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| | DVU_3091 | Conserved hypothetical protein; Identified by similarity to SP:Q9A4C3. (448 aa) |
| | DVU_3079 | Identified by match to protein family HMM PF00903. (200 aa) |
| | DVU_3031 | Conserved hypothetical protein; Identified by similarity to OMNI:NTL01HS00726. (363 aa) |
| | ackA | Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (402 aa) |
| | pta | Phosphate acetyltransferase; Involved in acetate metabolism; In the N-terminal section; belongs to the CobB/CobQ family. (704 aa) |
| | DVU_3013 | Glycosyl transferase, group 2 family protein; Identified by match to protein family HMM PF00535. (568 aa) |
| | DVU_3011 | Conserved hypothetical protein; Identified by similarity to OMNI:CC2858. (264 aa) |
| | moeA | Molybdopterin biosynthesis MoeA protein; Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP. Belongs to the MoeA family. (650 aa) |
| | pssA | CDP-diacylglycerol--serine O-phosphatidyltransferase; Identified by match to protein family HMM PF01066; match to protein family HMM TIGR00473; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (249 aa) |
| | psd | Phosphatidylserine decarboxylase-related protein; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). (217 aa) |
| | acsA | acetoacetyl-CoA synthase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. (661 aa) |
| | pyrE | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (186 aa) |
| | purB | Adenylosuccinate lyase; Identified by similarity to SP:P12047; match to protein family HMM PF00206; match to protein family HMM TIGR00928; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (430 aa) |
| | gpm | Phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (250 aa) |
| | lpxC | UDP-3-0-acyl N-acetylglucosamine deacetylase; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis; Belongs to the LpxC family. (308 aa) |
| | pyrC | Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate. (422 aa) |
| | pyrB | Aspartate carbamoyltransferase; Identified by similarity to SP:P05654; match to protein family HMM PF00185; match to protein family HMM PF02729; match to protein family HMM TIGR00670. (317 aa) |
| | folE2 | Conserved hypothetical protein; Converts GTP to 7,8-dihydroneopterin triphosphate. (264 aa) |
| | DVU_2838 | Conserved hypothetical protein; Identified by similarity to OMNI:NTL02ST1547. (445 aa) |
| | DVU_2804 | Identified by match to protein family HMM TIGR01409. (385 aa) |
| | DVU_2673 | Anaerobic glycerol-3-phosphate dehydrogenase, subunit A, truncation; Identified by similarity to SP:P13032; match to protein family HMM PF01266. (389 aa) |
| | glmU | UDP-N-acetylglucosamine pyrophosphorylase, putative; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. In the C-terminal section; belongs to the transferase hexapeptide repeat family. (455 aa) |
| | tkt | Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (664 aa) |
| | pgk | Phosphoglycerate kinase; Identified by match to protein family HMM PF00162; Belongs to the phosphoglycerate kinase family. (393 aa) |
| | DVU_2517 | Conserved hypothetical protein; Identified by similarity to OMNI:NTL01HP00646. (413 aa) |
| | pyk | Pyruvate kinase; Identified by match to protein family HMM PF00224; match to protein family HMM PF02887; match to protein family HMM TIGR01064; Belongs to the pyruvate kinase family. (469 aa) |
| | fdnG-2 | Formate dehydrogenase, alpha subunit, selenocysteine-containing; Selenoprotein; identified by similarity to SP:P24183; match to protein family HMM PF00384; match to protein family HMM PF01568; match to protein family HMM PF04879; match to protein family HMM TIGR01409; match to protein family HMM TIGR01553; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (1003 aa) |
| | DVU_2475 | Oxidoreductase, NAD-binding, putative; Identified by match to protein family HMM PF00175. (280 aa) |
| | lpxK | Tetraacyldisaccharide 4'-kinase; Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). (354 aa) |
| | DVU_2436 | Conserved hypothetical protein; Identified by similarity to OMNI:AF1432. (210 aa) |
| | DVU_2399 | Hydrogenase, putative; Identified by similarity to GP:21327886; match to protein family HMM PF00175; match to protein family HMM PF00970. (283 aa) |
| | lpxD | UDP-3-O-(R-3-hydroxymyristoyl)-glucosamine N-acyltransferase; Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3- hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Belongs to the transferase hexapeptide repeat family. LpxD subfamily. (344 aa) |
| | fabZ | Beta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabZ; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. (154 aa) |
| | lpxA | acyl-(acyl-carrier-protein)--UDP-N- acetylglucosamine O-acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (267 aa) |
| | DVU_2365 | Conserved hypothetical protein; Identified by similarity to OMNI:CC1910. (274 aa) |
| | DVU_0535 | Hmc operon protein 2; HMWC (high-molecular-weight cytochrome c precursor), ORF2, ORF3, ORF4, ORF5, ORF6 in the HMC operon form a transmembrane protein complex that allows electron flow from the periplasmic hydrogenase to the cytoplasmic enzymes that catalyze reduction of sulfates. ORF2 is a transmembrane redox protein. (370 aa) |
| | DVU_0528 | Phosphatidylglycerophosphatase; Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG). (159 aa) |
| | maF | Septum formation protein Maf; Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. (210 aa) |
| | DVU_0494 | Aminotransferase, class V; Identified by match to protein family HMM PF00266. (389 aa) |
| | purD | Phosphoribosylamine--glycine ligase; Identified by similarity to SP:P15640; match to protein family HMM PF01071; match to protein family HMM PF02842; match to protein family HMM PF02843; match to protein family HMM PF02844; match to protein family HMM TIGR00877; Belongs to the GARS family. (424 aa) |
| | purE | Phosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (166 aa) |
| | aroA-2 | Predicted phospho-2-dehydro-3-deoxyheptonate aldolase; Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7- dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids; Belongs to the DeoC/FbaB aldolase family. ADHS subfamily. (266 aa) |
| | ribF | Riboflavin biosynthesis protein RibF; Identified by similarity to SP:P08391; match to protein family HMM PF01687; match to protein family HMM TIGR00083; Belongs to the ribF family. (314 aa) |
| | cls | Cardiolipin synthetase; Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol; Belongs to the phospholipase D family. Cardiolipin synthase subfamily. (481 aa) |
| | folD | Methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (286 aa) |
| | eno | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis. (437 aa) |
| | coaX | Transcriptional activator, putative, Baf family; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis; Belongs to the type III pantothenate kinase family. (262 aa) |
| | fliI | Flagellum-specific ATP synthase FliI; Identified by similarity to SP:P23445; match to protein family HMM PF00006; match to protein family HMM TIGR01026. (437 aa) |
| | moaC | Molybdenum cofactor biosynthesis protein C; Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP); Belongs to the MoaC family. (161 aa) |
| | carB | Carbamoyl-phosphate synthase, large subunit; Identified by similarity to SP:P00968; match to protein family HMM PF00289; match to protein family HMM PF02142; match to protein family HMM PF02786; match to protein family HMM PF02787; match to protein family HMM TIGR01369. (1077 aa) |
| | purF | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (462 aa) |
| | DVU_0159 | Identified by match to protein family HMM PF03061. (173 aa) |
| | thiL | Thiamin-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (323 aa) |
| | DVU_0136 | Hypothetical protein; Identified by Glimmer2; putative. (72 aa) |
| | DVU_0068 | Conserved hypothetical protein; Identified by similarity to OMNI:NTL01PF0547. (511 aa) |
| | ispH | Hydroxymethylbutenyl pyrophosphate reductase; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. (290 aa) |
| | DVU_0702 | Cytochrome c family protein; Identified by similarity to SP:Q57142. (148 aa) |
| | purT | Phosphoribosylglycinamide formyltransferase 2; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family. (393 aa) |
| | purN | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (225 aa) |
| | acs | acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. (648 aa) |
| | DVU_0767 | Aminotransferase, class V; Identified by match to protein family HMM PF00266. (368 aa) |
| | DVU_0769 | Pyridoxal kinase, putative; Identified by similarity to SP:P40191; Belongs to the pyridoxine kinase family. (292 aa) |
| | atpC | ATP synthase, F1 epsilon subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. (134 aa) |
| | atpD | ATP synthase, F1 beta subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits; Belongs to the ATPase alpha/beta chains family. (470 aa) |
| | atpG | ATP synthase, F1 gamma subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. (291 aa) |
| | atpA | ATP synthase, F1 alpha subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. (502 aa) |
| | atpH | ATP synthase, F1 delta subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation; Belongs to the ATPase delta chain family. (183 aa) |
| | atpF | ATP synthase F0, B subunit, putative; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (176 aa) |
| | DVU_0780 | ATP synthase F0, B' subunit, putative; Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0). Belongs to the ATPase B chain family. (131 aa) |
| | purC | Phosphoribosylaminoimidazole-succinocarboxamide synthase; Identified by similarity to SP:Q59566; match to protein family HMM PF01259; match to protein family HMM TIGR00081; Belongs to the SAICAR synthetase family. (298 aa) |
| | dxr | 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. (408 aa) |
| | cdsA | Phosphatidate cytidylyltransferase; Identified by match to protein family HMM PF01148; Belongs to the CDS family. (268 aa) |
| | pyrH | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (238 aa) |
| | DVU_0889 | Phosphonopyruvate decarboxylase-related protein; Identified by match to protein family HMM PF01676. (379 aa) |
| | DVU_0896 | Lipoprotein, NLP/P60 family; Identified by match to protein family HMM PF00877. (464 aa) |
| | gmk | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. (207 aa) |
| | pyrF | Orotidine 5`-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (235 aa) |
| | atpE | ATP synthase F0, C subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (82 aa) |
| | atpB | ATP synthase F0, A subunit; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. (233 aa) |
| | DVU_0922 | Cytochrome c family protein. (185 aa) |
| | thiD | Phosphomethylpyrimidine kinase; Identified by match to protein family HMM TIGR00097. (268 aa) |
| | DVU_0951 | Molybdopterin biosynthesis MoeA protein, putative; Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP. Belongs to the MoeA family. (445 aa) |
| | DVU_0971 | Molybdenum cofactor biosynthesis protein; Identified by match to protein family HMM PF00994; match to protein family HMM TIGR00177. (168 aa) |
| | rluD/coaE | Ribosomal large subunit pseudouridine synthase D/dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (541 aa) |
| | upp | Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (208 aa) |
| | cmk | Cytidylate kinase; Identified by similarity to SP:P23863; match to protein family HMM PF02224; match to protein family HMM TIGR00017. (232 aa) |
| | DVU_1033 | Competence/damage-inducible protein CinA protein, truncation; Identified by similarity to SP:P46323; match to protein family HMM PF02464; match to protein family HMM TIGR00199; Belongs to the CinA family. (164 aa) |
| | DVU_1035 | Glucokinase, putative; Belongs to the bacterial glucokinase family. (339 aa) |
| | guaA | GMP synthase; Catalyzes the synthesis of GMP from XMP. (515 aa) |
| | guaB | Inosine-5`-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. (485 aa) |
| | DVU_1062 | Conserved hypothetical protein; Identified by similarity to OMNI:NTL01SS02998. (256 aa) |
| | gpt | Xanthine-guanine phosphoribosyltransferase; Acts on guanine, xanthine and to a lesser extent hypoxanthine; Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily. (163 aa) |
| | DVU_1180 | Hypothetical protein; Identified by Glimmer2; putative. (74 aa) |
| | MazG | MazG family protein; Identified by similarity to OMNI:VC2450; match to protein family HMM PF03819; match to protein family HMM TIGR00444. (267 aa) |
| | DVU_1202 | Identified by match to protein family HMM PF00383. (176 aa) |
| | plsX | Fatty acid/phospholipid synthesis protein PlsX; Catalyzes the reversible formation of acyl-phosphate (acyl- PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA. (345 aa) |
| | DVU_1214 | Identified by match to protein family HMM PF02366. (667 aa) |
| | DVU_1215 | Identified by match to protein family HMM PF01569. (218 aa) |
| | dacA | Conserved hypothetical protein TIGR00159; Catalyzes the condensation of 2 ATP molecules into cyclic di- AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria. (248 aa) |
| | ispG | 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. (386 aa) |
| | dxs | 1-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (641 aa) |
| | lpxB | Lipid A disaccharide synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (376 aa) |
| | purM | Phosphoribosylformylglycinamidine cyclo-ligase; Identified by similarity to SP:P08178; match to protein family HMM PF00586; match to protein family HMM PF02769; match to protein family HMM TIGR00878. (350 aa) |
| | DVU_1438 | Cobyrinic acid a,c-diamide synthase family protein; Identified by match to protein family HMM PF01656. (354 aa) |
| | thiM | Hydroxyethylthiazole kinase; Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ); Belongs to the Thz kinase family. (267 aa) |
| | thiE-2 | Thiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (219 aa) |
| | dut | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. (153 aa) |
| | ndk | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (139 aa) |
| | pgl | 6-phosphogluconolactonase; Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate. (249 aa) |
| | thyX | Thymidylate synthase ThyX; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. (245 aa) |
| | DVU_2250 | Identified by match to protein family HMM PF00501. (551 aa) |
| | pdxA | Pyridoxal phosphate biosynthetic protein PdxA; Identified by similarity to SP:P19624; match to protein family HMM PF04166; match to protein family HMM TIGR00557; Belongs to the PdxA family. (406 aa) |
| | DVU_2226 | acetyl-CoA carboxylase, biotin carboxylase, putative; Identified by match to protein family HMM PF00289; match to protein family HMM PF02786. (471 aa) |
| | DVU_0578 | Formate dehydrogenase accessory protein FdhD, putative; Identified by match to protein family HMM PF02634. (262 aa) |
| | DVU_2225 | acetyl-CoA carboxylase, carboxyl transferase, alpha/beta subunit. (751 aa) |
| | DVU_2212 | Conserved hypothetical protein; Identified by similarity to OMNI:NTL01MT00146. (120 aa) |
| | fba | Fructose-1,6-bisphosphate aldolase, class II; Identified by similarity to SP:P13243; match to protein family HMM PF01116; match to protein family HMM TIGR00167; match to protein family HMM TIGR01859. (307 aa) |
| | surE | Acid phosphatase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (250 aa) |
| | tmk | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (224 aa) |
| | ispD | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D- erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C- methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF); In the N-terminal section; belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily. (395 aa) |
| | DVU_1456 | Identified by match to protein family HMM PF01784; match to protein family HMM TIGR00486; Belongs to the GTP cyclohydrolase I type 2/NIF3 family. (336 aa) |
| | coaD | Pantetheine-phosphate adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (186 aa) |
| | purU | Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (284 aa) |
| | DVU_1550 | Identified by match to protein family HMM PF00300. (218 aa) |
| | DVU_1551 | HD domain protein; Identified by match to protein family HMM PF01966. (468 aa) |
| | DVU_1560 | Molybdopterin biosynthesis protein, putative; Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP. Belongs to the MoeA family. (339 aa) |
| | prsA | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (312 aa) |
| | ispE | 4-diphosphocytidyl-2C-methyl-D-erythritol kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. (286 aa) |
| | hpt | Hypoxanthine phosphoribosyltransferase; Identified by similarity to SP:P37472; match to protein family HMM PF00156; match to protein family HMM TIGR01203; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (176 aa) |
| | nadE | Glutamine-dependent NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. (559 aa) |
| | gpmA | Phosphoglycerate mutase, 2,3-bisphosphoglycerate-independent; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (511 aa) |
| | purQ | Phosphoribosylformylglycinamidine synthase I. (269 aa) |
| | pyrG | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (547 aa) |
| | DVU_1658 | Transaldolase, putative; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 3B subfamily. (215 aa) |
| | tpiA | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (251 aa) |
| | idi | Isopentenyl-diphosphate delta-isomerase; Identified by match to protein family HMM PF00293. (178 aa) |
| | suhB | Inositol-1-monophosphatase; Identified by similarity to SP:P22783; match to protein family HMM PF00459; Belongs to the inositol monophosphatase superfamily. (263 aa) |
| | DVU_1688 | 1-acyl-sn-glycerol-3-phosphate acyltransferase, putative; Identified by match to protein family HMM PF01553. (269 aa) |
| | nadC | Nicotinate-nucleotide pyrophosphorylase; Identified by match to protein family HMM PF01729; match to protein family HMM PF02749; match to protein family HMM TIGR00078; Belongs to the NadC/ModD family. (295 aa) |
| | nadA | Quinolinate synthetase complex, subunit A; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (358 aa) |
| | nadB | L-aspartate oxidase; Catalyzes the oxidation of L-aspartate to iminoaspartate. (528 aa) |
| | DVU_2131 | Hypothetical protein; Identified by Glimmer2; putative. (159 aa) |
| | thiS | Thiamine biosynthesis protein ThiS; Identified by match to protein family HMM PF02597; match to protein family HMM TIGR01683. (66 aa) |
| | thiG | thiG protein; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S; Belongs to the ThiG family. (265 aa) |
| | DVU_2092 | Identified by match to protein family HMM PF00899. (213 aa) |
| | thiE-1 | Thiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). (226 aa) |
| | relA | GTP pyrophosphokinase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (717 aa) |
| | pfkA | 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Atypical ATP-dependent clade 'X' sub-subfamily. (444 aa) |
| | DVU_2052 | Glycosyl transferase, group 2 family protein; Identified by match to protein family HMM PF00535. (240 aa) |
| | nadD | Nicotinate (nicotinamide) nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (234 aa) |
| | DVU_1940 | Anaerobic glycerol-3-phosphate dehydrogenase, A subunit, putative; Identified by similarity to SP:P13032; match to protein family HMM PF01266. (516 aa) |
| | adk | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (223 aa) |
| | nnrD | YjeF-related protein; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epi [...] (574 aa) |
| | gmhA | Phosphoheptose isomerase; Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate. (208 aa) |
| | nadK | ATP-NAD kinase domain protein; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (299 aa) |
| | DVU_1866 | Hypothetical protein; Identified by Glimmer2; putative. (233 aa) |
| | pgsA | CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Identified by match to protein family HMM PF01066; match to protein family HMM TIGR00560; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (185 aa) |
| | ptB | Phosphotransbutyrylase; Identified by similarity to GP:457633; match to protein family HMM PF01515. (343 aa) |
| | ldh | L-lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family. (309 aa) |
| | DVU_0589 | Molybdopterin-guanine dinucleotide biosynthesis protein B, putative; Identified by match to protein family HMM PF03205; match to protein family HMM PF04060. (246 aa) |
| | moaA | Molybdenum cofactor biosynthesis protein A; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate; Belongs to the radical SAM superfamily. MoaA family. (341 aa) |
| | mobA | Molybdopterin-guanine dinucleotide biosynthesis protein A, putative; Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor; Belongs to the MobA family. (222 aa) |
| | DVU_0643 | thiF protein, putative; Identified by similarity to SP:P30138; match to protein family HMM PF00899. (230 aa) |
| | dgkA | Diacylglycerol kinase; Recycling of diacylglycerol produced during the turnover of membrane phospholipid. (124 aa) |
| | DVU_3376 | Identified by match to protein family HMM PF00884. (524 aa) |
| | coaBC | Phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (404 aa) |
| | pyrD | Dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate. Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily. (307 aa) |
| | pyrK | Dihydroorotate dehydrogenase, electron transfer subunit; Identified by similarity to SP:P25983. (272 aa) |
| | DVU_3235 | IMP cyclohydrolase, putative; Identified by similarity to SP:P12048; match to protein family HMM PF02142. (200 aa) |
| | pgi | Glucose-6-phosphate isomerase; Identified by match to protein family HMM PF00342. (447 aa) |
| | plsY | Membrane protein, putative; Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP. (327 aa) |
| | DVU_3206 | Phosphoribosylaminoimidazolecarboxamide formyltransferase, putative; Identified by similarity to SP:P12048; match to protein family HMM PF01808. (510 aa) |
| | purA | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (426 aa) |
| | purL | Phosphoribosylformylglycinamidine synthase II; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist [...] (816 aa) |
| | gpsA | Glycerol-3-phosphate dehydrogenase (NAD(P)+); Identified by similarity to SP:P37606; match to protein family HMM PF01210; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. (330 aa) |
| | DVU_3154 | HAM1 family protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (207 aa) |
| | DVU_3147 | 6-phosphofructo-2-kinase/fructose-2, 6-biphosphatase; Identified by similarity to GP:3309583; match to protein family HMM PF00300; match to protein family HMM PF01591. (420 aa) |
| | glpK | Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate; Belongs to the FGGY kinase family. (497 aa) |
| | DVU_3132 | Glycerol-3-phosphate dehydrogenase, FAD-dependent; Identified by similarity to SP:P18158; match to protein family HMM PF01266; Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family. (546 aa) |
| | DVU_3121 | Aminotransferase, class V; Identified by match to protein family HMM PF00266. (376 aa) |
| | carA | Carbamoyl-phosphate synthase, small subunit; Identified by similarity to SP:P25993; match to protein family HMM PF00117; match to protein family HMM PF00988; match to protein family HMM TIGR01368. (375 aa) |
