(55 nodes) Positive regulation of JNK cascade network (Anas platyrhynchos)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	RB1CC1	RB1 inducible coiled-coil 1. (1348 aa)
	U3I1L7_ANAPP	Uncharacterized protein. (199 aa)
	TIRAP	TIR domain containing adaptor protein. (219 aa)
	FGF19	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (226 aa)
	U3IBE4_ANAPP	Uncharacterized protein. (596 aa)
	U3IBK2_ANAPP	Uncharacterized protein. (566 aa)
	NCF1	Neutrophil cytosolic factor 1. (387 aa)
	TNFSF11	TNF superfamily member 11; Belongs to the tumor necrosis factor family. (322 aa)
	FLT4	Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1373 aa)
	SH3RF1	SH3 domain containing ring finger 1. (873 aa)
	AXIN1	Axin 1. (841 aa)
	RASGRP1	RAS guanyl releasing protein 1. (857 aa)
	TRAF5	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (557 aa)
	RIPK2	Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (552 aa)
	CARD9	Caspase recruitment domain family member 9. (518 aa)
	U3IJT1_ANAPP	Protein kinase domain-containing protein. (313 aa)
	APP	Amyloid beta precursor protein. (717 aa)
	TLR3	Toll like receptor 3; Belongs to the Toll-like receptor family. (914 aa)
	DUSP19	Dual specificity phosphatase 19; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (208 aa)
	TNIK	CNH domain-containing protein. (718 aa)
	WNT7B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
	PJA2	RING-type domain-containing protein. (620 aa)
	TAOK1	TAO kinase 1. (1001 aa)
	TAOK3	TAO kinase 3. (898 aa)
	MAP2K4	Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (409 aa)
	NRK	Uncharacterized protein. (1179 aa)
	WNT7A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
	RIPK1	Receptor interacting serine/threonine kinase 1. (690 aa)
	EDAR	Ectodysplasin A receptor. (447 aa)
	U3J9B6_ANAPP	ANK_REP_REGION domain-containing protein. (317 aa)
	CCL19	C-C motif chemokine. (106 aa)
	BIRC7	Baculoviral IAP repeat containing 7. (440 aa)
	ENSAPLP00000017273	SCY domain-containing protein. (182 aa)
	ENSAPLP00000018177	C-C motif chemokine. (134 aa)
	TRAF4	TNF receptor-associated factor. (470 aa)
	ENSAPLP00000018997	Uncharacterized protein. (245 aa)
	SERPINF2	SERPIN domain-containing protein; Belongs to the serpin family. (511 aa)
	SH3RF3	SH3 domain containing ring finger 3. (799 aa)
	ENSAPLP00000023136	Uncharacterized protein. (387 aa)
	ENSAPLP00000023838	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (244 aa)
	NOD1	Nucleotide binding oligomerization domain containing 1. (951 aa)
	TRAF2	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (533 aa)
	ENSAPLP00000024882	DIX domain-containing protein. (189 aa)
	WNT16	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
	MBIP	MAP3K12 binding inhibitory protein 1. (352 aa)
	ENSAPLP00000025738	Uncharacterized protein. (116 aa)
	ENSAPLP00000027533	Uncharacterized protein. (198 aa)
	TRAF1	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (570 aa)
	TRAF6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (545 aa)
	TRAF3	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (567 aa)
	ENSAPLP00000029860	Uncharacterized protein. (277 aa)
	MFHAS1	Malignant fibrous histiocytoma amplified sequence 1. (1009 aa)
	GADD45G	Growth arrest and DNA damage inducible gamma. (238 aa)
	ENSAPLP00000032571	TNFR-Cys domain-containing protein. (677 aa)
	SH3RF2	Uncharacterized protein. (194 aa)

Your Current Organism:

Anas platyrhynchos

NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APP	ENSAPLP00000029860	ENSAPLP00000008622	ENSAPLP00000029860	Amyloid beta precursor protein.	Uncharacterized protein.	0.544
APP	U3J9B6_ANAPP	ENSAPLP00000008622	ENSAPLP00000016094	Amyloid beta precursor protein.	ANK_REP_REGION domain-containing protein.	0.544
AXIN1	WNT7A	ENSAPLP00000005877	ENSAPLP00000013691	Axin 1.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.559
AXIN1	WNT7B	ENSAPLP00000005877	ENSAPLP00000010322	Axin 1.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.525
BIRC7	NOD1	ENSAPLP00000016488	ENSAPLP00000023952	Baculoviral IAP repeat containing 7.	Nucleotide binding oligomerization domain containing 1.	0.480
BIRC7	RIPK1	ENSAPLP00000016488	ENSAPLP00000015290	Baculoviral IAP repeat containing 7.	Receptor interacting serine/threonine kinase 1.	0.707
BIRC7	RIPK2	ENSAPLP00000016488	ENSAPLP00000006481	Baculoviral IAP repeat containing 7.	Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains.	0.538
BIRC7	TRAF1	ENSAPLP00000016488	ENSAPLP00000027725	Baculoviral IAP repeat containing 7.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.722
BIRC7	TRAF2	ENSAPLP00000016488	ENSAPLP00000024259	Baculoviral IAP repeat containing 7.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.722
BIRC7	TRAF3	ENSAPLP00000016488	ENSAPLP00000028635	Baculoviral IAP repeat containing 7.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.597
BIRC7	TRAF5	ENSAPLP00000016488	ENSAPLP00000006206	Baculoviral IAP repeat containing 7.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.597
BIRC7	TRAF6	ENSAPLP00000016488	ENSAPLP00000027926	Baculoviral IAP repeat containing 7.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.574
BIRC7	U3IBK2_ANAPP	ENSAPLP00000016488	ENSAPLP00000004624	Baculoviral IAP repeat containing 7.	Uncharacterized protein.	0.538
CARD9	NOD1	ENSAPLP00000007223	ENSAPLP00000023952	Caspase recruitment domain family member 9.	Nucleotide binding oligomerization domain containing 1.	0.798
CARD9	RIPK2	ENSAPLP00000007223	ENSAPLP00000006481	Caspase recruitment domain family member 9.	Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains.	0.449
EDAR	SH3RF3	ENSAPLP00000015865	ENSAPLP00000021851	Ectodysplasin A receptor.	SH3 domain containing ring finger 3.	0.489
ENSAPLP00000018997	ENSAPLP00000025738	ENSAPLP00000018997	ENSAPLP00000025738	Uncharacterized protein.	Uncharacterized protein.	0.515
ENSAPLP00000018997	SH3RF2	ENSAPLP00000018997	ENSAPLP00000032810	Uncharacterized protein.	Uncharacterized protein.	0.899
ENSAPLP00000023838	TNIK	ENSAPLP00000023838	ENSAPLP00000010292	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	CNH domain-containing protein.	0.900
ENSAPLP00000025738	ENSAPLP00000018997	ENSAPLP00000025738	ENSAPLP00000018997	Uncharacterized protein.	Uncharacterized protein.	0.515