | gpmI | gpmI phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (512 aa) |
| | Cabys_801 | Sulfide dehydrogenase (flavoprotein) subunit SudA. (475 aa) |
| | Cabys_82 | Aconitase. (755 aa) |
| | dapF | dapF diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (273 aa) |
| | Cabys_827 | Mannose-1-phosphate guanylyltransferase. (358 aa) |
| | pgi | Pgi glucose-6-phosphate isomerase; Belongs to the GPI family. (459 aa) |
| | Cabys_989 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1240 aa) |
| | Cabys_990 | acetyl-CoA carboxylase, biotin carboxylase subunit; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (499 aa) |
