STRINGSTRING
qrcD qrcD DVU_0686 DVU_0686 DVU_0588 DVU_0588 fdnG-1 fdnG-1 DVU_0534 DVU_0534 fumC fumC DVU_0163 DVU_0163 DVU_0172 DVU_0172 DVU_0173 DVU_0173 DVU_0263 DVU_0263 DVU_0367 DVU_0367 DVU_0429 DVU_0429 DVU_0430 DVU_0430 DVU_0433 DVU_0433 DVU_0434 DVU_0434 DVU_3364 DVU_3364 icd icd DVU_2811 DVU_2811 fdnG-3 fdnG-3 DVU_3028 DVU_3028 DVU_3143 DVU_3143 DVU_3145 DVU_3145 DVU_3171 DVU_3171 ubiE ubiE roO roO frdC frdC frdB frdB cydB cydB cydA cydA DVU_2809 DVU_2809 DVU_2674 DVU_2674 hynA-2 hynA-2 hynB-2 hynB-2 DVU_2485 DVU_2485 DVU_2481 DVU_2481 hdrA hdrA DVU_2291 DVU_2291 DVU_2289 DVU_2289 DVU_2287 DVU_2287 DVU_2286 DVU_2286 sucCD sucCD DVU_2012 DVU_2012 hynA-1 hynA-1 hynB-1 hynB-1 hysB hysB hysA hysA aspA aspA DVU_1815 DVU_1815 DVU_1814 DVU_1814 DVU_1783 DVU_1783 DVU_1772 DVU_1772 hydA hydA DVU_1766 DVU_1766 DVU_1611 DVU_1611 DVU_1287 DVU_1287 DVU_1286 DVU_1286 DVU_1064 DVU_1064 DVU_1019 DVU_1019 DVU_0848 DVU_0848 DVU_0826 DVU_0826 glcB glcB qrcB qrcB qrcC qrcC
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
qrcDMolybdopterin oxidoreductase, transmembrane subunit, putative; Component of the respiratory Qrc complex, that catalyzes the reduction of the menaquinone pool using electrons transferred from the reduced periplasmic cytochrome c3, and which is probably involved in sulfate respiration. Is likely essential for growth on H(2) or formate since the periplasmic hydrogenases and/or formate dehydrogenases act as primary electron donors for the Qrc complex. The QrcD subunit anchors the protein complex to the membrane and likely interacts with the quinone pool. (419 aa)
DVU_0686Iron-sulfur cluster-binding protein; Identified by match to protein family HMM PF00037. (162 aa)
DVU_0588Formate dehydrogenase, beta subunit, putative; Identified by similarity to SP:P32175. (236 aa)
fdnG-1Formate dehydrogenase, alpha subunit, selenocysteine-containing; Selenoprotein; identified by similarity to SP:P24183; match to protein family HMM PF00384; match to protein family HMM PF01568; match to protein family HMM PF04879; match to protein family HMM TIGR01409; match to protein family HMM TIGR01553. (1005 aa)
DVU_0534Hmc operon protein 3; HMWC (high-molecular-weight cytochrome c), ORF2, ORF3, ORF4, ORF5 and ORF6 in the HMC operon form a transmembrane protein complex that allows electron flow from the periplasmic hydrogenase to the cytoplasmic enzymes that catalyze reduction of sulfates; Belongs to the NrfD family. (388 aa)
fumCFumarate hydratase, class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (468 aa)
DVU_0163Lipoprotein, putative. (186 aa)
DVU_0172Iron-sulfur cluster-binding protein; Identified by match to protein family HMM PF00037. (333 aa)
DVU_0173Thiosulfate reductase, putative; Identified by similarity to SP:P37600; match to protein family HMM PF00384; match to protein family HMM PF01568; match to protein family HMM PF04879. (733 aa)
DVU_0263Acidic cytochrome c3; Identified by similarity to SP:P94690. (126 aa)
DVU_0367Identified by match to protein family HMM PF00149. (244 aa)
DVU_0429Ech hydrogenase, subunit EchF, putative; Identified by similarity to GP:3005972; match to protein family HMM PF00037. (133 aa)
DVU_0430Ech hydrogenase, subunit EchE, putative; Identified by similarity to GP:3005971; match to protein family HMM PF00346. (358 aa)
DVU_0433Ech hydrogenase, subunit EchB, putative; Identified by similarity to GP:3005968; match to protein family HMM PF00146. (282 aa)
DVU_0434Ech hydrogenase, subunit EchA, putative; Identified by similarity to GP:3005967; match to protein family HMM PF00361. (648 aa)
DVU_3364Conserved hypothetical protein; Identified by similarity to OMNI:NTL01TT1406. (307 aa)
icdIsocitrate dehydrogenase, NADP-dependent; Identified by match to protein family HMM PF00180; match to protein family HMM TIGR00183. (380 aa)
DVU_2811Formate dehydrogenase, beta subunit, putative; Beta chain of the formate dehydrogenase (FDH) that catalyzes the reversible two-electron oxidation of formate to carbon dioxide. The beta chain is an electron transfer unit. (219 aa)
fdnG-3Formate dehydrogenase, alpha subunit, selenocysteine-containing; Alpha chain of the formate dehydrogenase (FDH) that catalyzes the reversible two-electron oxidation of formate to carbon dioxide. The alpha subunit of formate dehydrogenase forms the active site. (1012 aa)
DVU_3028Iron-sulfur cluster-binding protein; Identified by match to protein family HMM PF00037; match to protein family HMM PF02754. (422 aa)
DVU_3143Iron-sulfur cluster-binding protein; Identified by match to protein family HMM PF00037; match to protein family HMM TIGR01409. (529 aa)
DVU_3145Hydrogenase, b-type cytochrome subunit, putative; Identified by match to protein family HMM PF01292. (202 aa)
DVU_3171Cytochrome c3; Participates in sulfate respiration coupled with phosphorylation by transferring electrons from the enzyme dehydrogenase to ferredoxin. (129 aa)
ubiEUbiquinone/menaquinone biosynthesis methlytransferase UbiE; Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3- methyl-6-methoxy-1,4-benzoquinol (DMQH2). (258 aa)
roORubredoxin-oxygen oxidoreductase; Identified by similarity to SP:Q9F0J6; match to protein family HMM PF00258; match to protein family HMM PF00753. (402 aa)
frdCFumarate reductase, cytochrome b subunit; Identified by similarity to SP:P17413. (216 aa)
frdBFumarate reductase, iron-sulfur protein; Identified by similarity to SP:P17596; match to protein family HMM PF00037; match to protein family HMM TIGR00384. (247 aa)
cydBCytochrome d ubiquinol oxidase, subunit II; Identified by similarity to SP:P94365; match to protein family HMM PF02322; match to protein family HMM TIGR00203. (341 aa)
cydACytochrome d ubiquinol oxidase, subunit I; Identified by similarity to SP:P94364; match to protein family HMM PF01654. (433 aa)
DVU_2809Cytochrome c3; Participates in sulfate respiration coupled with phosphorylation by transferring electrons from the enzyme dehydrogenase to ferredoxin (By similarity). Gamma chain of the formate dehydrogenase (FDH) that catalyzes the reversible two-electron oxidation of formate to carbon dioxide. The gamma subunit of formate dehydrogenase forms a c-type heme. (144 aa)
DVU_2674Succinate dehydrogenase and fumarate reductase iron-sulfur protein; Identified by match to protein family HMM PF00037; match to protein family HMM PF00111; match to protein family HMM TIGR00384; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (239 aa)
hynA-2Periplasmic [NiFe] hydrogenase, large subunit, isozyme 2; Identified by similarity to SP:P21852; match to protein family HMM PF00374; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family. (549 aa)
hynB-2Periplasmic [NiFe] hydrogenase, small subunit, isozyme 2; Identified by match to protein family HMM PF01058; match to protein family HMM TIGR00391; match to protein family HMM TIGR01409; Belongs to the [NiFe]/[NiFeSe] hydrogenase small subunit family. (304 aa)
DVU_2485Membrane protein, putative. (354 aa)
DVU_2481Formate dehydrogenase, beta subunit, putative; Identified by similarity to SP:P32175. (260 aa)
hdrAHeterodisulfide reductase, A subunit; Identified by similarity to GP:12642418; match to protein family HMM PF00037. (652 aa)
DVU_2291Carbon monoxide-induced hydrogenase CooH, putative; Identified by similarity to SP:P31895; match to protein family HMM PF00346. (366 aa)
DVU_2289Hydrogenase, CooX subunit, putative; Identified by match to protein family HMM PF00037. (211 aa)
DVU_2287Hydrogenase, CooK subunit, selenocysteine-containing, putative; Selenoprotein; identified by similarity to GP:1515467; match to protein family HMM PF00146. (321 aa)
DVU_2286Hydrogenase, CooM subunit, putative; Identified by similarity to GP:1515466; match to protein family HMM PF00361. (1253 aa)
sucCDsuccinyl-CoA synthase, beta/alpha subunits; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (709 aa)
DVU_2012Hypothetical protein; Identified by Glimmer2; putative. (61 aa)
hynA-1Periplasmic [NiFe] hydrogenase, large subunit, isozyme 1; Identified by similarity to SP:P21852; match to protein family HMM PF00374; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family. (566 aa)
hynB-1Periplasmic [NiFe] hydrogenase, small subunit, isozyme 1; Identified by similarity to SP:P21853; match to protein family HMM PF01058; match to protein family HMM TIGR00391; match to protein family HMM TIGR01409; Belongs to the [NiFe]/[NiFeSe] hydrogenase small subunit family. (317 aa)
hysBPeriplasmic [NiFeSe] hydrogenase, small subunit; Identified by similarity to SP:P13063; match to protein family HMM PF01058; match to protein family HMM TIGR00391; match to protein family HMM TIGR01409. (317 aa)
hysAPeriplasmic [NiFeSe] hydrogenase, large subunit, selenocysteine-containing; Selenoprotein; identified by match to protein family HMM PF00374. (510 aa)
aspAAspartate ammonia-lyase; Identified by similarity to SP:P07346; match to protein family HMM PF00206; match to protein family HMM TIGR00839. (468 aa)
DVU_1815Cytochrome c oxidase, subunit I, putative; Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B. (541 aa)
DVU_1814Cytochrome c oxidase, subunit III, putative; Identified by similarity to SP:P50677; match to protein family HMM PF00510. (203 aa)
DVU_1783Cysteine-rich domain protein; Identified by match to protein family HMM PF02754. (250 aa)
DVU_1772Pyridine nucleotide-disulfide oxidoreductase; Identified by match to protein family HMM PF00070. (673 aa)
hydAPeriplasmic [Fe] hydrogenase, large subunit; May be involved in hydrogen uptake for the reduction of sulfate to hydrogen sulfide in an electron transport chain. Cytochrome c3 is likely to be the physiological electron carrier for the enzyme. (421 aa)
DVU_1766Aspartate ammonia-lyase, putative; Identified by similarity to SP:P26899; match to protein family HMM PF00206. (470 aa)
DVU_1611Molybdopterin oxidoreductase domain protein; Identified by match to protein family HMM PF00384; match to protein family HMM PF04879; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (642 aa)
DVU_1287Reductase, iron-sulfur binding subunit, putative; Identified by match to protein family HMM PF00037. (261 aa)
DVU_1286Reductase, transmembrane subunit, putative; Identified by match to protein family HMM PF03916. (387 aa)
DVU_1064Aconitate hydratase, putative; Identified by match to protein family HMM PF00330; match to protein family HMM PF00694; match to protein family HMM TIGR01342. (642 aa)
DVU_1019Conserved domain protein; Identified by similarity to OMNI:VCA1081. (406 aa)
DVU_0848Heterodisulfide reductase, putative; Identified by similarity to GP:1890204. (412 aa)
DVU_0826Glycolate oxidase, iron-sulfur subunit, putative; Identified by similarity to SP:P52074; match to protein family HMM PF00037; match to protein family HMM PF02754. (440 aa)
glcBMalate synthase G; Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl- CoA) and glyoxylate to form malate and CoA; Belongs to the malate synthase family. GlcB subfamily. (729 aa)
qrcBMolybdopterin oxidoreductase, molybdopterin-binding subunit, putative; Component of the respiratory Qrc complex, that catalyzes the reduction of the menaquinone pool using electrons transferred from the reduced periplasmic cytochrome c3, and which is probably involved in sulfate respiration. Is likely essential for growth on H(2) or formate since the periplasmic hydrogenases and/or formate dehydrogenases act as primary electron donors for the Qrc complex. The function of the QrcB subunit is unknown; in the absence of a catalytic site, it may provide a structural scaffold for the other [...] (691 aa)
qrcCMolybdopterin oxidoreductase, iron-sulfur cluster-binding subunit, putative; Component of the respiratory Qrc complex, that catalyzes the reduction of the menaquinone pool using electrons transferred from the reduced periplasmic cytochrome c3, and which is probably involved in sulfate respiration. Is likely essential for growth on H(2) or formate since the periplasmic hydrogenases and/or formate dehydrogenases act as primary electron donors for the Qrc complex. QrcC is an electron- transferring subunit; its cubane iron sulfur clusters form a pathway for electron transfer between the he [...] (255 aa)
Your Current Organism:
Desulfovibrio vulgaris Hildenborough
NCBI taxonomy Id: 882
Other names: D. vulgaris str. Hildenborough, Desulfovibrio vulgaris (STRAIN HILDENBOROUGH), Desulfovibrio vulgaris ATCC 29579, Desulfovibrio vulgaris str. Hildenborough, Desulfovibrio vulgaris subsp. vulgaris (strain Hildenborough), Desulfovibrio vulgaris subsp. vulgaris ATCC 29579, Desulfovibrio vulgaris subsp. vulgaris str. Hildenborough
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.