(40 nodes) Negative regulation of cytokine-mediated signaling pathway network (Anas platyrhynchos)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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white nodes:
second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Predicted Interactions

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Your Input:
	ENSAPLP00000023471	Uncharacterized protein. (169 aa)
	ENSAPLP00000031406	RING-type domain-containing protein. (172 aa)
	ENSAPLP00000030943	Poly [ADP-ribose] polymerase. (1906 aa)
	IL1R2	Interleukin 1 receptor type 2. (423 aa)
	YTHDF2	YTH N6-methyladenosine RNA binding protein 2. (603 aa)
	SIGIRR	Single Ig and TIR domain containing. (454 aa)
	ENSAPLP00000027532	Link domain-containing protein. (79 aa)
	CYLD	CYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family. (970 aa)
	MUL1	Mitochondrial E3 ubiquitin protein ligase 1. (175 aa)
	ENSAPLP00000024620	Uncharacterized protein. (309 aa)
	ENSAPLP00000024056	SH2 domain-containing protein. (621 aa)
	SH2B3	SH2B adaptor protein 3. (580 aa)
	RABGEF1	Uncharacterized protein. (532 aa)
	ENSAPLP00000019441	Poly [ADP-ribose] polymerase. (1828 aa)
	ENSAPLP00000018983	Uncharacterized protein. (405 aa)
	SLIT2	Slit guidance ligand 2. (1528 aa)
	NLRC5	NLR family CARD domain containing 5. (1891 aa)
	BIRC7	Baculoviral IAP repeat containing 7. (440 aa)
	SLIT3	Slit guidance ligand 3. (1321 aa)
	PADI2	Peptidyl arginine deiminase 2. (664 aa)
	SAMHD1	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1. (573 aa)
	GAS6	Growth arrest specific 6. (724 aa)
	ADIPOQ	Adiponectin, C1Q and collagen domain containing. (245 aa)
	NR1H4	Nuclear receptor subfamily 1 group H member 4. (439 aa)
	U3IYL3_ANAPP	Uncharacterized protein. (591 aa)
	IL6ST	Interleukin 6 signal transducer. (933 aa)
	OTUD4	OTU deubiquitinase 4. (1042 aa)
	CNOT7	CCR4-NOT transcription complex subunit 7. (285 aa)
	YTHDF3	YTH N6-methyladenosine RNA binding protein 3. (583 aa)
	PIAS4	Protein inhibitor of activated STAT 4. (485 aa)
	ADAR	Adenosine deaminase RNA specific. (1164 aa)
	PTPN2	Tyrosine-protein phosphatase non-receptor type. (432 aa)
	STAP1	Signal transducing adaptor family member 1. (316 aa)
	TTLL12	Tubulin tyrosine ligase like 12. (627 aa)
	U3IMS8_ANAPP	Uncharacterized protein; Belongs to the peptidase C19 family. (807 aa)
	CACTIN	Cactin, spliceosome C complex subunit. (706 aa)
	TRAIP	Uncharacterized protein. (375 aa)
	U3I6F1_ANAPP	Uncharacterized protein. (513 aa)
	OTOP1	Otopetrin 1. (587 aa)
	CAV1	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)

Your Current Organism:

Anas platyrhynchos

NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADAR	CAV1	ENSAPLP00000009404	ENSAPLP00000001402	Adenosine deaminase RNA specific.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.438
ADAR	SAMHD1	ENSAPLP00000009404	ENSAPLP00000014458	Adenosine deaminase RNA specific.	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1.	0.644
BIRC7	CYLD	ENSAPLP00000016488	ENSAPLP00000027424	Baculoviral IAP repeat containing 7.	CYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family.	0.491
BIRC7	U3IMS8_ANAPP	ENSAPLP00000016488	ENSAPLP00000008551	Baculoviral IAP repeat containing 7.	Uncharacterized protein; Belongs to the peptidase C19 family.	0.491
CAV1	ADAR	ENSAPLP00000001402	ENSAPLP00000009404	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Adenosine deaminase RNA specific.	0.438
CNOT7	YTHDF2	ENSAPLP00000011100	ENSAPLP00000028274	CCR4-NOT transcription complex subunit 7.	YTH N6-methyladenosine RNA binding protein 2.	0.459
CNOT7	YTHDF3	ENSAPLP00000011100	ENSAPLP00000011064	CCR4-NOT transcription complex subunit 7.	YTH N6-methyladenosine RNA binding protein 3.	0.459
CYLD	BIRC7	ENSAPLP00000027424	ENSAPLP00000016488	CYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family.	Baculoviral IAP repeat containing 7.	0.491
CYLD	U3IMS8_ANAPP	ENSAPLP00000027424	ENSAPLP00000008551	CYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family.	Uncharacterized protein; Belongs to the peptidase C19 family.	0.903
ENSAPLP00000023471	YTHDF2	ENSAPLP00000023471	ENSAPLP00000028274	Uncharacterized protein.	YTH N6-methyladenosine RNA binding protein 2.	0.748
ENSAPLP00000023471	YTHDF3	ENSAPLP00000023471	ENSAPLP00000011064	Uncharacterized protein.	YTH N6-methyladenosine RNA binding protein 3.	0.586
ENSAPLP00000024056	IL6ST	ENSAPLP00000024056	ENSAPLP00000011758	SH2 domain-containing protein.	Interleukin 6 signal transducer.	0.482
ENSAPLP00000024056	PIAS4	ENSAPLP00000024056	ENSAPLP00000010609	SH2 domain-containing protein.	Protein inhibitor of activated STAT 4.	0.484
ENSAPLP00000024056	PTPN2	ENSAPLP00000024056	ENSAPLP00000009354	SH2 domain-containing protein.	Tyrosine-protein phosphatase non-receptor type.	0.543
ENSAPLP00000027532	IL6ST	ENSAPLP00000027532	ENSAPLP00000011758	Link domain-containing protein.	Interleukin 6 signal transducer.	0.482
ENSAPLP00000027532	PIAS4	ENSAPLP00000027532	ENSAPLP00000010609	Link domain-containing protein.	Protein inhibitor of activated STAT 4.	0.484
ENSAPLP00000027532	PTPN2	ENSAPLP00000027532	ENSAPLP00000009354	Link domain-containing protein.	Tyrosine-protein phosphatase non-receptor type.	0.543
ENSAPLP00000031406	TRAIP	ENSAPLP00000031406	ENSAPLP00000003650	RING-type domain-containing protein.	Uncharacterized protein.	0.888
ENSAPLP00000031406	U3I6F1_ANAPP	ENSAPLP00000031406	ENSAPLP00000002822	RING-type domain-containing protein.	Uncharacterized protein.	0.642
IL6ST	ENSAPLP00000024056	ENSAPLP00000011758	ENSAPLP00000024056	Interleukin 6 signal transducer.	SH2 domain-containing protein.	0.482