STRINGSTRING
bioB bioB ispH ispH DVU_0135 DVU_0135 purF purF DVU_0173 DVU_0173 dsvA dsvA dvsB dvsB DVU_0432 DVU_0432 DVU_0531 DVU_0531 DVU_0535 DVU_0535 moaA moaA fdnG-1 fdnG-1 DVU_0589 DVU_0589 qrcC qrcC qrcB qrcB DVU_0855 DVU_0855 DVU_0857 DVU_0857 lipA lipA rumA rumA miaB miaB nth nth ispG ispG thiC thiC DVU_1554 DVU_1554 DVU_1597 DVU_1597 ThiH ThiH DVU_1767 DVU_1767 hydA hydA nadA nadA DVU_1823 DVU_1823 hysB hysB hysA hysA hynB-1 hynB-1 DVU_1951 DVU_1951 hcp hcp cooS cooS DVU_2413 DVU_2413 fdnG-2 fdnG-2 hynB-2 hynB-2 hcp-2 hcp-2 queE queE DVU_2674 DVU_2674 mqnE mqnE mqnC mqnC rnfB rnfB DVU_2811 DVU_2811 fdnG-3 fdnG-3 rlmN rlmN leuC leuC DVU_3004 DVU_3004 poR poR queH queH DVU_3057 DVU_3057 rimO rimO DVU_3241 DVU_3241 DVU_3291 DVU_3291 ilvD ilvD
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
bioBBiotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (310 aa)
ispHHydroxymethylbutenyl pyrophosphate reductase; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. (290 aa)
DVU_0135Conserved hypothetical protein; Identified by similarity to OMNI:NTL01AA00924; Belongs to the TtcA family. (303 aa)
purFAmidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (462 aa)
DVU_0173Thiosulfate reductase, putative; Identified by similarity to SP:P37600; match to protein family HMM PF00384; match to protein family HMM PF01568; match to protein family HMM PF04879. (733 aa)
dsvADissimilatory sulfite reductase alpha subunit; Part of the complex that catalyzes the reduction of sulfite to sulfide. The alpha and beta subunits may have arisen by gene duplication. They both bind 2 iron-sulfur clusters, but the alpha subunit seems to be catalytically inactive, due to substitutions along the putative substrate access channel, and because it binds sirohydrochlorin (the dematallated form of siroheme) instead of siroheme. (437 aa)
dvsBDissimilatory sulfite reductase beta subunit; Catalyzes the reduction of sulfite to sulfide. This is the terminal oxidation reaction in sulfate respiration, a process catalyzed by the sulfate-reducing bacteria. (381 aa)
DVU_0432Ech hydrogenase, subunit EchC, putative; Identified by similarity to GP:3005969; Belongs to the complex I 20 kDa subunit family. (157 aa)
DVU_0531Hmc operon protein 6; HMWC (high-molecular-weight cytochrome c precursor), ORF2, ORF3, ORF4, ORF5, ORF6 in the HMC operon form a transmembrane protein complex that allows electron flow from the periplasmic hydrogenase to the cytoplasmic enzymes that catalyze reduction of sulfates. ORF6 is a redox protein. (461 aa)
DVU_0535Hmc operon protein 2; HMWC (high-molecular-weight cytochrome c precursor), ORF2, ORF3, ORF4, ORF5, ORF6 in the HMC operon form a transmembrane protein complex that allows electron flow from the periplasmic hydrogenase to the cytoplasmic enzymes that catalyze reduction of sulfates. ORF2 is a transmembrane redox protein. (370 aa)
moaAMolybdenum cofactor biosynthesis protein A; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate; Belongs to the radical SAM superfamily. MoaA family. (341 aa)
fdnG-1Formate dehydrogenase, alpha subunit, selenocysteine-containing; Selenoprotein; identified by similarity to SP:P24183; match to protein family HMM PF00384; match to protein family HMM PF01568; match to protein family HMM PF04879; match to protein family HMM TIGR01409; match to protein family HMM TIGR01553. (1005 aa)
DVU_0589Molybdopterin-guanine dinucleotide biosynthesis protein B, putative; Identified by match to protein family HMM PF03205; match to protein family HMM PF04060. (246 aa)
qrcCMolybdopterin oxidoreductase, iron-sulfur cluster-binding subunit, putative; Component of the respiratory Qrc complex, that catalyzes the reduction of the menaquinone pool using electrons transferred from the reduced periplasmic cytochrome c3, and which is probably involved in sulfate respiration. Is likely essential for growth on H(2) or formate since the periplasmic hydrogenases and/or formate dehydrogenases act as primary electron donors for the Qrc complex. QrcC is an electron- transferring subunit; its cubane iron sulfur clusters form a pathway for electron transfer between the he [...] (255 aa)
qrcBMolybdopterin oxidoreductase, molybdopterin-binding subunit, putative; Component of the respiratory Qrc complex, that catalyzes the reduction of the menaquinone pool using electrons transferred from the reduced periplasmic cytochrome c3, and which is probably involved in sulfate respiration. Is likely essential for growth on H(2) or formate since the periplasmic hydrogenases and/or formate dehydrogenases act as primary electron donors for the Qrc complex. The function of the QrcB subunit is unknown; in the absence of a catalytic site, it may provide a structural scaffold for the other [...] (691 aa)
DVU_0855Radical SAM domain protein; Identified by match to protein family HMM PF04055. (367 aa)
DVU_0857Radical SAM domain protein; Identified by match to protein family HMM PF04055. (393 aa)
lipALipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (298 aa)
rumA23S rRNA (uracil-5-)-methyltransferase RumA; Identified by match to protein family HMM PF01938; match to protein family HMM PF05958; match to protein family HMM TIGR00479; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. (468 aa)
miaBtRNA-i(6)A37 modification enzyme MiaB; Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6- (dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine. (449 aa)
nthEndonuclease III, putative; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (285 aa)
ispG1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. (386 aa)
thiCThiamine biosynthesis protein ThiC; Identified by match to protein family HMM PF01964; match to protein family HMM TIGR00190. (429 aa)
DVU_1554Radical SAM domain protein; Identified by match to protein family HMM PF04055. (543 aa)
DVU_1597Sulfite reductase, assimilatory-type; This enzyme catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. (218 aa)
ThiHthiH protein, putative; Identified by similarity to SP:P30140; match to protein family HMM PF04055. (464 aa)
DVU_1767Radical SAM domain protein; Identified by match to protein family HMM PF04055. (322 aa)
hydAPeriplasmic [Fe] hydrogenase, large subunit; May be involved in hydrogen uptake for the reduction of sulfate to hydrogen sulfide in an electron transport chain. Cytochrome c3 is likely to be the physiological electron carrier for the enzyme. (421 aa)
nadAQuinolinate synthetase complex, subunit A; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (358 aa)
DVU_1823Glutamate synthase, iron-sulfur cluster-binding subunit, putative; Identified by match to protein family HMM PF00037; match to protein family HMM PF01645. (507 aa)
hysBPeriplasmic [NiFeSe] hydrogenase, small subunit; Identified by similarity to SP:P13063; match to protein family HMM PF01058; match to protein family HMM TIGR00391; match to protein family HMM TIGR01409. (317 aa)
hysAPeriplasmic [NiFeSe] hydrogenase, large subunit, selenocysteine-containing; Selenoprotein; identified by match to protein family HMM PF00374. (510 aa)
hynB-1Periplasmic [NiFe] hydrogenase, small subunit, isozyme 1; Identified by similarity to SP:P21853; match to protein family HMM PF01058; match to protein family HMM TIGR00391; match to protein family HMM TIGR01409; Belongs to the [NiFe]/[NiFeSe] hydrogenase small subunit family. (317 aa)
DVU_1951Indolepyruvate ferredoxin oxidoreductase, alpha subunit, putative; Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates. (616 aa)
hcpHybrid cluster protein; Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O; Belongs to the HCP family. (553 aa)
cooSCarbon monoxide dehydrogenase; Identified by similarity to SP:P31896. (629 aa)
DVU_2413Radical SAM domain protein; Identified by match to protein family HMM PF04055. (680 aa)
fdnG-2Formate dehydrogenase, alpha subunit, selenocysteine-containing; Selenoprotein; identified by similarity to SP:P24183; match to protein family HMM PF00384; match to protein family HMM PF01568; match to protein family HMM PF04879; match to protein family HMM TIGR01409; match to protein family HMM TIGR01553; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (1003 aa)
hynB-2Periplasmic [NiFe] hydrogenase, small subunit, isozyme 2; Identified by match to protein family HMM PF01058; match to protein family HMM TIGR00391; match to protein family HMM TIGR01409; Belongs to the [NiFe]/[NiFeSe] hydrogenase small subunit family. (304 aa)
hcp-2Hybrid cluster protein; Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O. (539 aa)
queEConserved hypothetical protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. (216 aa)
DVU_2674Succinate dehydrogenase and fumarate reductase iron-sulfur protein; Identified by match to protein family HMM PF00037; match to protein family HMM PF00111; match to protein family HMM TIGR00384; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (239 aa)
mqnERadical SAM domain protein; Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3-[(1-carboxyvinyl)oxy]benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate. (372 aa)
mqnCRadical SAM domain protein; Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2). (375 aa)
rnfBIron-sulfur cluster-binding protein; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfB subfamily. (295 aa)
DVU_2811Formate dehydrogenase, beta subunit, putative; Beta chain of the formate dehydrogenase (FDH) that catalyzes the reversible two-electron oxidation of formate to carbon dioxide. The beta chain is an electron transfer unit. (219 aa)
fdnG-3Formate dehydrogenase, alpha subunit, selenocysteine-containing; Alpha chain of the formate dehydrogenase (FDH) that catalyzes the reversible two-electron oxidation of formate to carbon dioxide. The alpha subunit of formate dehydrogenase forms the active site. (1012 aa)
rlmNRadical SAM enzyme, Cfr family; Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity; Belongs to the radical SAM superfamily. RlmN family. (364 aa)
leuC3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily. (419 aa)
DVU_3004Radical SAM domain protein; Identified by match to protein family HMM PF04055. (624 aa)
poRPyruvate-ferredoxin oxidoreductase; Identified by similarity to GP:1770208; match to protein family HMM PF00037; match to protein family HMM PF01558; match to protein family HMM PF01855. (1215 aa)
queHConserved hypothetical protein; Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr). (217 aa)
DVU_3057Oxygen-independent coproporphyrinogen III oxidase, putative; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. (497 aa)
rimOMiaB-like tRNA modifying enzyme YliG, TIGR01125; Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12; Belongs to the methylthiotransferase family. RimO subfamily. (430 aa)
DVU_3241Conserved hypothetical protein; Identified by similarity to OMNI:NTL03CP0990; match to protein family HMM PF01171. (248 aa)
DVU_3291Glutamate synthase, iron-sulfur cluster-binding subunit, putative; Identified by match to protein family HMM PF00037; match to protein family HMM PF01645; Belongs to the glutamate synthase family. (544 aa)
ilvDDihydroxy-acid dehydratase; Identified by similarity to SP:P51785; match to protein family HMM PF00920; match to protein family HMM TIGR00110; Belongs to the IlvD/Edd family. (554 aa)
Your Current Organism:
Desulfovibrio vulgaris Hildenborough
NCBI taxonomy Id: 882
Other names: D. vulgaris str. Hildenborough, Desulfovibrio vulgaris (STRAIN HILDENBOROUGH), Desulfovibrio vulgaris ATCC 29579, Desulfovibrio vulgaris str. Hildenborough, Desulfovibrio vulgaris subsp. vulgaris (strain Hildenborough), Desulfovibrio vulgaris subsp. vulgaris ATCC 29579, Desulfovibrio vulgaris subsp. vulgaris str. Hildenborough
Server load: medium (46%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.