(80 nodes) Regulation of lymphocyte differentiation network (Anas platyrhynchos)

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SOCS1	Suppressor of cytokine signaling 1. (207 aa)
	ZBTB1	Zinc finger and BTB domain containing 1. (642 aa)
	RHOH	Ras homolog family member H. (191 aa)
	SMAD7	Mothers against decapentaplegic homolog. (369 aa)
	SOCS5	Suppressor of cytokine signaling 5. (536 aa)
	CTLA4	Cytotoxic T-lymphocyte associated protein 4. (185 aa)
	CARD11	Caspase recruitment domain family member 11. (1187 aa)
	SYK	Spleen associated tyrosine kinase. (636 aa)
	LAG3	Lymphocyte activating 3. (505 aa)
	TMEM131L	Transmembrane 131 like. (1532 aa)
	HLA-DRA	Major histocompatibility complex, class II, DR alpha. (255 aa)
	RC3H1	Ring finger and CCCH-type domains 1. (1122 aa)
	IL18	Interleukin-18. (197 aa)
	SH3RF1	SH3 domain containing ring finger 1. (873 aa)
	SLC46A2	Solute carrier family 46 member 2. (453 aa)
	RASGRP1	RAS guanyl releasing protein 1. (857 aa)
	RIPK2	Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (552 aa)
	LEF1	Uncharacterized protein. (415 aa)
	MYB	MYB proto-oncogene, transcription factor. (762 aa)
	IL7	Uncharacterized protein. (144 aa)
	TOX	Thymocyte selection associated high mobility group box. (525 aa)
	PTPN2	Tyrosine-protein phosphatase non-receptor type. (432 aa)
	GATA3	GATA binding protein 3. (712 aa)
	U3IRD8_ANAPP	Uncharacterized protein. (934 aa)
	MALT1	MALT1 paracaspase. (816 aa)
	SOS1	SOS Ras/Rac guanine nucleotide exchange factor 1. (1323 aa)
	FBXO7	F-box protein 7. (588 aa)
	PPP2R3C	Protein phosphatase 2 regulatory subunit B''gamma. (457 aa)
	CRTAM	Cytotoxic and regulatory T cell molecule. (477 aa)
	FGL2	Fibrinogen like 2. (502 aa)
	GAS6	Growth arrest specific 6. (724 aa)
	RC3H2	Ring finger and CCCH-type domains 2. (1191 aa)
	FOXN1	Forkhead box N1. (655 aa)
	IKZF3	C2H2-type domain-containing protein. (245 aa)
	IL4R	Fibronectin type-III domain-containing protein. (1023 aa)
	IL10	Interleukin 10. (177 aa)
	AMBRA1	Autophagy and beclin 1 regulator 1. (1166 aa)
	MDK	Midkine. (142 aa)
	ENSAPLP00000017273	SCY domain-containing protein. (182 aa)
	ENSAPLP00000017717	Sushi domain-containing protein. (293 aa)
	VSIR	V-set immunoregulatory receptor. (413 aa)
	ENSAPLP00000017886	Fanconi_A_N domain-containing protein. (255 aa)
	BCL6	Uncharacterized protein. (709 aa)
	TGFBR2	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (575 aa)
	SASH3	SAM and SH3 domain containing 3. (455 aa)
	ZC3H12A	Zinc finger CCCH-type containing 12A. (675 aa)
	SOX13	SRY-box transcription factor 13. (700 aa)
	IL7R	Interleukin 7 receptor. (528 aa)
	PRELID1	PRELI domain containing 1. (207 aa)
	ENSAPLP00000021903	Uncharacterized protein. (210 aa)
	FANCD2	Uncharacterized protein. (305 aa)
	INPP5D	SH2 domain-containing protein. (1260 aa)
	ENSAPLP00000022617	Uncharacterized protein. (721 aa)
	PRDM1	PR/SET domain 1. (871 aa)
	SOS2	SOS Ras/Rho guanine nucleotide exchange factor 2. (1331 aa)
	ENSAPLP00000023471	Uncharacterized protein. (169 aa)
	RNF41	Ring finger protein 41. (317 aa)
	NRARP	NOTCH regulated ankyrin repeat protein. (114 aa)
	ENSAPLP00000024498	Fibrinogen C-terminal domain-containing protein. (231 aa)
	ENSAPLP00000025361	Fanconi_A_N domain-containing protein. (1158 aa)
	DUSP10	Dual specificity phosphatase 10. (443 aa)
	CD83	CD83 molecule. (218 aa)
	ZBTB16	Zinc finger and BTB domain containing 16. (574 aa)
	IHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (757 aa)
	ENSAPLP00000027687	Uncharacterized protein. (83 aa)
	ANXA1	Annexin. (341 aa)
	CBFB	Core-binding factor subunit beta. (80 aa)
	PCID2	PCI domain containing 2. (399 aa)
	XBP1	X-box binding protein 1. (313 aa)
	NFAM1	Ig-like domain-containing protein. (248 aa)
	TCF7	Transcription factor 7. (439 aa)
	CD74	CD74 molecule. (300 aa)
	ENSAPLP00000032903	HMG box domain-containing protein. (180 aa)
	ZAP70	Tyrosine-protein kinase. (607 aa)
	PTPN6	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (607 aa)
	IL15	Interleukin; Belongs to the IL-15/IL-21 family. (223 aa)
	DROSHA	Drosha ribonuclease III. (1294 aa)
	NDFIP1	Nedd4 family interacting protein 1. (252 aa)
	U3I8F7_ANAPP	Uncharacterized protein. (439 aa)
	U3IBK2_ANAPP	Uncharacterized protein. (566 aa)

Your Current Organism:

Anas platyrhynchos

NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BCL6	GATA3	ENSAPLP00000018321	ENSAPLP00000009770	Uncharacterized protein.	GATA binding protein 3.	0.557
BCL6	IL10	ENSAPLP00000018321	ENSAPLP00000015242	Uncharacterized protein.	Interleukin 10.	0.429
BCL6	XBP1	ENSAPLP00000018321	ENSAPLP00000030925	Uncharacterized protein.	X-box binding protein 1.	0.675
CARD11	ENSAPLP00000022617	ENSAPLP00000003269	ENSAPLP00000022617	Caspase recruitment domain family member 11.	Uncharacterized protein.	0.854
CARD11	MALT1	ENSAPLP00000003269	ENSAPLP00000009828	Caspase recruitment domain family member 11.	MALT1 paracaspase.	0.980
CARD11	RASGRP1	ENSAPLP00000003269	ENSAPLP00000006065	Caspase recruitment domain family member 11.	RAS guanyl releasing protein 1.	0.572
CARD11	RIPK2	ENSAPLP00000003269	ENSAPLP00000006481	Caspase recruitment domain family member 11.	Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains.	0.463
CARD11	SYK	ENSAPLP00000003269	ENSAPLP00000003149	Caspase recruitment domain family member 11.	Spleen associated tyrosine kinase.	0.554
CARD11	U3IBK2_ANAPP	ENSAPLP00000003269	ENSAPLP00000004624	Caspase recruitment domain family member 11.	Uncharacterized protein.	0.463
CARD11	ZAP70	ENSAPLP00000003269	ENSAPLP00000001899	Caspase recruitment domain family member 11.	Tyrosine-protein kinase.	0.579
CBFB	GATA3	ENSAPLP00000029667	ENSAPLP00000009770	Core-binding factor subunit beta.	GATA binding protein 3.	0.562
CD74	DROSHA	ENSAPLP00000032611	ENSAPLP00000004055	CD74 molecule.	Drosha ribonuclease III.	0.604
CD74	HLA-DRA	ENSAPLP00000032611	ENSAPLP00000004667	CD74 molecule.	Major histocompatibility complex, class II, DR alpha.	0.804
CD74	XBP1	ENSAPLP00000032611	ENSAPLP00000030925	CD74 molecule.	X-box binding protein 1.	0.512
CD83	IL10	ENSAPLP00000026016	ENSAPLP00000015242	CD83 molecule.	Interleukin 10.	0.617
CD83	IL4R	ENSAPLP00000026016	ENSAPLP00000015125	CD83 molecule.	Fibronectin type-III domain-containing protein.	0.457
CRTAM	LAG3	ENSAPLP00000010643	ENSAPLP00000002115	Cytotoxic and regulatory T cell molecule.	Lymphocyte activating 3.	0.508
CTLA4	IL10	ENSAPLP00000001417	ENSAPLP00000015242	Cytotoxic T-lymphocyte associated protein 4.	Interleukin 10.	0.802
CTLA4	IL15	ENSAPLP00000001417	ENSAPLP00000004404	Cytotoxic T-lymphocyte associated protein 4.	Interleukin; Belongs to the IL-15/IL-21 family.	0.587
CTLA4	IL7	ENSAPLP00000001417	ENSAPLP00000008882	Cytotoxic T-lymphocyte associated protein 4.	Uncharacterized protein.	0.437