STRINGSTRING
EIF3L EIF3L GEMIN4 GEMIN4 CELF2 CELF2 DDX28 DDX28 RPL38 RPL38 SNRPC SNRPC CPSF6 CPSF6 ENSAPLP00000024949 ENSAPLP00000024949 EIF3G EIF3G SMN1 SMN1 ZNHIT2 ZNHIT2 SNRPF SNRPF EIF5 EIF5 ENSAPLP00000026123 ENSAPLP00000026123 ISY1 ISY1 SF3A3 SF3A3 MRM2 MRM2 BTBD19 BTBD19 PUF60 PUF60 POLR2D POLR2D ZNHIT3 ZNHIT3 MCTS1 MCTS1 EIF3H EIF3H RPS5 RPS5 PTGES3 PTGES3 CPSF7 CPSF7 ENSAPLP00000028885 ENSAPLP00000028885 ENSAPLP00000029002 ENSAPLP00000029002 ENSAPLP00000029709 ENSAPLP00000029709 CELF4 CELF4 SRPK2 SRPK2 RRP7A RRP7A EIF3B EIF3B RPS15 RPS15 PRPF18 PRPF18 RAMAC RAMAC PTBP2 PTBP2 RPSA RPSA ENSAPLP00000031814 ENSAPLP00000031814 SHQ1 SHQ1 SF3A2 SF3A2 PIH1D2 PIH1D2 CELF5 CELF5 NUFIP1 NUFIP1 PRMT7 PRMT7 SNRNP200 SNRNP200 SF3B1 SF3B1 NLE1 NLE1 SNRPG SNRPG RPL24 RPL24 DENR DENR ZNHIT6 ZNHIT6 RPS27L RPS27L CDC73 CDC73 SRPK1 SRPK1 NAF1 NAF1 EIF3D EIF3D PRPF3 PRPF3 MDN1 MDN1 U3HZW8_ANAPP U3HZW8_ANAPP SNU13 SNU13 RPS28 RPS28 RPL23A RPL23A RUVBL1 RUVBL1 EIF3E EIF3E FASTKD2 FASTKD2 SART3 SART3 EIF3M EIF3M CLNS1A CLNS1A BRIX1 BRIX1 EIF3A EIF3A GEMIN5 GEMIN5 LUC7L LUC7L TRAF7 TRAF7 MRPS7 MRPS7 C1H12orf45 C1H12orf45 EIF3J EIF3J SNRPD3 SNRPD3 RPF2 RPF2 SF3A1 SF3A1 EIF4H EIF4H DHX29 DHX29 ADAR ADAR USP39 USP39 PRPF8 PRPF8 U3ISD0_ANAPP U3ISD0_ANAPP AGO2 AGO2 PRPF39 PRPF39 AGO4 AGO4 STRAP STRAP EIF2S3 EIF2S3 SNRPB SNRPB PSIP1 PSIP1 GEMIN2 GEMIN2 NUDT21 NUDT21 SNRPD1 SNRPD1 DICER1 DICER1 XRCC5 XRCC5 RPLP0 RPLP0 MRPS11 MRPS11 CRNKL1 CRNKL1 EIF3I EIF3I DDX20 DDX20 MRTO4 MRTO4 RPS14 RPS14 KHDC4 KHDC4 EIF2D EIF2D ERAL1 ERAL1 LUC7L3 LUC7L3 DHX30 DHX30 RPL6 RPL6 RPL5 RPL5 SETX SETX ENSAPLP00000016573 ENSAPLP00000016573 ENSAPLP00000016704 ENSAPLP00000016704 EIF3F EIF3F CELF1 CELF1 GEMIN8 GEMIN8 NOP2 NOP2 SFSWAP SFSWAP ZRSR2 ZRSR2 LSM4 LSM4 ENSAPLP00000019022 ENSAPLP00000019022 ENSAPLP00000019050 ENSAPLP00000019050 RPS19 RPS19 PRPF19 PRPF19 MRPL20 MRPL20 PRPF6 PRPF6 CLP1 CLP1 SCAF11 SCAF11 YTHDC1 YTHDC1 SPATA6 SPATA6 EIF3K EIF3K EIF6 EIF6 ENSAPLP00000022907 ENSAPLP00000022907
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EIF3LEukaryotic translation initiation factor 3 subunit L; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. (653 aa)
GEMIN4Gem nuclear organelle associated protein 4. (1051 aa)
CELF2CUGBP Elav-like family member 2. (530 aa)
DDX28DEAD-box helicase 28. (526 aa)
RPL38Uncharacterized protein; Belongs to the eukaryotic ribosomal protein eL38 family. (112 aa)
SNRPCU1 small nuclear ribonucleoprotein C; Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region. Belongs to the U1 [...] (147 aa)
CPSF6RRM domain-containing protein. (582 aa)
ENSAPLP00000024949Uncharacterized protein. (222 aa)
EIF3GEukaryotic translation initiation factor 3 subunit G; RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. This subunit can bind 18S rRNA. (321 aa)
SMN1Tudor domain-containing protein. (261 aa)
ZNHIT2Zinc finger HIT-type containing 2. (560 aa)
SNRPFSmall nuclear ribonucleoprotein polypeptide F. (89 aa)
EIF5Eukaryotic translation initiation factor 5. (430 aa)
ENSAPLP00000026123Uncharacterized protein. (192 aa)
ISY1Uncharacterized protein. (278 aa)
SF3A3Splicing factor 3a subunit 3. (532 aa)
MRM2FtsJ domain-containing protein. (236 aa)
BTBD19BTB domain containing 19. (316 aa)
PUF60Poly(U) binding splicing factor 60. (542 aa)
POLR2DRPOL4c domain-containing protein. (188 aa)
ZNHIT3Zinc finger HIT-type containing 3. (165 aa)
MCTS1Malignant T-cell-amplified sequence. (161 aa)
EIF3HEukaryotic translation initiation factor 3 subunit H; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. (418 aa)
RPS5Ribosomal protein S5; Belongs to the universal ribosomal protein uS7 family. (276 aa)
PTGES3Prostaglandin E synthase 3. (342 aa)
CPSF7Cleavage and polyadenylation specific factor 7. (595 aa)
ENSAPLP00000028885Uncharacterized protein. (95 aa)
ENSAPLP00000029002Uncharacterized protein. (154 aa)
ENSAPLP00000029709Uncharacterized protein. (55 aa)
CELF4CUGBP Elav-like family member 4. (457 aa)
SRPK2SRSF protein kinase 2. (738 aa)
RRP7ARibosomal RNA processing 7 homolog A. (151 aa)
EIF3BEukaryotic translation initiation factor 3 subunit B; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome; Belongs to the eIF-3 subunit B family. (849 aa)
RPS15Ribosomal protein S15; Belongs to the universal ribosomal protein uS19 family. (158 aa)
PRPF18SFM domain-containing protein. (351 aa)
RAMACUncharacterized protein. (117 aa)
PTBP2Polypyrimidine tract binding protein 2. (578 aa)
RPSA40S ribosomal protein SA; Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA- precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Belongs to the universal ribosomal protein uS2 family. (297 aa)
ENSAPLP00000031814RRM domain-containing protein. (529 aa)
SHQ1SHQ1, H/ACA ribonucleoprotein assembly factor. (577 aa)
SF3A2Splicing factor 3a subunit 2. (315 aa)
PIH1D2PIH1_CS domain-containing protein. (180 aa)
CELF5CUGBP Elav-like family member 5. (494 aa)
NUFIP1Nuclear FMR1 interacting protein 1. (525 aa)
PRMT7Protein arginine N-methyltransferase; Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Specifically mediates the symmetric dimethylation of histone H4 'Arg-3' to form H4R3me2s. Plays a role in gene imprinting by being r [...] (688 aa)
SNRNP200Small nuclear ribonucleoprotein U5 subunit 200. (2085 aa)
SF3B1Splicing factor 3b subunit 1. (1178 aa)
NLE1Notchless homolog 1. (461 aa)
SNRPGSmall nuclear ribonucleoprotein polypeptide G. (61 aa)
RPL24Ribosomal protein L24. (157 aa)
DENRDensity-regulated protein; Belongs to the DENR family. (182 aa)
ZNHIT6Zinc finger HIT-type containing 6. (284 aa)
RPS27L40S ribosomal protein S27. (84 aa)
CDC73Cell division cycle 73. (531 aa)
SRPK1SRSF protein kinase 1. (664 aa)
NAF1Nuclear assembly factor 1 ribonucleoprotein. (473 aa)
EIF3DEukaryotic translation initiation factor 3 subunit D. (396 aa)
PRPF3Pre-mRNA processing factor 3. (678 aa)
MDN1Midasin; Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits; Belongs to the midasin family. (5548 aa)
U3HZW8_ANAPPRRM domain-containing protein. (82 aa)
SNU13Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family. (133 aa)
RPS28Ribosomal protein S28. (69 aa)
RPL23AUncharacterized protein; Belongs to the universal ribosomal protein uL23 family. (70 aa)
RUVBL1RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (456 aa)
EIF3EEukaryotic translation initiation factor 3 subunit E; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. (445 aa)
FASTKD2FAST kinase domains 2. (641 aa)
SART3Spliceosome associated factor 3, U4/U6 recycling protein. (941 aa)
EIF3MEukaryotic translation initiation factor 3 subunit M; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. (374 aa)
CLNS1AUncharacterized protein. (114 aa)
BRIX1Biogenesis of ribosomes BRX1. (348 aa)
EIF3AEukaryotic translation initiation factor 3 subunit A; RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. (1194 aa)
GEMIN5Gem nuclear organelle associated protein 5. (1532 aa)
LUC7LLUC7 like. (348 aa)
TRAF7TNF receptor associated factor 7. (507 aa)
MRPS7Mitochondrial ribosomal protein S7. (233 aa)
C1H12orf45Uncharacterized protein. (154 aa)
EIF3JEukaryotic translation initiation factor 3 subunit J; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. (293 aa)
SNRPD3Small nuclear ribonucleoprotein Sm D3. (126 aa)
RPF2Ribosome production factor 2 homolog. (306 aa)
SF3A1Splicing factor 3a subunit 1. (738 aa)
EIF4HEukaryotic translation initiation factor 4H. (251 aa)
DHX29ATP-dependent RNA helicase DHX29; ATP-binding RNA helicase involved in translation initiation. Part of the 43S pre-initiation complex that is required for efficient initiation on mRNAs of higher eukaryotes with structured 5'-UTRs by promoting efficient NTPase-dependent 48S complex formation. Specifically binds to the 40S ribosome near the mRNA entrance. Does not possess a processive helicase activity; Belongs to the DEAD box helicase family. DEAH subfamily. (1209 aa)
ADARAdenosine deaminase RNA specific. (1164 aa)
USP39Ubiquitin specific peptidase 39. (467 aa)
PRPF8Pre-mRNA processing factor 8. (2241 aa)
U3ISD0_ANAPPUncharacterized protein. (888 aa)
AGO2Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include ago2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] (864 aa)
PRPF39Pre-mRNA processing factor 39. (674 aa)
AGO4Protein argonaute-4; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs; Belongs to the argonaute family. Ago subfamily. (861 aa)
STRAPSerine/threonine kinase receptor associated protein. (804 aa)
EIF2S3Tr-type G domain-containing protein. (472 aa)
SNRPBSmall nuclear ribonucleoprotein-associated protein. (222 aa)
PSIP1PC4 and SFRS1 interacting protein 1. (534 aa)
GEMIN2Gem-associated protein 2; The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs; Belongs to the gemin-2 family. (263 aa)
NUDT21Nudix hydrolase 21. (272 aa)
SNRPD1Small nuclear ribonucleoprotein Sm D1; Essential for pre-mRNA splicing. Implicated in the formation of stable, biologically active snRNP structures. Belongs to the snRNP core protein family. (119 aa)
DICER1Dicer 1, ribonuclease III; Belongs to the helicase family. Dicer subfamily. (1921 aa)
XRCC5X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. (725 aa)
RPLP060S acidic ribosomal protein P0; Ribosomal protein P0 is the functional equivalent of E.coli protein L10. (318 aa)
MRPS11Mitochondrial ribosomal protein S11; Belongs to the universal ribosomal protein uS11 family. (175 aa)
CRNKL1Crooked neck pre-mRNA splicing factor 1. (686 aa)
EIF3IEukaryotic translation initiation factor 3 subunit I; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. (329 aa)
DDX20DEAD-box helicase 20; Belongs to the DEAD box helicase family. (771 aa)
MRTO4Ribosome assembly factor mrt4; Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes. (237 aa)
RPS14Ribosomal protein S14. (154 aa)
KHDC4KH domain containing 4, pre-mRNA splicing factor. (618 aa)
EIF2DEukaryotic translation initiation factor 2D. (599 aa)
ERAL1Era like 12S mitochondrial rRNA chaperone 1. (434 aa)
LUC7L3LUC7 like 3 pre-mRNA splicing factor. (400 aa)
DHX30DExH-box helicase 30. (883 aa)
RPL660S ribosomal protein L6; Belongs to the eukaryotic ribosomal protein eL6 family. (276 aa)
RPL5Ribosomal_L18_c domain-containing protein. (246 aa)
SETXSenataxin. (2815 aa)
ENSAPLP00000016573RRM domain-containing protein. (278 aa)
ENSAPLP00000016704Uncharacterized protein; Belongs to the eukaryotic ribosomal protein eL38 family. (202 aa)
EIF3FEukaryotic translation initiation factor 3 subunit F; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. (481 aa)
CELF1CUGBP Elav-like family member 1. (446 aa)
GEMIN8Gem nuclear organelle associated protein 8. (240 aa)
NOP2SAM_MT_RSMB_NOP domain-containing protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (693 aa)
SFSWAPSplicing factor SWAP. (1042 aa)
ZRSR2Zinc finger CCCH-type, RNA binding motif and serine/arginine rich 2. (282 aa)
LSM4U6 snRNA-associated Sm-like protein LSm4; Binds specifically to the 3'-terminal U-tract of U6 snRNA. (138 aa)
ENSAPLP00000019022Uncharacterized protein. (87 aa)
ENSAPLP00000019050Uncharacterized protein. (391 aa)
RPS19Uncharacterized protein. (88 aa)
PRPF19Pre-mRNA processing factor 19. (191 aa)
MRPL20Mitochondrial ribosomal protein L20; Belongs to the bacterial ribosomal protein bL20 family. (149 aa)
PRPF6Pre-mRNA processing factor 6. (973 aa)
CLP1Polyribonucleotide 5'-hydroxyl-kinase Clp1; Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Appears to have roles in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex. Phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing; thi [...] (425 aa)
SCAF11SR-related CTD associated factor 11. (1412 aa)
YTHDC1YTH domain containing 1. (750 aa)
SPATA6Spermatogenesis associated 6. (497 aa)
EIF3KEukaryotic translation initiation factor 3 subunit K. (123 aa)
EIF6Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis. (283 aa)
ENSAPLP00000022907PCI domain-containing protein; Belongs to the eIF-3 subunit C family. (305 aa)
Your Current Organism:
Anas platyrhynchos
NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard
Server load: low (28%) [HD]