(27 nodes) CD4-positive, alpha-beta T cell activation network (Anas platyrhynchos)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	IL6	Uncharacterized protein. (350 aa)
	U3IBK2_ANAPP	Uncharacterized protein. (566 aa)
	RC3H1	Ring finger and CCCH-type domains 1. (1122 aa)
	RORA	RAR related orphan receptor A. (485 aa)
	RSAD2	Radical S-adenosyl methionine domain containing 2. (345 aa)
	RIPK2	Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (552 aa)
	IL21	Interleukin; Belongs to the IL-15/IL-21 family. (145 aa)
	MTOR	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2538 aa)
	LEF1	Uncharacterized protein. (415 aa)
	IL12B	Interleukin-12 subunit beta; Belongs to the type I cytokine receptor family. Type 3 subfamily. (315 aa)
	TOX	Thymocyte selection associated high mobility group box. (525 aa)
	SEMA4A	Semaphorin 4A; Belongs to the semaphorin family. (701 aa)
	GATA3	GATA binding protein 3. (712 aa)
	ITCH	E3 ubiquitin-protein ligase. (769 aa)
	RC3H2	Ring finger and CCCH-type domains 2. (1191 aa)
	U3J4V3_ANAPP	Homeobox domain-containing protein. (195 aa)
	IL4R	Fibronectin type-III domain-containing protein. (1023 aa)
	IL6R	Interleukin 6 receptor. (415 aa)
	PTGER4	Prostaglandin E receptor 4; Belongs to the G-protein coupled receptor 1 family. (474 aa)
	SASH3	SAM and SH3 domain containing 3. (455 aa)
	CARD11	Caspase recruitment domain family member 11. (1187 aa)
	RORC	RAR related orphan receptor C. (658 aa)
	CD83	CD83 molecule. (218 aa)
	BATF	Basic leucine zipper ATF-like transcription factor. (126 aa)
	CDH26	Cadherin 26. (781 aa)
	ENSAPLP00000032903	HMG box domain-containing protein. (180 aa)
	GPR183	G protein-coupled receptor 183; Belongs to the G-protein coupled receptor 1 family. (368 aa)

Your Current Organism:

Anas platyrhynchos

NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BATF	GATA3	ENSAPLP00000027804	ENSAPLP00000009770	Basic leucine zipper ATF-like transcription factor.	GATA binding protein 3.	0.402
CARD11	RIPK2	ENSAPLP00000003269	ENSAPLP00000006481	Caspase recruitment domain family member 11.	Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains.	0.463
CARD11	U3IBK2_ANAPP	ENSAPLP00000003269	ENSAPLP00000004624	Caspase recruitment domain family member 11.	Uncharacterized protein.	0.463
CD83	IL4R	ENSAPLP00000026016	ENSAPLP00000015125	CD83 molecule.	Fibronectin type-III domain-containing protein.	0.457
CD83	IL6	ENSAPLP00000026016	ENSAPLP00000020478	CD83 molecule.	Uncharacterized protein.	0.566
GATA3	BATF	ENSAPLP00000009770	ENSAPLP00000027804	GATA binding protein 3.	Basic leucine zipper ATF-like transcription factor.	0.402
GATA3	IL21	ENSAPLP00000009770	ENSAPLP00000006533	GATA binding protein 3.	Interleukin; Belongs to the IL-15/IL-21 family.	0.439
GATA3	IL6	ENSAPLP00000009770	ENSAPLP00000020478	GATA binding protein 3.	Uncharacterized protein.	0.549
GATA3	RORC	ENSAPLP00000009770	ENSAPLP00000021062	GATA binding protein 3.	RAR related orphan receptor C.	0.483
IL12B	IL6	ENSAPLP00000008792	ENSAPLP00000020478	Interleukin-12 subunit beta; Belongs to the type I cytokine receptor family. Type 3 subfamily.	Uncharacterized protein.	0.465
IL21	GATA3	ENSAPLP00000006533	ENSAPLP00000009770	Interleukin; Belongs to the IL-15/IL-21 family.	GATA binding protein 3.	0.439
IL21	IL6	ENSAPLP00000006533	ENSAPLP00000020478	Interleukin; Belongs to the IL-15/IL-21 family.	Uncharacterized protein.	0.729
IL4R	CD83	ENSAPLP00000015125	ENSAPLP00000026016	Fibronectin type-III domain-containing protein.	CD83 molecule.	0.457
IL4R	IL6	ENSAPLP00000015125	ENSAPLP00000020478	Fibronectin type-III domain-containing protein.	Uncharacterized protein.	0.466
IL4R	IL6R	ENSAPLP00000015125	ENSAPLP00000017269	Fibronectin type-III domain-containing protein.	Interleukin 6 receptor.	0.549
IL6	CD83	ENSAPLP00000020478	ENSAPLP00000026016	Uncharacterized protein.	CD83 molecule.	0.566
IL6	GATA3	ENSAPLP00000020478	ENSAPLP00000009770	Uncharacterized protein.	GATA binding protein 3.	0.549
IL6	IL12B	ENSAPLP00000020478	ENSAPLP00000008792	Uncharacterized protein.	Interleukin-12 subunit beta; Belongs to the type I cytokine receptor family. Type 3 subfamily.	0.465
IL6	IL21	ENSAPLP00000020478	ENSAPLP00000006533	Uncharacterized protein.	Interleukin; Belongs to the IL-15/IL-21 family.	0.729
IL6	IL4R	ENSAPLP00000020478	ENSAPLP00000015125	Uncharacterized protein.	Fibronectin type-III domain-containing protein.	0.466