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tolB tolB DVU_3033 DVU_3033 DVU_2944 DVU_2944 DVU_2896 DVU_2896 DVU_2822 DVU_2822 fdnG-3 fdnG-3 DVU_2811 DVU_2811 DVU_2809 DVU_2809 DVU_2744 DVU_2744 DVU_2662 DVU_2662 DVU_2661 DVU_2661 DVU_2615 DVU_2615 hynB-2 hynB-2 fdnG-2 fdnG-2 DVU_2481 DVU_2481 DVU_2409 DVU_2409 hdrB hdrB DVU_2384 DVU_2384 DVU_2371 DVU_2371 DVU_2336 DVU_2336 DVU_2297 DVU_2297 DVU_2084 DVU_2084 cpoB-2 cpoB-2 DVU_2021 DVU_2021 cpoB cpoB hynA-1 hynA-1 hynB-1 hynB-1 hysA hysA hysB hysB DVU_1901 DVU_1901 ppiB-2 ppiB-2 cyf cyf DVU_1813 DVU_1813 hydB hydB hydA hydA DVU_1668 DVU_1668 DVU_1611 DVU_1611 DVU_1578 DVU_1578 DVU_1537 DVU_1537 DVU_1468 DVU_1468 DVU_1413 DVU_1413 DVU_1388 DVU_1388 DVU_1287 DVU_1287 DVU_1243 DVU_1243 DVU_0978 DVU_0978 DVU_0852 DVU_0852 DVU_0810 DVU_0810 DVU_0766 DVU_0766 DVU_0752 DVU_0752 DVU_0745 DVU_0745 DVU_0738 DVU_0738 DVU_0712 DVU_0712 dctP dctP DVU_0702 DVU_0702 qrcB qrcB qrcC qrcC cbiKp cbiKp DVU_0647 DVU_0647 nrfA nrfA DVU_0588 DVU_0588 fdnG-1 fdnG-1 DVU_0583 DVU_0583 DVU_0547 DVU_0547 hmcA hmcA flgI flgI DVU_0514 DVU_0514 speA speA ppiB-1 ppiB-1 DVU_0266 DVU_0266 DVU_0263 DVU_0263 modA modA DVU_0173 DVU_0173 DVU_0172 DVU_0172 DVU_0169 DVU_0169 DVU_0095 DVU_0095 DVU_0089 DVU_0089 DVU_0034 DVU_0034 DVU_0011 DVU_0011 zraP zraP DVU_3278 DVU_3278 DVU_3276 DVU_3276 DVU_3171 DVU_3171 DVU_3162 DVU_3162 DVU_3143 DVU_3143 DVU_3041 DVU_3041
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
tolBtolB protein, putative; Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. (456 aa)
DVU_3033Iron-sulfur cluster-binding protein; Identified by match to protein family HMM PF00037; match to protein family HMM PF02754. (717 aa)
DVU_2944Identified by match to protein family HMM PF03734. (429 aa)
DVU_2896TPR domain protein; Identified by match to protein family HMM PF00515. (1076 aa)
DVU_2822TRAP transporter solute receptor DctP; Identified by similarity to SP:P37735; match to protein family HMM PF03480; match to protein family HMM TIGR00787. (336 aa)
fdnG-3Formate dehydrogenase, alpha subunit, selenocysteine-containing; Alpha chain of the formate dehydrogenase (FDH) that catalyzes the reversible two-electron oxidation of formate to carbon dioxide. The alpha subunit of formate dehydrogenase forms the active site. (1012 aa)
DVU_2811Formate dehydrogenase, beta subunit, putative; Beta chain of the formate dehydrogenase (FDH) that catalyzes the reversible two-electron oxidation of formate to carbon dioxide. The beta chain is an electron transfer unit. (219 aa)
DVU_2809Cytochrome c3; Participates in sulfate respiration coupled with phosphorylation by transferring electrons from the enzyme dehydrogenase to ferredoxin (By similarity). Gamma chain of the formate dehydrogenase (FDH) that catalyzes the reversible two-electron oxidation of formate to carbon dioxide. The gamma subunit of formate dehydrogenase forms a c-type heme. (144 aa)
DVU_2744High-affinity branched-chain amino acid ABC transporter, perisplasmic amino acid binding protein; Identified by match to protein family HMM PF01094. (385 aa)
DVU_2662Conserved hypothetical protein; Identified by similarity to SP:P54952. (254 aa)
DVU_2661Twin-arginine translocation pathway signal sequence domain protein. (521 aa)
DVU_2615Bacterial extracellular solute-binding protein, family 3; Identified by similarity to SP:P02911; match to protein family HMM PF00497. (282 aa)
hynB-2Periplasmic [NiFe] hydrogenase, small subunit, isozyme 2; Identified by match to protein family HMM PF01058; match to protein family HMM TIGR00391; match to protein family HMM TIGR01409; Belongs to the [NiFe]/[NiFeSe] hydrogenase small subunit family. (304 aa)
fdnG-2Formate dehydrogenase, alpha subunit, selenocysteine-containing; Selenoprotein; identified by similarity to SP:P24183; match to protein family HMM PF00384; match to protein family HMM PF01568; match to protein family HMM PF04879; match to protein family HMM TIGR01409; match to protein family HMM TIGR01553; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (1003 aa)
DVU_2481Formate dehydrogenase, beta subunit, putative; Identified by similarity to SP:P32175. (260 aa)
DVU_2409Bacterial extracellular solute-binding proteins, family 3; Identified by match to protein family HMM PF00497. (270 aa)
hdrBHeterodisulfide reductase, B subunit; Identified by similarity to GP:3378542; match to protein family HMM PF02754. (334 aa)
DVU_2384ABC transporter, periplasmic substrate-binding protein; Identified by match to protein family HMM PF00496. (639 aa)
DVU_2371N-acetylmuramoyl-L-alanine amidase, putative; Identified by match to protein family HMM PF01520. (543 aa)
DVU_2336Carboxyl-terminal protease; Identified by match to protein family HMM PF00595; match to protein family HMM PF03572; match to protein family HMM TIGR00225. (428 aa)
DVU_2297glycine/betaine/L-proline ABC transporter, periplasmic-binding protein; Identified by match to protein family HMM PF04069. (285 aa)
DVU_2084Oligopeptide-binding protein, putative; Identified by similarity to SP:P42061; match to protein family HMM PF00496. (565 aa)
cpoB-2TPR domain protein; Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division; Belongs to the CpoB family. (257 aa)
DVU_2021Hypothetical protein; Identified by Glimmer2; putative. (155 aa)
cpoBTPR domain protein; Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division; Belongs to the CpoB family. (312 aa)
hynA-1Periplasmic [NiFe] hydrogenase, large subunit, isozyme 1; Identified by similarity to SP:P21852; match to protein family HMM PF00374; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family. (566 aa)
hynB-1Periplasmic [NiFe] hydrogenase, small subunit, isozyme 1; Identified by similarity to SP:P21853; match to protein family HMM PF01058; match to protein family HMM TIGR00391; match to protein family HMM TIGR01409; Belongs to the [NiFe]/[NiFeSe] hydrogenase small subunit family. (317 aa)
hysAPeriplasmic [NiFeSe] hydrogenase, large subunit, selenocysteine-containing; Selenoprotein; identified by match to protein family HMM PF00374. (510 aa)
hysBPeriplasmic [NiFeSe] hydrogenase, small subunit; Identified by similarity to SP:P13063; match to protein family HMM PF01058; match to protein family HMM TIGR00391; match to protein family HMM TIGR01409. (317 aa)
DVU_1901Peptidyl-prolyl cis-trans isomerase domain protein; Identified by match to protein family HMM PF00639. (348 aa)
ppiB-2Peptidyl-prolyl cis-trans isomerase B; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (164 aa)
cyfCytochrome c-553; Natural electron acceptor for a formate dehydrogenase. (103 aa)
DVU_1813Hypothetical protein; Identified by Glimmer2; putative. (97 aa)
hydBPeriplasmic [Fe] hydrogenase, small subunit; May be involved in hydrogen uptake for the reduction of sulfate to hydrogen sulfide in an electron transport chain. Cytochrome c3 is likely to be the physiological electron carrier for the enzyme. (123 aa)
hydAPeriplasmic [Fe] hydrogenase, large subunit; May be involved in hydrogen uptake for the reduction of sulfate to hydrogen sulfide in an electron transport chain. Cytochrome c3 is likely to be the physiological electron carrier for the enzyme. (421 aa)
DVU_1668Outer membrane lipoprotein carrier protein, putative; Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane). (225 aa)
DVU_1611Molybdopterin oxidoreductase domain protein; Identified by match to protein family HMM PF00384; match to protein family HMM PF04879; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (642 aa)
DVU_1578TPR domain protein; Identified by match to protein family HMM PF01435. (481 aa)
DVU_1537Lipoprotein, putative; Identified by match to protein family HMM PF03938. (188 aa)
DVU_1468peptidase/PDZ domain protein; Identified by match to protein family HMM PF00089; match to protein family HMM PF00595; Belongs to the peptidase S1C family. (482 aa)
DVU_1413Conserved hypothetical protein; Identified by similarity to GP:3128261. (430 aa)
DVU_1388Conserved hypothetical protein; Identified by similarity to OMNI:SO1143. (251 aa)
DVU_1287Reductase, iron-sulfur binding subunit, putative; Identified by match to protein family HMM PF00037. (261 aa)
DVU_1243Conserved hypothetical protein; Identified by similarity to GP:22799047. (210 aa)
DVU_0978ABC transporter, periplasmic substrate-binding protein, putative; Identified by similarity to GP:14330288. (284 aa)
DVU_0852Extracellular solute-binding protein, putative. (265 aa)
DVU_0810Hypothetical protein; Identified by Glimmer2; putative. (686 aa)
DVU_0766Transporter, putative; Identified by match to protein family HMM PF04972. (176 aa)
DVU_0752Amino acid ABC transporter, amino acid-binding protein; Identified by match to protein family HMM PF00497. (275 aa)
DVU_0745ABC transporter, periplasmic substrate-binding protein; Identified by similarity to GP:14330288; match to protein family HMM PF01547. (272 aa)
DVU_0738Substrate-binding protein, putative; Identified by match to protein family HMM PF01094. (373 aa)
DVU_0712Amino acid ABC transporter, periplasmic-binding protein; Identified by match to protein family HMM PF01094. (376 aa)
dctPTRAP transporter solute receptor DctP; Identified by similarity to SP:P37735; match to protein family HMM PF03480; match to protein family HMM TIGR00787. (338 aa)
DVU_0702Cytochrome c family protein; Identified by similarity to SP:Q57142. (148 aa)
qrcBMolybdopterin oxidoreductase, molybdopterin-binding subunit, putative; Component of the respiratory Qrc complex, that catalyzes the reduction of the menaquinone pool using electrons transferred from the reduced periplasmic cytochrome c3, and which is probably involved in sulfate respiration. Is likely essential for growth on H(2) or formate since the periplasmic hydrogenases and/or formate dehydrogenases act as primary electron donors for the Qrc complex. The function of the QrcB subunit is unknown; in the absence of a catalytic site, it may provide a structural scaffold for the other [...] (691 aa)
qrcCMolybdopterin oxidoreductase, iron-sulfur cluster-binding subunit, putative; Component of the respiratory Qrc complex, that catalyzes the reduction of the menaquinone pool using electrons transferred from the reduced periplasmic cytochrome c3, and which is probably involved in sulfate respiration. Is likely essential for growth on H(2) or formate since the periplasmic hydrogenases and/or formate dehydrogenases act as primary electron donors for the Qrc complex. QrcC is an electron- transferring subunit; its cubane iron sulfur clusters form a pathway for electron transfer between the he [...] (255 aa)
cbiKpChelatase, putative; Catalyzes the insertion of Co(2+) into sirohydrochlorin. To a lesser extent, is also able to insert Fe(2+) into sirohydrochlorin, yielding siroheme. Its periplasmic location means that it cannot participate in cobalamin biosynthesis and its genomic environment suggests it is likely to be associated with a heme or metal transport system. (297 aa)
DVU_0647Iron compound ABC transporter, periplasmic iron compount-binding protein, putative; Identified by similarity to OMNI:DRB0007; match to protein family HMM PF01497. (304 aa)
nrfACytochrome c nitrite reductase, catalytic subunit NfrA, putative; Catalytic subunit of the cytochrome c nitrite reductase holocomplex NrfHA. Has both nitrite and sulfite reductase activities. Catalyzes the reduction of nitrite to ammonia, consuming six electrons acquired by the electron donor subunit NrfH from the menaquinone pool, in an anaerobic respiratory process of nitrite. The other biological function of the NrfHA holocomplex is to detoxify nitrite. This function is essential for the survival of this organism as it enables it to overcome inhibition by nitrite, which is produced [...] (524 aa)
DVU_0588Formate dehydrogenase, beta subunit, putative; Identified by similarity to SP:P32175. (236 aa)
fdnG-1Formate dehydrogenase, alpha subunit, selenocysteine-containing; Selenoprotein; identified by similarity to SP:P24183; match to protein family HMM PF00384; match to protein family HMM PF01568; match to protein family HMM PF04879; match to protein family HMM TIGR01409; match to protein family HMM TIGR01553. (1005 aa)
DVU_0583Lipoprotein, putative; Identified by match to protein family HMM PF01094. (423 aa)
DVU_0547Branched-chain amino acid transport system substrate-binding protein; Identified by match to protein family HMM PF01094. (372 aa)
hmcAHigh-molecular-weight cytochrome C; HMWC (high-molecular-weight cytochrome c), ORF2, ORF3, ORF4, ORF5 and ORF6 in the HMC operon form a transmembrane protein complex that allows electron flow from the periplasmic hydrogenase to the cytoplasmic enzymes that catalyze reduction of sulfates. (560 aa)
flgIFlagellar P-ring protein FlgI; Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation. (378 aa)
DVU_0514Identified by match to protein family HMM PF03240. (310 aa)
speAArginine decarboxylase; Catalyzes the biosynthesis of agmatine from arginine. Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily. (659 aa)
ppiB-1Peptidyl-prolyl cis-trans isomerase B; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (164 aa)
DVU_0266Hypothetical protein; Identified by Glimmer2; putative. (408 aa)
DVU_0263Acidic cytochrome c3; Identified by similarity to SP:P94690. (126 aa)
modAMolybdenum ABC transporter, periplasmic molybdenum-binding protein; Identified by similarity to SP:P37329; match to protein family HMM PF01547; match to protein family HMM TIGR01256. (269 aa)
DVU_0173Thiosulfate reductase, putative; Identified by similarity to SP:P37600; match to protein family HMM PF00384; match to protein family HMM PF01568; match to protein family HMM PF04879. (733 aa)
DVU_0172Iron-sulfur cluster-binding protein; Identified by match to protein family HMM PF00037. (333 aa)
DVU_0169Oligopeptide/dipeptide ABC transporter, periplasmic oligopeptide/dipeptide-binding protein; Identified by match to protein family HMM PF00496. (520 aa)
DVU_0095Polyamine ABC transporter, periplasmic polyamine-binding protein; Required for the activity of the bacterial periplasmic transport system of putrescine; Belongs to the bacterial solute-binding protein PotD/PotF family. (345 aa)
DVU_0089Conserved hypothetical protein; Identified by similarity to OMNI:VCA0583. (267 aa)
DVU_0034DSBA-like thioredoxin domain protein; Identified by match to protein family HMM PF01323. (261 aa)
DVU_0011TRAP transporter solute receptor DctP; Identified by similarity to SP:P37735; match to protein family HMM PF03480; match to protein family HMM TIGR00787. (341 aa)
zraPZinc resistance-associated protein; Identified by similarity to SP:P32682; Belongs to the ZraP family. (173 aa)
DVU_3278peptidase/PDZ domain protein; Identified by match to protein family HMM PF00089; match to protein family HMM PF00595. (518 aa)
DVU_3276Identified by similarity to SP:P08813; match to protein family HMM PF00037. (62 aa)
DVU_3171Cytochrome c3; Participates in sulfate respiration coupled with phosphorylation by transferring electrons from the enzyme dehydrogenase to ferredoxin. (129 aa)
DVU_3162ABC transporter, periplasmic substrate-binding protein; Identified by similarity to SP:P10904; match to protein family HMM PF01547. (431 aa)
DVU_3143Iron-sulfur cluster-binding protein; Identified by match to protein family HMM PF00037; match to protein family HMM TIGR01409. (529 aa)
DVU_3041Cytochrome c553; Identified by similarity to SP:P00120; match to protein family HMM PF00034. (93 aa)
Your Current Organism:
Desulfovibrio vulgaris Hildenborough
NCBI taxonomy Id: 882
Other names: D. vulgaris str. Hildenborough, Desulfovibrio vulgaris (STRAIN HILDENBOROUGH), Desulfovibrio vulgaris ATCC 29579, Desulfovibrio vulgaris str. Hildenborough, Desulfovibrio vulgaris subsp. vulgaris (strain Hildenborough), Desulfovibrio vulgaris subsp. vulgaris ATCC 29579, Desulfovibrio vulgaris subsp. vulgaris str. Hildenborough
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