(26 nodes) Interstrand cross-link repair network (Anas platyrhynchos)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DCLRE1A	DNA cross-link repair 1A. (1001 aa)
	SLX4	SLX4 structure-specific endonuclease subunit. (1881 aa)
	ENSAPLP00000029564	Uncharacterized protein. (378 aa)
	FANCM	FA complementation group M. (2204 aa)
	FAAP20	Uncharacterized protein. (317 aa)
	ENSAPLP00000025361	Fanconi_A_N domain-containing protein. (1158 aa)
	ENSAPLP00000024809	RAD51_interact domain-containing protein. (1009 aa)
	FANCD2	Uncharacterized protein. (305 aa)
	ERCC1	ERCC excision repair 1, endonuclease non-catalytic subunit. (211 aa)
	NUCKS1	Nuclear casein kinase and cyclin dependent kinase substrate 1. (292 aa)
	FANCF	Uncharacterized protein. (338 aa)
	ENSAPLP00000017886	Fanconi_A_N domain-containing protein. (255 aa)
	FANCC	Fanconi anemia group C protein homolog; DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1. (556 aa)
	ENSAPLP00000017617	Uncharacterized protein. (493 aa)
	FANCL	FA complementation group L. (373 aa)
	XPA	XPA, DNA damage recognition and repair factor. (491 aa)
	RFWD3	Ring finger and WD repeat domain 3. (712 aa)
	ERCC4	ERCC excision repair 4, endonuclease catalytic subunit. (903 aa)
	NEIL3	Nei like DNA glycosylase 3. (581 aa)
	FANCB	FA complementation group B. (853 aa)
	FAN1	Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. (1044 aa)
	FAAP24	FA core complex associated protein 24. (215 aa)
	DCLRE1C	DNA cross-link repair 1C. (716 aa)
	VCP	Valosin containing protein; Belongs to the AAA ATPase family. (855 aa)
	RAD51	DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa)
	RAD51AP1	RAD51 associated protein 1. (400 aa)

Your Current Organism:

Anas platyrhynchos

NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DCLRE1A	ENSAPLP00000017617	ENSAPLP00000013179	ENSAPLP00000017617	DNA cross-link repair 1A.	Uncharacterized protein.	0.490
DCLRE1A	ENSAPLP00000017886	ENSAPLP00000013179	ENSAPLP00000017886	DNA cross-link repair 1A.	Fanconi_A_N domain-containing protein.	0.750
DCLRE1A	ENSAPLP00000025361	ENSAPLP00000013179	ENSAPLP00000025361	DNA cross-link repair 1A.	Fanconi_A_N domain-containing protein.	0.750
DCLRE1A	ERCC1	ENSAPLP00000013179	ENSAPLP00000018553	DNA cross-link repair 1A.	ERCC excision repair 1, endonuclease non-catalytic subunit.	0.712
DCLRE1A	ERCC4	ENSAPLP00000013179	ENSAPLP00000014008	DNA cross-link repair 1A.	ERCC excision repair 4, endonuclease catalytic subunit.	0.682
DCLRE1A	FAAP24	ENSAPLP00000013179	ENSAPLP00000006591	DNA cross-link repair 1A.	FA core complex associated protein 24.	0.700
DCLRE1A	FAN1	ENSAPLP00000013179	ENSAPLP00000006932	DNA cross-link repair 1A.	Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family.	0.814
DCLRE1A	FANCB	ENSAPLP00000013179	ENSAPLP00000012935	DNA cross-link repair 1A.	FA complementation group B.	0.486
DCLRE1A	FANCC	ENSAPLP00000013179	ENSAPLP00000017763	DNA cross-link repair 1A.	Fanconi anemia group C protein homolog; DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1.	0.751
DCLRE1A	FANCD2	ENSAPLP00000013179	ENSAPLP00000022164	DNA cross-link repair 1A.	Uncharacterized protein.	0.810
DCLRE1A	FANCF	ENSAPLP00000013179	ENSAPLP00000017959	DNA cross-link repair 1A.	Uncharacterized protein.	0.548
DCLRE1A	FANCL	ENSAPLP00000013179	ENSAPLP00000016248	DNA cross-link repair 1A.	FA complementation group L.	0.725
DCLRE1A	FANCM	ENSAPLP00000013179	ENSAPLP00000027475	DNA cross-link repair 1A.	FA complementation group M.	0.838
DCLRE1A	RAD51	ENSAPLP00000013179	ENSAPLP00000003989	DNA cross-link repair 1A.	DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...]	0.500
DCLRE1A	SLX4	ENSAPLP00000013179	ENSAPLP00000029602	DNA cross-link repair 1A.	SLX4 structure-specific endonuclease subunit.	0.785
DCLRE1A	XPA	ENSAPLP00000013179	ENSAPLP00000016177	DNA cross-link repair 1A.	XPA, DNA damage recognition and repair factor.	0.614
DCLRE1C	ERCC1	ENSAPLP00000005201	ENSAPLP00000018553	DNA cross-link repair 1C.	ERCC excision repair 1, endonuclease non-catalytic subunit.	0.632
DCLRE1C	ERCC4	ENSAPLP00000005201	ENSAPLP00000014008	DNA cross-link repair 1C.	ERCC excision repair 4, endonuclease catalytic subunit.	0.639
DCLRE1C	FAAP24	ENSAPLP00000005201	ENSAPLP00000006591	DNA cross-link repair 1C.	FA core complex associated protein 24.	0.449
DCLRE1C	FAN1	ENSAPLP00000005201	ENSAPLP00000006932	DNA cross-link repair 1C.	Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family.	0.632