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fumC fumC DVU_0152 DVU_0152 DVU_0246 DVU_0246 DVU_0390 DVU_0390 DVU_0414 DVU_0414 ldh ldh glcB glcB acs acs acyP acyP lpdA lpdA porA porA porB porB DVU_1833 DVU_1833 DVU_1834 DVU_1834 DVU_1914 DVU_1914 DVU_1945 DVU_1945 DVU_1946 DVU_1946 DVU_2225 DVU_2225 DVU_2250 DVU_2250 DVU_2272 DVU_2272 pyk pyk DVU_2739 DVU_2739 DVU_2765 DVU_2765 DVU_2824 DVU_2824 acsA acsA leuA leuA poR poR pta pta ackA ackA DVU_3214 DVU_3214 DVU_3237 DVU_3237 frdC frdC fdrA fdrA frdB frdB DVU_3264 DVU_3264 DVU_3265 DVU_3265 DVU_3348 DVU_3348 DVU_3349 DVU_3349
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
fumCFumarate hydratase, class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (468 aa)
DVU_0152Phosphoenolpyruvate synthase-related protein; Identified by similarity to SP:P42850; match to protein family HMM PF00391; match to protein family HMM PF01326. (853 aa)
DVU_0246Pyruvate phosphate dikinase, PEP/pyruvate binding domain protein; Identified by similarity to SP:O29548; match to protein family HMM PF00391; match to protein family HMM PF01326. (744 aa)
DVU_0390Glycolate oxidase, subunit GlcD, putative; Identified by match to protein family HMM PF01565; match to protein family HMM PF02913. (460 aa)
DVU_0414NADP-dependent malic enzyme-related protein; Identified by match to protein family HMM PF00390; match to protein family HMM PF03949. (439 aa)
ldhL-lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family. (309 aa)
glcBMalate synthase G; Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl- CoA) and glyoxylate to form malate and CoA; Belongs to the malate synthase family. GlcB subfamily. (729 aa)
acsacetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. (648 aa)
acyPAcylphosphatase; Identified by match to protein family HMM PF00708. (100 aa)
lpdA2-oxoglutarate dehydrogenase, E3 component, lipoamide dehydrogenase; Identified by similarity to SP:O34324; match to protein family HMM PF00070; match to protein family HMM PF02852. (456 aa)
porAPyruvate ferredoxin oxidoreductase, alpha subunit; Identified by similarity to GP:43498; match to protein family HMM PF01558; match to protein family HMM PF01855. (578 aa)
porBPyruvate ferredoxin oxidoreductase, beta subunit; Identified by similarity to GP:1565184. (284 aa)
DVU_1833Phosphoenolpyruvate synthase, putative; Identified by match to protein family HMM PF00391; match to protein family HMM PF01326; match to protein family HMM PF02896. (1191 aa)
DVU_1834Pyruvate carboxylase, putative; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1225 aa)
DVU_19142-isopropylmalate synthase/homocitrate synthase family protein; Identified by match to protein family HMM PF00682; match to protein family HMM TIGR00977; Belongs to the alpha-IPM synthase/homocitrate synthase family. (538 aa)
DVU_1945Pyruvate ferredoxin oxidoreductase, alpha subunit, putative; Identified by match to protein family HMM PF01855. (382 aa)
DVU_1946Pyruvate ferredoxin oxidoreductase, beta subunit, putative; Identified by match to protein family HMM PF02775. (276 aa)
DVU_2225acetyl-CoA carboxylase, carboxyl transferase, alpha/beta subunit. (751 aa)
DVU_2250Identified by match to protein family HMM PF00501. (551 aa)
DVU_2272Formate acetyltransferase, putative; Identified by similarity to SP:P32674; match to protein family HMM PF01228; match to protein family HMM PF02901. (817 aa)
pykPyruvate kinase; Identified by match to protein family HMM PF00224; match to protein family HMM PF02887; match to protein family HMM TIGR01064; Belongs to the pyruvate kinase family. (469 aa)
DVU_2739Pyruvate phosphate dikinase, PEP/pyruvate binding domain protein; Identified by similarity to SP:O29548; match to protein family HMM PF00391; match to protein family HMM PF01326. (945 aa)
DVU_2765Identified by match to protein family HMM PF00753. (208 aa)
DVU_2824Formate acetyltransferase; Identified by match to protein family HMM PF01228; match to protein family HMM PF02901. (828 aa)
acsAacetoacetyl-CoA synthase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. (661 aa)
leuA2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (509 aa)
poRPyruvate-ferredoxin oxidoreductase; Identified by similarity to GP:1770208; match to protein family HMM PF00037; match to protein family HMM PF01558; match to protein family HMM PF01855. (1215 aa)
ptaPhosphate acetyltransferase; Involved in acetate metabolism; In the N-terminal section; belongs to the CobB/CobQ family. (704 aa)
ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (402 aa)
DVU_3214Phosphoenolpyruvate synthase-related protein; Identified by similarity to SP:P42850; match to protein family HMM PF00391; match to protein family HMM PF01326. (884 aa)
DVU_3237Phosphoenolpyruvate synthase-related protein; Identified by similarity to SP:P23538; match to protein family HMM PF00391. (773 aa)
frdCFumarate reductase, cytochrome b subunit; Identified by similarity to SP:P17413. (216 aa)
fdrAFumarate reductase, flavoprotein subunit; Identified by similarity to GP:13160058; match to protein family HMM PF00890; match to protein family HMM PF02910; match to protein family HMM TIGR01812. (612 aa)
frdBFumarate reductase, iron-sulfur protein; Identified by similarity to SP:P17596; match to protein family HMM PF00037; match to protein family HMM TIGR00384. (247 aa)
DVU_3264Tartrate dehydratase alpha subunit, putative; Identified by similarity to SP:P05847; match to protein family HMM PF05681; match to protein family HMM TIGR00722. (279 aa)
DVU_3265Tartrate dehydratase beta subunit, putative; Identified by match to protein family HMM PF05683; match to protein family HMM TIGR00723. (183 aa)
DVU_3348Pyruvate ferredoxin/flavodoxin oxidoreductase, beta subunit, putative. (245 aa)
DVU_3349Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-binding domain protein; Identified by match to protein family HMM PF01855. (357 aa)
Your Current Organism:
Desulfovibrio vulgaris Hildenborough
NCBI taxonomy Id: 882
Other names: D. vulgaris str. Hildenborough, Desulfovibrio vulgaris (STRAIN HILDENBOROUGH), Desulfovibrio vulgaris ATCC 29579, Desulfovibrio vulgaris str. Hildenborough, Desulfovibrio vulgaris subsp. vulgaris (strain Hildenborough), Desulfovibrio vulgaris subsp. vulgaris ATCC 29579, Desulfovibrio vulgaris subsp. vulgaris str. Hildenborough
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