(94 nodes) Regulation of T cell proliferation network (Anas platyrhynchos)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSAPLP00000028034	Ig-like domain-containing protein. (441 aa)
	PELI1	Pellino E3 ubiquitin protein ligase 1. (461 aa)
	SLC7A1	Solute carrier family 7 member 1. (624 aa)
	ENSAPLP00000032345	IGc1 domain-containing protein. (227 aa)
	ENSAPLP00000031536	Ig-like domain-containing protein. (255 aa)
	SCRIB	Scribble planar cell polarity protein. (1751 aa)
	ENSAPLP00000030961	Uncharacterized protein. (149 aa)
	ENSAPLP00000030832	IGc1 domain-containing protein. (252 aa)
	ENSAPLP00000030194	Ig-like domain-containing protein. (126 aa)
	ENSAPLP00000030122	Ig-like domain-containing protein. (260 aa)
	ENSAPLP00000030022	Ig-like domain-containing protein. (330 aa)
	PAWR	Pro-apoptotic WT1 regulator. (208 aa)
	ENSAPLP00000029895	Ig-like domain-containing protein. (157 aa)
	LGALS3	Galectin. (335 aa)
	CD81	Tetraspanin. (467 aa)
	ANXA1	Annexin. (341 aa)
	ENSAPLP00000028629	Ig-like domain-containing protein. (134 aa)
	TRAF6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (545 aa)
	ENSAPLP00000027875	Uncharacterized protein. (105 aa)
	ENSAPLP00000027687	Uncharacterized protein. (83 aa)
	IHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (757 aa)
	NCK2	Cytoplasmic protein. (380 aa)
	ENSAPLP00000027305	IGc1 domain-containing protein. (247 aa)
	MARCHF7	Membrane associated ring-CH-type finger 7. (758 aa)
	CD86	CD86 molecule. (341 aa)
	ENSAPLP00000025986	Phospholipase A(2). (156 aa)
	IL12RB2	Interleukin 12 receptor subunit beta 2. (851 aa)
	CD6	CD6 molecule. (577 aa)
	ENSAPLP00000024589	Ig-like domain-containing protein. (243 aa)
	ENSAPLP00000024133	Uncharacterized protein. (697 aa)
	ENSAPLP00000023833	BaffR-Tall_bind domain-containing protein. (216 aa)
	GLMN	Glomulin, FKBP associated protein. (636 aa)
	ENSAPLP00000023668	Uncharacterized protein. (400 aa)
	DLG5	Discs large MAGUK scaffold protein 5; Belongs to the MAGUK family. (2045 aa)
	ENSAPLP00000023136	Uncharacterized protein. (387 aa)
	SOS2	SOS Ras/Rho guanine nucleotide exchange factor 2. (1331 aa)
	CEBPB	CCAAT/enhancer-binding protein. (306 aa)
	ENSAPLP00000021706	Ig-like domain-containing protein. (243 aa)
	ENSAPLP00000020767	IGc1 domain-containing protein. (274 aa)
	IL23R	Uncharacterized protein. (549 aa)
	IL6	Uncharacterized protein. (350 aa)
	ENSAPLP00000020265	Uncharacterized protein. (462 aa)
	IGF2	Insulin like growth factor 2. (224 aa)
	ENSAPLP00000020171	Ig-like domain-containing protein. (202 aa)
	SASH3	SAM and SH3 domain containing 3. (455 aa)
	ENSAPLP00000019712	Ig-like domain-containing protein. (250 aa)
	TGFBR2	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (575 aa)
	ENSAPLP00000018402	Ig-like domain-containing protein. (279 aa)
	CD276	CD276 molecule. (302 aa)
	VSIR	V-set immunoregulatory receptor. (413 aa)
	ENSAPLP00000017273	SCY domain-containing protein. (182 aa)
	TNFRSF21	Uncharacterized protein. (641 aa)
	ENSAPLP00000016970	Ig-like domain-containing protein. (304 aa)
	ENSAPLP00000016842	Ig-like domain-containing protein. (356 aa)
	ENSAPLP00000016526	Ig-like domain-containing protein. (239 aa)
	MAD1L1	Mitotic arrest deficient 1 like 1. (717 aa)
	ARG2	Arginase. (357 aa)
	VTCN1	V-set domain containing T cell activation inhibitor 1. (268 aa)
	RPS3	KH type-2 domain-containing protein; Belongs to the universal ribosomal protein uS3 family. (243 aa)
	U3J1S1_ANAPP	Uncharacterized protein. (494 aa)
	CTNNB1	Catenin beta 1. (781 aa)
	ITCH	E3 ubiquitin-protein ligase. (769 aa)
	GPNMB	Glycoprotein nmb. (555 aa)
	IL6ST	Interleukin 6 signal transducer. (933 aa)
	CRTAM	Cytotoxic and regulatory T cell molecule. (477 aa)
	TNFRSF9	TNFR-Cys domain-containing protein. (162 aa)
	SOS1	SOS Ras/Rac guanine nucleotide exchange factor 1. (1323 aa)
	LRRC32	Uncharacterized protein. (675 aa)
	IL12B	Interleukin-12 subunit beta; Belongs to the type I cytokine receptor family. Type 3 subfamily. (315 aa)
	TNFSF13B	TNF superfamily member 13b; Belongs to the tumor necrosis factor family. (306 aa)
	PRKAR1A	Protein kinase cAMP-dependent type I regulatory subunit alpha. (382 aa)
	IL21	Interleukin; Belongs to the IL-15/IL-21 family. (145 aa)
	RIPK2	Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (552 aa)
	SH3RF1	SH3 domain containing ring finger 1. (873 aa)
	IL18	Interleukin-18. (197 aa)
	RC3H1	Ring finger and CCCH-type domains 1. (1122 aa)
	U3IBK2_ANAPP	Uncharacterized protein. (566 aa)
	FADD	Uncharacterized protein. (195 aa)
	PTPN6	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (607 aa)
	IL15	Interleukin; Belongs to the IL-15/IL-21 family. (223 aa)
	CD274	Uncharacterized protein. (329 aa)
	PDCD1LG2	Uncharacterized protein. (321 aa)
	NDFIP1	Nedd4 family interacting protein 1. (252 aa)
	CARD11	Caspase recruitment domain family member 11. (1187 aa)
	SYK	Spleen associated tyrosine kinase. (636 aa)
	IL20RB	Interleukin 20 receptor subunit beta. (312 aa)
	TFRC	Transferrin receptor. (775 aa)
	TMEM131L	Transmembrane 131 like. (1532 aa)
	LRRC1	Leucine rich repeat containing 1. (524 aa)
	ZAP70	Tyrosine-protein kinase. (607 aa)
	GPAM	Glycerol-3-phosphate acyltransferase 1, mitochondrial. (829 aa)
	CTLA4	Cytotoxic T-lymphocyte associated protein 4. (185 aa)
	CD28	CD28 molecule. (222 aa)
	U3HYQ0_ANAPP	Ig-like domain-containing protein. (144 aa)

Your Current Organism:

Anas platyrhynchos

NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANXA1	CD81	ENSAPLP00000029030	ENSAPLP00000029304	Annexin.	Tetraspanin.	0.489
ANXA1	LGALS3	ENSAPLP00000029030	ENSAPLP00000029583	Annexin.	Galectin.	0.583
ARG2	ENSAPLP00000030961	ENSAPLP00000015462	ENSAPLP00000030961	Arginase.	Uncharacterized protein.	0.546
ARG2	IL6	ENSAPLP00000015462	ENSAPLP00000020478	Arginase.	Uncharacterized protein.	0.450
CARD11	RIPK2	ENSAPLP00000003269	ENSAPLP00000006481	Caspase recruitment domain family member 11.	Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains.	0.463
CARD11	SYK	ENSAPLP00000003269	ENSAPLP00000003149	Caspase recruitment domain family member 11.	Spleen associated tyrosine kinase.	0.554
CARD11	TRAF6	ENSAPLP00000003269	ENSAPLP00000027926	Caspase recruitment domain family member 11.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.777
CARD11	U3IBK2_ANAPP	ENSAPLP00000003269	ENSAPLP00000004624	Caspase recruitment domain family member 11.	Uncharacterized protein.	0.463
CARD11	ZAP70	ENSAPLP00000003269	ENSAPLP00000001899	Caspase recruitment domain family member 11.	Tyrosine-protein kinase.	0.579
CD274	CD86	ENSAPLP00000004192	ENSAPLP00000026026	Uncharacterized protein.	CD86 molecule.	0.597
CD274	CTLA4	ENSAPLP00000004192	ENSAPLP00000001417	Uncharacterized protein.	Cytotoxic T-lymphocyte associated protein 4.	0.620
CD274	PDCD1LG2	ENSAPLP00000004192	ENSAPLP00000004103	Uncharacterized protein.	Uncharacterized protein.	0.826
CD274	PTPN6	ENSAPLP00000004192	ENSAPLP00000004482	Uncharacterized protein.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.547
CD274	TNFRSF9	ENSAPLP00000004192	ENSAPLP00000010372	Uncharacterized protein.	TNFR-Cys domain-containing protein.	0.508
CD276	CD86	ENSAPLP00000017815	ENSAPLP00000026026	CD276 molecule.	CD86 molecule.	0.586
CD276	CTLA4	ENSAPLP00000017815	ENSAPLP00000001417	CD276 molecule.	Cytotoxic T-lymphocyte associated protein 4.	0.615
CD276	TNFRSF9	ENSAPLP00000017815	ENSAPLP00000010372	CD276 molecule.	TNFR-Cys domain-containing protein.	0.497
CD276	VTCN1	ENSAPLP00000017815	ENSAPLP00000015396	CD276 molecule.	V-set domain containing T cell activation inhibitor 1.	0.425
CD28	CD86	ENSAPLP00000001220	ENSAPLP00000026026	CD28 molecule.	CD86 molecule.	0.995
CD28	CTLA4	ENSAPLP00000001220	ENSAPLP00000001417	CD28 molecule.	Cytotoxic T-lymphocyte associated protein 4.	0.620