(52 nodes) Regulation of multicellular organism growth network (Anas platyrhynchos)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	TSHR	Thyrotropin receptor; Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (765 aa)
	ENSAPLP00000032786	CCDC144C domain-containing protein. (240 aa)
	GHRHR	Growth hormone releasing hormone receptor; Belongs to the G-protein coupled receptor 2 family. (418 aa)
	SGPL1	Sphingosine-1-phosphate lyase 1. (579 aa)
	CSF1	Uncharacterized protein. (472 aa)
	FXN	Frataxin. (113 aa)
	ENSAPLP00000029056	Uncharacterized protein. (2204 aa)
	ENSAPLP00000027233	TGF_BETA_2 domain-containing protein. (367 aa)
	MKKS	McKusick-Kaufman syndrome. (571 aa)
	ENSAPLP00000025446	Uncharacterized protein. (237 aa)
	ENSAPLP00000024738	Uncharacterized protein. (257 aa)
	FTO	FTO alpha-ketoglutarate dependent dioxygenase. (571 aa)
	ENSAPLP00000023418	PDZ domain-containing protein. (177 aa)
	GAMT	Guanidinoacetate N-methyltransferase. (223 aa)
	BBS2	Bardet-Biedl syndrome 2. (522 aa)
	ENSAPLP00000021502	Uncharacterized protein. (146 aa)
	GHR	Growth hormone receptor. (644 aa)
	ADRB1	Adrenoceptor beta 1. (437 aa)
	IGF2	Insulin like growth factor 2. (224 aa)
	BCL2	BCL2 apoptosis regulator. (239 aa)
	RAI1	Retinoic acid induced 1. (1939 aa)
	PLAC8	Uncharacterized protein. (119 aa)
	GPAT4	Glycerol-3-phosphate acyltransferase 4. (455 aa)
	ENSAPLP00000016822	Uncharacterized protein. (263 aa)
	PRLH	Prolactin releasing hormone. (86 aa)
	BBS4	Bardet-Biedl syndrome 4. (505 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	EZR	Ezrin. (585 aa)
	PRL	Prolactin. (229 aa)
	GHSR	Growth hormone secretagogue receptor; Belongs to the G-protein coupled receptor 1 family. (352 aa)
	PLAC8-2	Placenta associated 8. (113 aa)
	MFSD2A	Major facilitator superfamily domain containing 2A. (528 aa)
	ZMPSTE24	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (465 aa)
	TNKS2	Poly [ADP-ribose] polymerase. (1109 aa)
	MBD5	Methyl-CpG binding domain protein 5. (1735 aa)
	PARP11	Multifunctional fusion protein. (648 aa)
	DRD2	Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family. (446 aa)
	APP	Amyloid beta precursor protein. (717 aa)
	ADRB3	G_PROTEIN_RECEP_F1_2 domain-containing protein. (403 aa)
	NIPBL	Nipped-B protein. (2783 aa)
	LGMN	Legumain. (431 aa)
	STAT3	Signal transducer and activator of transcription. (942 aa)
	SMO	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (620 aa)
	CREB1	cAMP responsive element binding protein 1. (327 aa)
	CHD7	Chromodomain helicase DNA binding protein 7. (2936 aa)
	GHRH	GLUCAGON domain-containing protein. (272 aa)
	GH1	Uncharacterized protein. (222 aa)
	U3I9M3_ANAPP	PDZ domain-containing protein. (165 aa)
	CHD9	Chromodomain helicase DNA binding protein 9. (2862 aa)
	GPAM	Glycerol-3-phosphate acyltransferase 1, mitochondrial. (829 aa)
	ADRB2	Adrenoceptor beta 2. (402 aa)
	SOCS2	Suppressor of cytokine signaling 2. (143 aa)

Your Current Organism:

Anas platyrhynchos

NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADRB1	ADRB2	ENSAPLP00000020974	ENSAPLP00000001151	Adrenoceptor beta 1.	Adrenoceptor beta 2.	0.883
ADRB1	ADRB3	ENSAPLP00000020974	ENSAPLP00000008294	Adrenoceptor beta 1.	G_PROTEIN_RECEP_F1_2 domain-containing protein.	0.886
ADRB2	ADRB1	ENSAPLP00000001151	ENSAPLP00000020974	Adrenoceptor beta 2.	Adrenoceptor beta 1.	0.883
ADRB2	ADRB3	ENSAPLP00000001151	ENSAPLP00000008294	Adrenoceptor beta 2.	G_PROTEIN_RECEP_F1_2 domain-containing protein.	0.886
ADRB3	ADRB1	ENSAPLP00000008294	ENSAPLP00000020974	G_PROTEIN_RECEP_F1_2 domain-containing protein.	Adrenoceptor beta 1.	0.886
ADRB3	ADRB2	ENSAPLP00000008294	ENSAPLP00000001151	G_PROTEIN_RECEP_F1_2 domain-containing protein.	Adrenoceptor beta 2.	0.886
APP	GHRH	ENSAPLP00000008622	ENSAPLP00000004347	Amyloid beta precursor protein.	GLUCAGON domain-containing protein.	0.441
APP	GHSR	ENSAPLP00000008622	ENSAPLP00000011813	Amyloid beta precursor protein.	Growth hormone secretagogue receptor; Belongs to the G-protein coupled receptor 1 family.	0.513
BBS2	BBS4	ENSAPLP00000021916	ENSAPLP00000015890	Bardet-Biedl syndrome 2.	Bardet-Biedl syndrome 4.	0.998
BBS2	SMO	ENSAPLP00000021916	ENSAPLP00000007352	Bardet-Biedl syndrome 2.	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.	0.637
BBS4	BBS2	ENSAPLP00000015890	ENSAPLP00000021916	Bardet-Biedl syndrome 4.	Bardet-Biedl syndrome 2.	0.998
BBS4	SMO	ENSAPLP00000015890	ENSAPLP00000007352	Bardet-Biedl syndrome 4.	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.	0.625
BCL2	CREB1	ENSAPLP00000019939	ENSAPLP00000006421	BCL2 apoptosis regulator.	cAMP responsive element binding protein 1.	0.546
BCL2	ENSAPLP00000024738	ENSAPLP00000019939	ENSAPLP00000024738	BCL2 apoptosis regulator.	Uncharacterized protein.	0.633
BCL2	STAT3	ENSAPLP00000019939	ENSAPLP00000007496	BCL2 apoptosis regulator.	Signal transducer and activator of transcription.	0.830
CREB1	BCL2	ENSAPLP00000006421	ENSAPLP00000019939	cAMP responsive element binding protein 1.	BCL2 apoptosis regulator.	0.546
CREB1	FTO	ENSAPLP00000006421	ENSAPLP00000023662	cAMP responsive element binding protein 1.	FTO alpha-ketoglutarate dependent dioxygenase.	0.562
CREB1	STAT3	ENSAPLP00000006421	ENSAPLP00000007496	cAMP responsive element binding protein 1.	Signal transducer and activator of transcription.	0.530
DRD2	PRL	ENSAPLP00000008760	ENSAPLP00000011821	Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family.	Prolactin.	0.431
ENSAPLP00000016822	ENSAPLP00000023418	ENSAPLP00000016822	ENSAPLP00000023418	Uncharacterized protein.	PDZ domain-containing protein.	0.747