(18 nodes) Endothelial cell proliferation network (Anas platyrhynchos)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CAV1	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1066 aa)
	FGF7	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
	NOX5	NADPH oxidase 5. (727 aa)
	LOXL2	Lysyl oxidase like 2. (789 aa)
	ITGB1BP1	Integrin subunit beta 1 binding protein 1. (200 aa)
	PRKX	Uncharacterized protein. (345 aa)
	BMPR2	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1000 aa)
	TGFBR1	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
	PROK2	Prokineticin 2. (132 aa)
	TEK	TEK receptor tyrosine kinase. (1128 aa)
	PROK1	Prokineticin 1. (125 aa)
	ENSAPLP00000023501	SRCR domain-containing protein. (269 aa)
	NRARP	NOTCH regulated ankyrin repeat protein. (114 aa)
	SCARB1	Scavenger receptor class B member 1; Belongs to the CD36 family. (504 aa)
	CAV2	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (161 aa)
	XBP1	X-box binding protein 1. (313 aa)
	BMPER	BMP binding endothelial regulator. (784 aa)

Your Current Organism:

Anas platyrhynchos

NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BMPER	BMPR2	ENSAPLP00000032136	ENSAPLP00000007813	BMP binding endothelial regulator.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.471
BMPR2	BMPER	ENSAPLP00000007813	ENSAPLP00000032136	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	BMP binding endothelial regulator.	0.471
BMPR2	TGFBR1	ENSAPLP00000007813	ENSAPLP00000009690	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.622
CAV1	CAV2	ENSAPLP00000001402	ENSAPLP00000030555	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.996
CAV2	CAV1	ENSAPLP00000030555	ENSAPLP00000001402	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.996
FGF7	PIK3CB	ENSAPLP00000003842	ENSAPLP00000003138	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.414
FGF7	TEK	ENSAPLP00000003842	ENSAPLP00000012690	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	TEK receptor tyrosine kinase.	0.771
PIK3CB	FGF7	ENSAPLP00000003138	ENSAPLP00000003842	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.414
PIK3CB	TEK	ENSAPLP00000003138	ENSAPLP00000012690	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	TEK receptor tyrosine kinase.	0.588
TEK	FGF7	ENSAPLP00000012690	ENSAPLP00000003842	TEK receptor tyrosine kinase.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.771
TEK	PIK3CB	ENSAPLP00000012690	ENSAPLP00000003138	TEK receptor tyrosine kinase.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.588
TGFBR1	BMPR2	ENSAPLP00000009690	ENSAPLP00000007813	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.622