(52 nodes) Positive regulation of endothelial cell migration network (Anas platyrhynchos)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

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protein homology

Your Input:
	ITGB3	Integrin beta; Belongs to the integrin beta chain family. (1055 aa)
	SIRT1	Sirtuin 1. (777 aa)
	BCAR1	BCAR1 scaffold protein, Cas family member. (918 aa)
	ATOH8	Atonal bHLH transcription factor 8. (214 aa)
	ROCK2	Rho associated coiled-coil containing protein kinase 2; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1488 aa)
	ANXA1	Annexin. (341 aa)
	SASH1	SAM and SH3 domain containing 1. (1270 aa)
	SP1	Sp1 transcription factor. (683 aa)
	RIN2	Ras and Rab interactor 2; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (1392 aa)
	ENSAPLP00000026309	Uncharacterized protein. (68 aa)
	BSG	Basigin (Ok blood group). (377 aa)
	NFE2L2	Nuclear factor, erythroid 2 like 2. (640 aa)
	ENSAPLP00000023757	Protein kinase domain-containing protein. (598 aa)
	BCAS3	BCAS3 microtubule associated cell migration factor. (914 aa)
	ETS1	ETS proto-oncogene 1, transcription factor. (491 aa)
	ANGPT4	Angiopoietin 4. (434 aa)
	THBS1	Thrombospondin 1. (1178 aa)
	IGF2	Insulin like growth factor 2. (224 aa)
	ZC3H12A	Zinc finger CCCH-type containing 12A. (675 aa)
	P2RX4	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (397 aa)
	ENSAPLP00000016895	Uncharacterized protein. (72 aa)
	CD40	TNFR-Cys domain-containing protein. (214 aa)
	AGT	Angiotensinogen; Belongs to the serpin family. (608 aa)
	NUS1	NUS1 dehydrodolichyl diphosphate synthase subunit. (183 aa)
	PDGFB	Platelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (251 aa)
	MAP3K3	Mitogen-activated protein kinase kinase kinase 3. (586 aa)
	TEK	TEK receptor tyrosine kinase. (1128 aa)
	CCBE1	Collagen and calcium binding EGF domains 1. (578 aa)
	ATP5F1A	ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. (553 aa)
	GPLD1	Glycosylphosphatidylinositol specific phospholipase D1. (714 aa)
	MET	MET proto-oncogene, receptor tyrosine kinase. (1382 aa)
	GPI	Glucose-6-phosphate isomerase; Belongs to the GPI family. (553 aa)
	FGF18	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (276 aa)
	GATA3	GATA binding protein 3. (712 aa)
	PIK3CD	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1046 aa)
	TSTA3	Tissue specific transplantation antigen P35B. (321 aa)
	BMPR2	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1000 aa)
	LGMN	Legumain. (431 aa)
	U3IJT1_ANAPP	Protein kinase domain-containing protein. (313 aa)
	ADAM17	ADAM metallopeptidase domain 17. (836 aa)
	ANGPT1	Angiopoietin 1. (498 aa)
	PLPP3	acidPPc domain-containing protein. (313 aa)
	FGF2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (105 aa)
	ITGB1BP1	Integrin subunit beta 1 binding protein 1. (200 aa)
	FGF1	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
	PIK3CG	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1106 aa)
	JCAD	Junctional cadherin 5 associated. (1332 aa)
	FLT4	Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1373 aa)
	KDR	Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1345 aa)
	VEGFC	Vascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (418 aa)
	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1066 aa)
	FGFBP1	Fibroblast growth factor binding protein 1. (211 aa)

Your Current Organism:

Anas platyrhynchos

NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANGPT1	ENSAPLP00000016895	ENSAPLP00000007005	ENSAPLP00000016895	Angiopoietin 1.	Uncharacterized protein.	0.569
ANGPT1	FGF18	ENSAPLP00000007005	ENSAPLP00000009824	Angiopoietin 1.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.518
ANGPT1	FGF2	ENSAPLP00000007005	ENSAPLP00000006620	Angiopoietin 1.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.715
ANGPT1	FLT4	ENSAPLP00000007005	ENSAPLP00000005535	Angiopoietin 1.	Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.835
ANGPT1	KDR	ENSAPLP00000007005	ENSAPLP00000005293	Angiopoietin 1.	Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.894
ANGPT1	MET	ENSAPLP00000007005	ENSAPLP00000010756	Angiopoietin 1.	MET proto-oncogene, receptor tyrosine kinase.	0.680
ANGPT1	PDGFB	ENSAPLP00000007005	ENSAPLP00000013819	Angiopoietin 1.	Platelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family.	0.611
ANGPT1	TEK	ENSAPLP00000007005	ENSAPLP00000012690	Angiopoietin 1.	TEK receptor tyrosine kinase.	0.992
ANGPT1	THBS1	ENSAPLP00000007005	ENSAPLP00000022073	Angiopoietin 1.	Thrombospondin 1.	0.510
ANGPT1	U3IJT1_ANAPP	ENSAPLP00000007005	ENSAPLP00000007503	Angiopoietin 1.	Protein kinase domain-containing protein.	0.549
ANGPT1	VEGFC	ENSAPLP00000007005	ENSAPLP00000005042	Angiopoietin 1.	Vascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family.	0.611
ANGPT4	FLT4	ENSAPLP00000022241	ENSAPLP00000005535	Angiopoietin 4.	Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.761
ANGPT4	KDR	ENSAPLP00000022241	ENSAPLP00000005293	Angiopoietin 4.	Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.786
ANGPT4	MET	ENSAPLP00000022241	ENSAPLP00000010756	Angiopoietin 4.	MET proto-oncogene, receptor tyrosine kinase.	0.669
ANGPT4	TEK	ENSAPLP00000022241	ENSAPLP00000012690	Angiopoietin 4.	TEK receptor tyrosine kinase.	0.992
ATP5F1A	GPI	ENSAPLP00000011290	ENSAPLP00000009916	ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane.	Glucose-6-phosphate isomerase; Belongs to the GPI family.	0.729
BCAR1	ITGB3	ENSAPLP00000030651	ENSAPLP00000004048	BCAR1 scaffold protein, Cas family member.	Integrin beta; Belongs to the integrin beta chain family.	0.559
BCAR1	KDR	ENSAPLP00000030651	ENSAPLP00000005293	BCAR1 scaffold protein, Cas family member.	Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.415
CCBE1	FLT4	ENSAPLP00000012360	ENSAPLP00000005535	Collagen and calcium binding EGF domains 1.	Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.671
CCBE1	U3IJT1_ANAPP	ENSAPLP00000012360	ENSAPLP00000007503	Collagen and calcium binding EGF domains 1.	Protein kinase domain-containing protein.	0.592