(97 nodes) Death-like domain superfamily, and Toll-like Receptor Cascades network (Anas platyrhynchos)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	U3HZQ3_ANAPP	Uncharacterized protein; Belongs to the peptidase C14A family. (268 aa)
	TLR5	TIR domain-containing protein; Belongs to the Toll-like receptor family. (878 aa)
	TIRAP	TIR domain containing adaptor protein. (219 aa)
	TLR6	Toll like receptor 6; Belongs to the Toll-like receptor family. (818 aa)
	TNFAIP3	TNF alpha induced protein 3. (870 aa)
	U3I3J8_ANAPP	Uncharacterized protein. (207 aa)
	TAB3	TGF-beta activated kinase 1 (MAP3K7) binding protein 3. (630 aa)
	BCL10	CARD domain-containing protein. (316 aa)
	U3I7D8_ANAPP	AGC-kinase C-terminal domain-containing protein. (53 aa)
	IRAK2	Interleukin 1 receptor associated kinase 2. (731 aa)
	CARD11	Caspase recruitment domain family member 11. (1187 aa)
	TLR7	Toll like receptor 7; Belongs to the Toll-like receptor family. (1089 aa)
	MAP3K14	Mitogen-activated protein kinase kinase kinase 14. (944 aa)
	CD180	CD180 molecule. (660 aa)
	LY96	Lymphocyte antigen 96. (155 aa)
	CASP2	Caspase 2; Belongs to the peptidase C14A family. (426 aa)
	FADD	Uncharacterized protein. (195 aa)
	U3IBK2_ANAPP	Uncharacterized protein. (566 aa)
	AVEN	Apoptosis and caspase activation inhibitor. (359 aa)
	FASLG	Fas ligand; Belongs to the tumor necrosis factor family. (237 aa)
	BIRC2	Uncharacterized protein. (611 aa)
	U3IDI2_ANAPP	Uncharacterized protein. (357 aa)
	TRAF5	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (557 aa)
	REL	REL proto-oncogene, NF-kB subunit. (592 aa)
	DIABLO	Uncharacterized protein. (241 aa)
	RIPK2	Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (552 aa)
	CARD9	Caspase recruitment domain family member 9. (518 aa)
	TANK	TRAF family member associated NFKB activator. (481 aa)
	MAP3K20-2	SAM domain-containing protein. (549 aa)
	TBK1	TANK binding kinase 1. (600 aa)
	CASP9	Caspase 9; Belongs to the peptidase C14A family. (446 aa)
	TLR3	Toll like receptor 3; Belongs to the Toll-like receptor family. (914 aa)
	MAP3K8	Mitogen-activated protein kinase kinase kinase 8. (487 aa)
	TLR-15	TIR domain-containing protein. (863 aa)
	MALT1	MALT1 paracaspase. (816 aa)
	APAF1	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1247 aa)
	BOK	Uncharacterized protein. (213 aa)
	U3ITT3_ANAPP	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
	NFKBIA	ANK_REP_REGION domain-containing protein. (318 aa)
	TLR2	Toll like receptor 2; Belongs to the Toll-like receptor family. (713 aa)
	BCL2L15	BCL2 like 15. (156 aa)
	BCL2L11	BCL2 like 11. (159 aa)
	TLR4	Toll like receptor 4. (843 aa)
	UNC93B1	Uncharacterized protein. (654 aa)
	CASP7	Caspase 7; Belongs to the peptidase C14A family. (309 aa)
	MAP3K20	Mitogen-activated protein kinase kinase kinase 20. (452 aa)
	TNIP3	TNFAIP3 interacting protein 3. (397 aa)
	U3J3X4_ANAPP	LRRCT domain-containing protein. (553 aa)
	CASP8	Caspase 8; Belongs to the peptidase C14A family. (466 aa)
	CRADD	CASP2 and RIPK1 domain containing adaptor with death domain. (197 aa)
	CASP3	Caspase 3; Belongs to the peptidase C14A family. (306 aa)
	U3J6D9_ANAPP	Uncharacterized protein; Belongs to the peptidase C14A family. (457 aa)
	CASP10	Caspase 10; Belongs to the peptidase C14A family. (538 aa)
	CFLAR	CASP8 and FADD like apoptosis regulator; Belongs to the peptidase C14A family. (489 aa)
	NFKBIE	NFKB inhibitor epsilon. (357 aa)
	U3J6Z6_ANAPP	Uncharacterized protein. (427 aa)
	RIPK1	Receptor interacting serine/threonine kinase 1. (690 aa)
	BIRC7	Baculoviral IAP repeat containing 7. (440 aa)
	TAB1	TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (531 aa)
	TNFSF10	TNF superfamily member 10; Belongs to the tumor necrosis factor family. (295 aa)
	NFKB2	Nuclear factor kappa B subunit 2. (845 aa)
	ENSAPLP00000017975	Uncharacterized protein. (51 aa)
	NFKB1	Nuclear factor kappa B subunit 1. (998 aa)
	ENSAPLP00000018963	TIR domain-containing protein. (795 aa)
	FAS	Uncharacterized protein. (461 aa)
	LY86	Lymphocyte antigen 86. (161 aa)
	RNF11	Ring finger protein 11. (154 aa)
	BCL2	BCL2 apoptosis regulator. (239 aa)
	BCL2L10	Uncharacterized protein. (89 aa)
	ENSAPLP00000021206	DUF4203 domain-containing protein. (110 aa)
	TOLLIP	Toll interacting protein. (310 aa)
	ENSAPLP00000022617	Uncharacterized protein. (721 aa)
	IRAK4	Interleukin 1 receptor associated kinase 4. (541 aa)
	NOD1	Nucleotide binding oligomerization domain containing 1. (951 aa)
	MAP3K7	Mitogen-activated protein kinase kinase kinase 7. (644 aa)
	TRAF2	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (533 aa)
	ENSAPLP00000024408	Uncharacterized protein. (442 aa)
	TRADD	TNFRSF1A associated via death domain. (429 aa)
	XIAP	X-linked inhibitor of apoptosis. (493 aa)
	CHUK	Component of inhibitor of nuclear factor kappa B kinase complex. (757 aa)
	TAX1BP1	Tax1 binding protein 1. (816 aa)
	BCL2L1	BCL2 like 1. (238 aa)
	ENSAPLP00000026904	ANK_REP_REGION domain-containing protein. (188 aa)
	TRAF1	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (570 aa)
	TRAF6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (545 aa)
	MYD88	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (311 aa)
	TAB2	TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (706 aa)
	TRAF3	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (567 aa)
	IKBKB	Inhibitor of nuclear factor kappa B kinase subunit beta. (778 aa)
	ENSAPLP00000030826	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (121 aa)
	TICAM1	TRIF-NTD domain-containing protein. (507 aa)
	PIDD1	P53-induced death domain protein 1. (892 aa)
	MCL1	MCL1 apoptosis regulator, BCL2 family member. (325 aa)
	ENSAPLP00000031408	TIR domain-containing protein. (102 aa)
	CNPY3	Canopy FGF signaling regulator 3. (609 aa)
	CSTB	Cystatin B; Belongs to the cystatin family. (98 aa)
	PLEKHG5	Pleckstrin homology and RhoGEF domain containing G5. (489 aa)

Your Current Organism:

Anas platyrhynchos

NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APAF1	AVEN	ENSAPLP00000010171	ENSAPLP00000004654	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Apoptosis and caspase activation inhibitor.	0.963
APAF1	BCL2	ENSAPLP00000010171	ENSAPLP00000019939	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	BCL2 apoptosis regulator.	0.927
APAF1	BCL2L1	ENSAPLP00000010171	ENSAPLP00000025626	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	BCL2 like 1.	0.873
APAF1	BCL2L10	ENSAPLP00000010171	ENSAPLP00000020198	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Uncharacterized protein.	0.670
APAF1	BCL2L11	ENSAPLP00000010171	ENSAPLP00000011514	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	BCL2 like 11.	0.503
APAF1	BIRC2	ENSAPLP00000010171	ENSAPLP00000004985	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Uncharacterized protein.	0.781
APAF1	BIRC7	ENSAPLP00000010171	ENSAPLP00000016488	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Baculoviral IAP repeat containing 7.	0.705
APAF1	BOK	ENSAPLP00000010171	ENSAPLP00000010265	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Uncharacterized protein.	0.670
APAF1	CASP10	ENSAPLP00000010171	ENSAPLP00000015101	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase 10; Belongs to the peptidase C14A family.	0.881
APAF1	CASP2	ENSAPLP00000010171	ENSAPLP00000004419	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase 2; Belongs to the peptidase C14A family.	0.917
APAF1	CASP3	ENSAPLP00000010171	ENSAPLP00000015062	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase 3; Belongs to the peptidase C14A family.	0.960
APAF1	CASP7	ENSAPLP00000010171	ENSAPLP00000013223	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase 7; Belongs to the peptidase C14A family.	0.929
APAF1	CASP8	ENSAPLP00000010171	ENSAPLP00000014720	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase 8; Belongs to the peptidase C14A family.	0.935
APAF1	CASP9	ENSAPLP00000010171	ENSAPLP00000008534	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase 9; Belongs to the peptidase C14A family.	0.999
APAF1	CFLAR	ENSAPLP00000010171	ENSAPLP00000015177	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	CASP8 and FADD like apoptosis regulator; Belongs to the peptidase C14A family.	0.799
APAF1	DIABLO	ENSAPLP00000010171	ENSAPLP00000006428	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Uncharacterized protein.	0.953
APAF1	ENSAPLP00000021206	ENSAPLP00000010171	ENSAPLP00000021206	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	DUF4203 domain-containing protein.	0.760
APAF1	ENSAPLP00000030826	ENSAPLP00000010171	ENSAPLP00000030826	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.999
APAF1	FADD	ENSAPLP00000010171	ENSAPLP00000004592	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Uncharacterized protein.	0.602
APAF1	FASLG	ENSAPLP00000010171	ENSAPLP00000004898	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Fas ligand; Belongs to the tumor necrosis factor family.	0.563