(93 nodes) Intracellular receptor signaling pathway network (Anas platyrhynchos)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	NR2F1	Nuclear receptor subfamily 2 group F member 1. (249 aa)
	NR2E3	Nuclear receptor subfamily 2 group E member 3. (406 aa)
	U3I5X9_ANAPP	NR LBD domain-containing protein. (287 aa)
	PGR	Progesterone receptor. (800 aa)
	UBR5	UBR-type domain-containing protein. (1953 aa)
	RNF34	Ring finger protein 34. (346 aa)
	ESR1	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (548 aa)
	PPARD	Peroxisome proliferator activated receptor delta. (381 aa)
	U3IBF2_ANAPP	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (596 aa)
	U3IBK2_ANAPP	Uncharacterized protein. (566 aa)
	VDR	Vitamin D receptor. (472 aa)
	LACC1	Uncharacterized protein. (438 aa)
	NR1D2	Nuclear receptor subfamily 1 group D member 2. (623 aa)
	RORA	RAR related orphan receptor A. (485 aa)
	THRB	Thyroid hormone receptor beta. (476 aa)
	OTULIN	OTU deubiquitinase with linear linkage specificity. (402 aa)
	AR	Androgen receptor. (385 aa)
	CRKL	CRK like proto-oncogene, adaptor protein. (301 aa)
	RIPK2	Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (552 aa)
	NR3C1	Nuclear receptor subfamily 3 group C member 1. (820 aa)
	U3IL74_ANAPP	Uncharacterized protein. (502 aa)
	PPARG	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (450 aa)
	DDX5	DEAD-box helicase 5; Belongs to the DEAD box helicase family. (582 aa)
	LSM14A	LSM14A mRNA processing body assembly factor. (461 aa)
	RWDD1	RWD domain containing 1. (285 aa)
	PDK3	Protein-serine/threonine kinase. (406 aa)
	PPARA	Peroxisome proliferator activated receptor alpha. (447 aa)
	IFIH1	Interferon induced with helicase C domain 1. (1003 aa)
	NR1H3	Nuclear receptor subfamily 1 group H member 3. (409 aa)
	U3IVJ4_ANAPP	Uncharacterized protein. (465 aa)
	CYP7B1	Cytochrome P450 family 7 subfamily B member 1; Belongs to the cytochrome P450 family. (504 aa)
	HNF4G	Hepatocyte nuclear factor 4 gamma. (407 aa)
	ESR2	Estrogen receptor 2. (554 aa)
	U3IX85_ANAPP	Uncharacterized protein. (178 aa)
	FAM120B	Family with sequence similarity 120B. (701 aa)
	DHX58	DExH-box helicase 58. (1068 aa)
	RXRA	Retinoid X receptor alpha. (418 aa)
	GPER1	G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (357 aa)
	NR1H4	Nuclear receptor subfamily 1 group H member 4. (439 aa)
	ALPK1	Alpha kinase 1. (1197 aa)
	TMF1	TATA element modulatory factor 1. (1159 aa)
	AHRR	Uncharacterized protein. (946 aa)
	UBE3A	Ubiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. (880 aa)
	TRERF1	Transcriptional regulating factor 1. (1167 aa)
	DDX58	DExD/H-box helicase 58. (880 aa)
	NR3C2	Nuclear receptor subfamily 3 group C member 2. (1012 aa)
	PADI2	Peptidyl arginine deiminase 2. (664 aa)
	SNW1	SNW domain containing 1. (538 aa)
	ENSAPLP00000017159	Uncharacterized protein. (259 aa)
	ENSAPLP00000017261	Uncharacterized protein. (460 aa)
	NR4A2	Nuclear receptor subfamily 4 group A member 2. (216 aa)
	NR2F2	NR LBD domain-containing protein. (414 aa)
	RORB	RAR related orphan receptor B. (416 aa)
	RBFOX2	RNA binding fox-1 homolog 2. (490 aa)
	ENSAPLP00000019159	Uncharacterized protein. (424 aa)
	ENSAPLP00000019390	Nuclear receptor domain-containing protein. (171 aa)
	ENSAPLP00000019430	ATPase_AAA_core domain-containing protein. (232 aa)
	PPARGC1B	PPARG coactivator 1 beta. (1020 aa)
	ENSAPLP00000020419	NR LBD domain-containing protein. (101 aa)
	RARB	Retinoic acid receptor beta. (455 aa)
	OTULINL	OTU deubiquitinase with linear linkage specificity like. (429 aa)
	RORC	RAR related orphan receptor C. (658 aa)
	PTF1A	Pancreas associated transcription factor 1a. (275 aa)
	TIFA	TRAF interacting protein with forkhead associated domain. (119 aa)
	NR5A2	Nuclear receptor subfamily 5 group A member 2. (541 aa)
	MED1	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1474 aa)
	DDX17	DEAD-box helicase 17; Belongs to the DEAD box helicase family. (655 aa)
	ESRRB	Estrogen related receptor beta. (458 aa)
	ESRRG	Estrogen related receptor gamma. (488 aa)
	INAVA	Innate immunity activator. (388 aa)
	RARA	Retinoic acid receptor alpha. (215 aa)
	NR2F6	Nuclear receptor subfamily 2 group F member 6. (441 aa)
	ENSAPLP00000023999	PAS domain-containing protein. (956 aa)
	NKX3-1	NK3 homeobox 1. (280 aa)
	HNF4A	Hepatocyte nuclear factor 4 alpha. (481 aa)
	NR2C2	Nuclear receptor subfamily 2 group C member 2. (872 aa)
	ENSAPLP00000024647	Uncharacterized protein. (520 aa)
	ENSAPLP00000024744	NR LBD domain-containing protein. (242 aa)
	NR4A3	Nuclear receptor subfamily 4 group A member 3. (753 aa)
	NR5A1	Nuclear receptor subfamily 5 group A member 1. (388 aa)
	NR2E1	NR LBD domain-containing protein. (170 aa)
	NR4A1	Nuclear receptor subfamily 4 group A member 1. (586 aa)
	AHR	Uncharacterized protein. (834 aa)
	THRA	Thyroid hormone receptor alpha. (304 aa)
	RXRG	NR LBD domain-containing protein. (106 aa)
	TRIP4	Thyroid hormone receptor interactor 4. (583 aa)
	ENSAPLP00000030173	Uncharacterized protein. (328 aa)
	ENSAPLP00000030691	HECT domain-containing protein. (79 aa)
	ENSAPLP00000030796	Uncharacterized protein. (1090 aa)
	ACTN4	Actinin alpha 4. (942 aa)
	ENSAPLP00000032061	Uncharacterized protein. (900 aa)
	NR6A1	Nuclear receptor subfamily 6 group A member 1. (454 aa)
	ENSAPLP00000032542	NR LBD domain-containing protein. (114 aa)

Your Current Organism:

Anas platyrhynchos

NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALPK1	TIFA	ENSAPLP00000013302	ENSAPLP00000021429	Alpha kinase 1.	TRAF interacting protein with forkhead associated domain.	0.903
AR	ENSAPLP00000030173	ENSAPLP00000006185	ENSAPLP00000030173	Androgen receptor.	Uncharacterized protein.	0.477
AR	ESR1	ENSAPLP00000006185	ENSAPLP00000004132	Androgen receptor.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.640
AR	MED1	ENSAPLP00000006185	ENSAPLP00000022023	Androgen receptor.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.489
AR	NKX3-1	ENSAPLP00000006185	ENSAPLP00000024179	Androgen receptor.	NK3 homeobox 1.	0.551
AR	NR3C1	ENSAPLP00000006185	ENSAPLP00000006970	Androgen receptor.	Nuclear receptor subfamily 3 group C member 1.	0.607
AR	NR3C2	ENSAPLP00000006185	ENSAPLP00000015040	Androgen receptor.	Nuclear receptor subfamily 3 group C member 2.	0.595
AR	PGR	ENSAPLP00000006185	ENSAPLP00000003406	Androgen receptor.	Progesterone receptor.	0.618
AR	U3IBF2_ANAPP	ENSAPLP00000006185	ENSAPLP00000004574	Androgen receptor.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.489
CRKL	ENSAPLP00000030173	ENSAPLP00000006274	ENSAPLP00000030173	CRK like proto-oncogene, adaptor protein.	Uncharacterized protein.	0.747
CYP7B1	NR1H4	ENSAPLP00000011339	ENSAPLP00000013117	Cytochrome P450 family 7 subfamily B member 1; Belongs to the cytochrome P450 family.	Nuclear receptor subfamily 1 group H member 4.	0.507
DDX17	DDX5	ENSAPLP00000022718	ENSAPLP00000008804	DEAD-box helicase 17; Belongs to the DEAD box helicase family.	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	0.888
DDX17	ESR1	ENSAPLP00000022718	ENSAPLP00000004132	DEAD-box helicase 17; Belongs to the DEAD box helicase family.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.802
DDX17	ESR2	ENSAPLP00000022718	ENSAPLP00000011686	DEAD-box helicase 17; Belongs to the DEAD box helicase family.	Estrogen receptor 2.	0.596
DDX5	DDX17	ENSAPLP00000008804	ENSAPLP00000022718	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	DEAD-box helicase 17; Belongs to the DEAD box helicase family.	0.888
DDX5	ESR1	ENSAPLP00000008804	ENSAPLP00000004132	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.829
DDX5	ESR2	ENSAPLP00000008804	ENSAPLP00000011686	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	Estrogen receptor 2.	0.596
DDX5	SNW1	ENSAPLP00000008804	ENSAPLP00000015649	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	SNW domain containing 1.	0.466
DDX58	DHX58	ENSAPLP00000014969	ENSAPLP00000012991	DExD/H-box helicase 58.	DExH-box helicase 58.	0.837
DDX58	IFIH1	ENSAPLP00000014969	ENSAPLP00000010681	DExD/H-box helicase 58.	Interferon induced with helicase C domain 1.	0.842