(51 nodes) Regulation of gliogenesis network (Anas platyrhynchos)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	TMEM98	Transmembrane protein 98. (117 aa)
	NOG	Noggin; Belongs to the noggin family. (223 aa)
	DLX1	Distal-less homeobox 1. (255 aa)
	SOX8	SRY-box transcription factor 8. (459 aa)
	WNT2	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (319 aa)
	TP73	Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. (656 aa)
	ASPA	Aspartoacylase. (319 aa)
	NOTCH1	Uncharacterized protein. (2250 aa)
	VEGFC	Vascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (418 aa)
	LYN	Tyrosine-protein kinase. (535 aa)
	NF2	Neurofibromin 2. (495 aa)
	PLAG1	PLAG1 zinc finger. (501 aa)
	MTOR	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2538 aa)
	RB1	RB transcriptional corepressor 1. (855 aa)
	ABCC8	ATP binding cassette subfamily C member 8. (1594 aa)
	SKI	SKI proto-oncogene. (744 aa)
	NTN1	Netrin 1. (708 aa)
	U3IQR1_ANAPP	FERM domain-containing protein. (662 aa)
	U3IS84_ANAPP	IF rod domain-containing protein; Belongs to the intermediate filament family. (208 aa)
	U3IWK3_ANAPP	Uncharacterized protein. (578 aa)
	IL6ST	Interleukin 6 signal transducer. (933 aa)
	DAAM2	Dishevelled associated activator of morphogenesis 2. (1097 aa)
	CTNNB1	Catenin beta 1. (781 aa)
	U3J1S1_ANAPP	Uncharacterized protein. (494 aa)
	F2	Uncharacterized protein; Belongs to the peptidase S1 family. (602 aa)
	WNT2B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (385 aa)
	RNF10	Ring finger protein 10. (802 aa)
	MDK	Midkine. (142 aa)
	ENSAPLP00000016724	CCHC-type domain-containing protein. (299 aa)
	GFAP	IF rod domain-containing protein; Belongs to the intermediate filament family. (363 aa)
	SERPINE2	Serpin family E member 2; Belongs to the serpin family. (442 aa)
	HDAC1	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (506 aa)
	ENSAPLP00000020265	Uncharacterized protein. (462 aa)
	ENSAPLP00000020419	NR LBD domain-containing protein. (101 aa)
	IL6	Uncharacterized protein. (350 aa)
	OLIG2	Oligodendrocyte transcription factor 2. (183 aa)
	LINGO1	Leucine rich repeat and Ig domain containing 1. (792 aa)
	ENSAPLP00000021662	Uncharacterized protein. (72 aa)
	PTPRZ1	Protein-tyrosine-phosphatase. (1478 aa)
	OLIG3	Oligodendrocyte transcription factor 3. (273 aa)
	GSX2	GS homeobox 2. (272 aa)
	SLC7A5	Solute carrier family 7 member 5. (532 aa)
	NKX6-1	NK6 homeobox 1. (245 aa)
	ENSAPLP00000026276	SAC domain-containing protein. (479 aa)
	NKX6-2	NK6 homeobox 2. (278 aa)
	ENSAPLP00000028254	Uncharacterized protein. (320 aa)
	SPINT1	Uncharacterized protein. (524 aa)
	ENSAPLP00000031018	Uncharacterized protein. (338 aa)
	DAAM1	Dishevelled associated activator of morphogenesis 1. (1200 aa)
	LIF	LIF interleukin 6 family cytokine. (257 aa)
	TENM4	Teneurin transmembrane protein 4. (2752 aa)

Your Current Organism:

Anas platyrhynchos

NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CTNNB1	ENSAPLP00000020265	ENSAPLP00000013346	ENSAPLP00000020265	Catenin beta 1.	Uncharacterized protein.	0.493
CTNNB1	ENSAPLP00000028254	ENSAPLP00000013346	ENSAPLP00000028254	Catenin beta 1.	Uncharacterized protein.	0.519
CTNNB1	HDAC1	ENSAPLP00000013346	ENSAPLP00000019850	Catenin beta 1.	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.619
CTNNB1	IL6	ENSAPLP00000013346	ENSAPLP00000020478	Catenin beta 1.	Uncharacterized protein.	0.426
CTNNB1	NOTCH1	ENSAPLP00000013346	ENSAPLP00000004270	Catenin beta 1.	Uncharacterized protein.	0.519
CTNNB1	SOX8	ENSAPLP00000013346	ENSAPLP00000002677	Catenin beta 1.	SRY-box transcription factor 8.	0.558
CTNNB1	WNT2	ENSAPLP00000013346	ENSAPLP00000002708	Catenin beta 1.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.539
CTNNB1	WNT2B	ENSAPLP00000013346	ENSAPLP00000014414	Catenin beta 1.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.539
DAAM1	DAAM2	ENSAPLP00000031034	ENSAPLP00000011865	Dishevelled associated activator of morphogenesis 1.	Dishevelled associated activator of morphogenesis 2.	0.901
DAAM2	DAAM1	ENSAPLP00000011865	ENSAPLP00000031034	Dishevelled associated activator of morphogenesis 2.	Dishevelled associated activator of morphogenesis 1.	0.901
ENSAPLP00000020265	CTNNB1	ENSAPLP00000020265	ENSAPLP00000013346	Uncharacterized protein.	Catenin beta 1.	0.493
ENSAPLP00000020265	GFAP	ENSAPLP00000020265	ENSAPLP00000018818	Uncharacterized protein.	IF rod domain-containing protein; Belongs to the intermediate filament family.	0.598
ENSAPLP00000020265	IL6	ENSAPLP00000020265	ENSAPLP00000020478	Uncharacterized protein.	Uncharacterized protein.	0.963
ENSAPLP00000020265	U3IS84_ANAPP	ENSAPLP00000020265	ENSAPLP00000010107	Uncharacterized protein.	IF rod domain-containing protein; Belongs to the intermediate filament family.	0.598
ENSAPLP00000020265	U3J1S1_ANAPP	ENSAPLP00000020265	ENSAPLP00000013448	Uncharacterized protein.	Uncharacterized protein.	0.539
ENSAPLP00000020265	VEGFC	ENSAPLP00000020265	ENSAPLP00000005042	Uncharacterized protein.	Vascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family.	0.450
ENSAPLP00000021662	ENSAPLP00000026276	ENSAPLP00000021662	ENSAPLP00000026276	Uncharacterized protein.	SAC domain-containing protein.	0.919
ENSAPLP00000021662	U3IWK3_ANAPP	ENSAPLP00000021662	ENSAPLP00000011629	Uncharacterized protein.	Uncharacterized protein.	0.899
ENSAPLP00000026276	ENSAPLP00000021662	ENSAPLP00000026276	ENSAPLP00000021662	SAC domain-containing protein.	Uncharacterized protein.	0.919
ENSAPLP00000026276	U3IWK3_ANAPP	ENSAPLP00000026276	ENSAPLP00000011629	SAC domain-containing protein.	Uncharacterized protein.	0.900