(48 nodes) Regulation of actin filament depolymerization network (Anas platyrhynchos)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	XIRP2	LIM zinc-binding domain-containing protein. (150 aa)
	ENSAPLP00000032848	PH domain-containing protein. (1586 aa)
	TWF2	ADF-H domain-containing protein. (176 aa)
	LIMA1	LIM domain and actin binding 1. (857 aa)
	ENSAPLP00000032270	ADF-H domain-containing protein. (357 aa)
	ENSAPLP00000032266	Uncharacterized protein. (1002 aa)
	ENSAPLP00000032006	Calponin-homology (CH) domain-containing protein. (78 aa)
	PLEK	Pleckstrin. (363 aa)
	ENSAPLP00000030881	Uncharacterized protein. (203 aa)
	HSPB1	SHSP domain-containing protein. (517 aa)
	MTPN	Myotrophin. (380 aa)
	ENSAPLP00000025972	PH domain-containing protein. (96 aa)
	CRACD	KIAA1211. (1410 aa)
	DSTN	Destrin, actin depolymerizing factor; Belongs to the actin-binding proteins ADF family. (148 aa)
	ADD1	Adducin 1. (857 aa)
	WDR1	WD repeat domain 1. (628 aa)
	CAPZA2	F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (338 aa)
	CAPG	Capping actin protein, gelsolin like. (508 aa)
	VILL	Villin like. (903 aa)
	CAPZA1	F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (292 aa)
	CAPZB	F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (276 aa)
	SPTB	Spectrin beta chain; Belongs to the spectrin family. (2522 aa)
	TMOD3	Tropomodulin 3. (352 aa)
	U3ILB0_ANAPP	Uncharacterized protein. (3100 aa)
	TMOD2	Tropomodulin 2. (351 aa)
	SPTBN1	Spectrin beta chain; Belongs to the spectrin family. (2083 aa)
	SVIL	Supervillin. (2171 aa)
	SCIN	Scinderin. (717 aa)
	GSN	Gelsolin. (778 aa)
	ADD3	Adducin 3. (710 aa)
	TMOD1	Tropomodulin 1. (359 aa)
	CAPZA3	F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (301 aa)
	PLEKHH2	Pleckstrin homology, MyTH4 and FERM domain containing H2. (1500 aa)
	TWF1	Twinfilin actin binding protein 1. (397 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	LMOD3	Leiomodin 3. (528 aa)
	ADD2	Adducin 2. (649 aa)
	SPTAN1	Spectrin alpha, non-erythrocytic 1. (2433 aa)
	U3J831_ANAPP	Uncharacterized protein. (638 aa)
	LMOD1	Leiomodin 1. (449 aa)
	VIL1	Villin 1. (369 aa)
	CARMIL2	Capping protein regulator and myosin 1 linker 2. (1389 aa)
	RDX	Radixin. (604 aa)
	TMOD4	Tropomodulin 4. (385 aa)
	LMOD2	Leiomodin 2. (553 aa)
	FLII	FLII actin remodeling protein. (1233 aa)
	CARMIL1	Capping protein regulator and myosin 1 linker 1. (1424 aa)
	ENSAPLP00000024887	Uncharacterized protein. (398 aa)

Your Current Organism:

Anas platyrhynchos

NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADD1	ADD2	ENSAPLP00000020706	ENSAPLP00000013444	Adducin 1.	Adducin 2.	0.965
ADD1	ADD3	ENSAPLP00000020706	ENSAPLP00000004056	Adducin 1.	Adducin 3.	0.949
ADD1	CAPZB	ENSAPLP00000020706	ENSAPLP00000024655	Adducin 1.	F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.	0.460
ADD1	RDX	ENSAPLP00000020706	ENSAPLP00000018411	Adducin 1.	Radixin.	0.451
ADD1	TMOD1	ENSAPLP00000020706	ENSAPLP00000002384	Adducin 1.	Tropomodulin 1.	0.630
ADD1	TMOD3	ENSAPLP00000020706	ENSAPLP00000008795	Adducin 1.	Tropomodulin 3.	0.495
ADD2	ADD1	ENSAPLP00000013444	ENSAPLP00000020706	Adducin 2.	Adducin 1.	0.965
ADD2	CAPZB	ENSAPLP00000013444	ENSAPLP00000024655	Adducin 2.	F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.	0.607
ADD2	RDX	ENSAPLP00000013444	ENSAPLP00000018411	Adducin 2.	Radixin.	0.451
ADD2	TMOD1	ENSAPLP00000013444	ENSAPLP00000002384	Adducin 2.	Tropomodulin 1.	0.627
ADD3	ADD1	ENSAPLP00000004056	ENSAPLP00000020706	Adducin 3.	Adducin 1.	0.949
ADD3	CAPZB	ENSAPLP00000004056	ENSAPLP00000024655	Adducin 3.	F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.	0.411
ADD3	RDX	ENSAPLP00000004056	ENSAPLP00000018411	Adducin 3.	Radixin.	0.485
ADD3	TMOD1	ENSAPLP00000004056	ENSAPLP00000002384	Adducin 3.	Tropomodulin 1.	0.636
ADD3	TMOD3	ENSAPLP00000004056	ENSAPLP00000008795	Adducin 3.	Tropomodulin 3.	0.452
CAPG	ENSAPLP00000032270	ENSAPLP00000022226	ENSAPLP00000032270	Capping actin protein, gelsolin like.	ADF-H domain-containing protein.	0.507
CAPG	TMOD1	ENSAPLP00000022226	ENSAPLP00000002384	Capping actin protein, gelsolin like.	Tropomodulin 1.	0.537
CAPG	TMOD2	ENSAPLP00000022226	ENSAPLP00000007990	Capping actin protein, gelsolin like.	Tropomodulin 2.	0.592
CAPG	TMOD3	ENSAPLP00000022226	ENSAPLP00000008795	Capping actin protein, gelsolin like.	Tropomodulin 3.	0.591
CAPG	TWF1	ENSAPLP00000022226	ENSAPLP00000011473	Capping actin protein, gelsolin like.	Twinfilin actin binding protein 1.	0.615