(48 nodes) Regulation of smooth muscle cell proliferation network (Anas platyrhynchos)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	GPER1	G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (357 aa)
	EREG	Epiregulin. (148 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	XRCC5	X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. (725 aa)
	MFN2	Mitofusin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (735 aa)
	CX3CL1	SCY domain-containing protein. (481 aa)
	IL12B	Interleukin-12 subunit beta; Belongs to the type I cytokine receptor family. Type 3 subfamily. (315 aa)
	BMPR2	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1000 aa)
	MNAT1	MNAT1 component of CDK activating kinase. (336 aa)
	DBH	Dopamine beta-hydroxylase. (630 aa)
	VIP	Vasoactive intestinal peptide. (200 aa)
	IL12A	Interleukin-12 subunit alpha; Belongs to the IL-6 superfamily. (214 aa)
	IL18	Interleukin-18. (197 aa)
	SOD2	Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (224 aa)
	APOD	Lipocln_cytosolic_FA-bd_dom domain-containing protein; Belongs to the calycin superfamily. Lipocalin family. (264 aa)
	ITGB3	Integrin beta; Belongs to the integrin beta chain family. (1055 aa)
	MMP2	Matrix metallopeptidase 2. (663 aa)
	GNA12	G protein subunit alpha 12. (385 aa)
	CALCRL	Calcitonin receptor like receptor; Belongs to the G-protein coupled receptor 2 family. (467 aa)
	TNFAIP3	TNF alpha induced protein 3. (870 aa)
	GJA1	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (381 aa)
	SERPINF2	SERPIN domain-containing protein; Belongs to the serpin family. (511 aa)
	IL6	Uncharacterized protein. (350 aa)
	IL6R	Interleukin 6 receptor. (415 aa)
	EDN1	Endothelin 1. (203 aa)
	LDLRAP1	Low density lipoprotein receptor adaptor protein 1. (301 aa)
	U3J8L2_ANAPP	Uncharacterized protein. (803 aa)
	NDRG1	N-myc downstream regulated 1. (396 aa)
	IL10	Interleukin 10. (177 aa)
	VIPR2	Vasoactive intestinal peptide receptor 2; Belongs to the G-protein coupled receptor 2 family. (409 aa)
	DDR2	Discoidin domain receptor tyrosine kinase 2. (855 aa)
	PDGFB	Platelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (251 aa)
	CTNNB1	Catenin beta 1. (781 aa)
	ADIPOQ	Adiponectin, C1Q and collagen domain containing. (245 aa)
	FRS2	Fibroblast growth factor receptor substrate 2. (508 aa)
	APLN	Apelin. (76 aa)
	PPARGC1A	PPARG coactivator 1 alpha. (834 aa)
	ENSAPLP00000029724	Uncharacterized protein. (131 aa)
	ENSAPLP00000027962	Uncharacterized protein. (328 aa)
	NDRG4	NDRG family member 4. (597 aa)
	ID2	Inhibitor of DNA binding 2. (134 aa)
	GNA13	G protein subunit alpha 13. (377 aa)
	MYOCD	Myocardin. (1032 aa)
	MEF2D	Myocyte enhancer factor 2D. (571 aa)
	PDGFRB	Platelet derived growth factor receptor beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1093 aa)
	THBS1	Thrombospondin 1. (1178 aa)
	NPR3	Natriuretic peptide receptor 3. (527 aa)
	CTNNBIP1	Catenin beta interacting protein 1. (81 aa)

Your Current Organism:

Anas platyrhynchos

NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADIPOQ	APLN	ENSAPLP00000013340	ENSAPLP00000021793	Adiponectin, C1Q and collagen domain containing.	Apelin.	0.532
ADIPOQ	IL10	ENSAPLP00000013340	ENSAPLP00000015242	Adiponectin, C1Q and collagen domain containing.	Interleukin 10.	0.534
ADIPOQ	IL6	ENSAPLP00000013340	ENSAPLP00000020478	Adiponectin, C1Q and collagen domain containing.	Uncharacterized protein.	0.760
ADIPOQ	PPARGC1A	ENSAPLP00000013340	ENSAPLP00000031219	Adiponectin, C1Q and collagen domain containing.	PPARG coactivator 1 alpha.	0.535
APLN	ADIPOQ	ENSAPLP00000021793	ENSAPLP00000013340	Apelin.	Adiponectin, C1Q and collagen domain containing.	0.532
CALCRL	VIP	ENSAPLP00000003027	ENSAPLP00000006328	Calcitonin receptor like receptor; Belongs to the G-protein coupled receptor 2 family.	Vasoactive intestinal peptide.	0.474
CTNNB1	CTNNBIP1	ENSAPLP00000013346	ENSAPLP00000021820	Catenin beta 1.	Catenin beta interacting protein 1.	0.999
CTNNB1	GJA1	ENSAPLP00000013346	ENSAPLP00000000131	Catenin beta 1.	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.	0.575
CTNNB1	IL6	ENSAPLP00000013346	ENSAPLP00000020478	Catenin beta 1.	Uncharacterized protein.	0.426
CTNNB1	MEF2D	ENSAPLP00000013346	ENSAPLP00000022350	Catenin beta 1.	Myocyte enhancer factor 2D.	0.465
CTNNB1	PIK3CA	ENSAPLP00000013346	ENSAPLP00000012758	Catenin beta 1.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.489
CTNNBIP1	CTNNB1	ENSAPLP00000021820	ENSAPLP00000013346	Catenin beta interacting protein 1.	Catenin beta 1.	0.999
CX3CL1	IL10	ENSAPLP00000012081	ENSAPLP00000015242	SCY domain-containing protein.	Interleukin 10.	0.488
CX3CL1	IL6	ENSAPLP00000012081	ENSAPLP00000020478	SCY domain-containing protein.	Uncharacterized protein.	0.491
EDN1	IL6	ENSAPLP00000016469	ENSAPLP00000020478	Endothelin 1.	Uncharacterized protein.	0.477
EDN1	THBS1	ENSAPLP00000016469	ENSAPLP00000022073	Endothelin 1.	Thrombospondin 1.	0.497
EREG	PDGFRB	ENSAPLP00000012792	ENSAPLP00000022197	Epiregulin.	Platelet derived growth factor receptor beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.654
EREG	PIK3CA	ENSAPLP00000012792	ENSAPLP00000012758	Epiregulin.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.552
FRS2	PDGFRB	ENSAPLP00000013035	ENSAPLP00000022197	Fibroblast growth factor receptor substrate 2.	Platelet derived growth factor receptor beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.404
FRS2	PIK3CA	ENSAPLP00000013035	ENSAPLP00000012758	Fibroblast growth factor receptor substrate 2.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.547