STRINGSTRING
WNT3A WNT3A TP63 TP63 NKX2-5 NKX2-5 FGF7 FGF7 ITGB3 ITGB3 U3IBF2_ANAPP U3IBF2_ANAPP VEGFC VEGFC KDR KDR FLT4 FLT4 JCAD JCAD AR AR VIP VIP FGF1 FGF1 FGF2 FGF2 SMO SMO ADAM17 ADAM17 U3IJT1_ANAPP U3IJT1_ANAPP OSR1 OSR1 BMPR2 BMPR2 PIK3CD PIK3CD NRAS NRAS TGFBR1 TGFBR1 JAML JAML PROK2 PROK2 VASH2 VASH2 ENSAPLP00000031389 ENSAPLP00000031389 CYP7B1 CYP7B1 ITGA4 ITGA4 HRAS HRAS WDR48 WDR48 SOX9 SOX9 PKHD1 PKHD1 CLDN1 CLDN1 CTNNB1 CTNNB1 MYC MYC PDGFB PDGFB HTR2B HTR2B IL10 IL10 MDK MDK PROK1 PROK1 DLX6 DLX6 ENSAPLP00000016447 ENSAPLP00000016447 ENSAPLP00000016895 ENSAPLP00000016895 ST8SIA1 ST8SIA1 NME2 NME2 PDX1 PDX1 VEGFA VEGFA STXBP4 STXBP4 MAP2K5 MAP2K5 ENSAPLP00000020125 ENSAPLP00000020125 IGF2 IGF2 ENSAPLP00000020693 ENSAPLP00000020693 ENSAPLP00000020991 ENSAPLP00000020991 APLNR APLNR CDC42 CDC42 APLN APLN MED1 MED1 ENSAPLP00000022040 ENSAPLP00000022040 ESRP2 ESRP2 ENSAPLP00000022297 ENSAPLP00000022297 OSR2 OSR2 MST1 MST1 NRARP NRARP DLX5 DLX5 F3 F3 APELA APELA PGF PGF BMP6 BMP6 NR4A1 NR4A1 SP1 SP1 VEGFD VEGFD ACVRL1 ACVRL1 SIRT6 SIRT6 ENSAPLP00000029368 ENSAPLP00000029368 ENSAPLP00000029593 ENSAPLP00000029593 XBP1 XBP1 NOG NOG FZD7 FZD7 SCG2 SCG2 FGFBP1 FGFBP1 EPGN EPGN TNFAIP3 TNFAIP3 HMGB2 HMGB2 CAV2 CAV2 SIRT1 SIRT1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
NKX2-5NK2 homeobox 5. (295 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (1055 aa)
U3IBF2_ANAPPMediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (596 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (418 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1345 aa)
FLT4Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1373 aa)
JCADJunctional cadherin 5 associated. (1332 aa)
ARAndrogen receptor. (385 aa)
VIPVasoactive intestinal peptide. (200 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (105 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (620 aa)
ADAM17ADAM metallopeptidase domain 17. (836 aa)
U3IJT1_ANAPPProtein kinase domain-containing protein. (313 aa)
OSR1Odd-skipped related transcription factor 1. (260 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1000 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1046 aa)
NRASUncharacterized protein. (189 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
JAMLIg-like domain-containing protein. (259 aa)
PROK2Prokineticin 2. (132 aa)
VASH2Vasohibin 2. (275 aa)
ENSAPLP00000031389WD_REPEATS_REGION domain-containing protein. (1265 aa)
CYP7B1Cytochrome P450 family 7 subfamily B member 1; Belongs to the cytochrome P450 family. (504 aa)
ITGA4Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (998 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
WDR48WD repeat domain 48. (678 aa)
SOX9SRY-box transcription factor 9. (489 aa)
PKHD1PKHD1 ciliary IPT domain containing fibrocystin/polyductin. (3633 aa)
CLDN1Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa)
CTNNB1Catenin beta 1. (781 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (418 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (251 aa)
HTR2B5-hydroxytryptamine receptor 2B. (463 aa)
IL10Interleukin 10. (177 aa)
MDKMidkine. (142 aa)
PROK1Prokineticin 1. (125 aa)
DLX6Distal-less homeobox 6. (267 aa)
ENSAPLP00000016447Uncharacterized protein. (672 aa)
ENSAPLP00000016895Uncharacterized protein. (72 aa)
ST8SIA1ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1; Belongs to the glycosyltransferase 29 family. (342 aa)
NME2Nucleoside diphosphate kinase. (153 aa)
PDX1Homeobox domain-containing protein. (264 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (488 aa)
STXBP4Syntaxin binding protein 4. (733 aa)
MAP2K5Mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily. (471 aa)
ENSAPLP00000020125GRANULINS domain-containing protein. (185 aa)
IGF2Insulin like growth factor 2. (224 aa)
ENSAPLP00000020693Raptor_N domain-containing protein. (91 aa)
ENSAPLP00000020991Raptor_N domain-containing protein. (91 aa)
APLNRApelin receptor; Belongs to the G-protein coupled receptor 1 family. (399 aa)
CDC42Cell division cycle 42. (282 aa)
APLNApelin. (76 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1474 aa)
ENSAPLP00000022040G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (356 aa)
ESRP2Epithelial splicing regulatory protein 2. (728 aa)
ENSAPLP00000022297G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (344 aa)
OSR2Odd-skipped related transciption factor 2. (323 aa)
MST1Macrophage stimulating 1. (903 aa)
NRARPNOTCH regulated ankyrin repeat protein. (114 aa)
DLX5Distal-less homeobox 5. (340 aa)
F3Coagulation factor III, tissue factor. (296 aa)
APELAUncharacterized protein. (54 aa)
PGFPlacental growth factor; Belongs to the PDGF/VEGF growth factor family. (279 aa)
BMP6Bone morphogenetic protein 6. (453 aa)
NR4A1Nuclear receptor subfamily 4 group A member 1. (586 aa)
SP1Sp1 transcription factor. (683 aa)
VEGFDVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (353 aa)
ACVRL1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (179 aa)
SIRT6Sirtuin 6. (203 aa)
ENSAPLP00000029368Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (139 aa)
ENSAPLP00000029593EF-hand domain-containing protein. (396 aa)
XBP1X-box binding protein 1. (313 aa)
NOGNoggin; Belongs to the noggin family. (223 aa)
FZD7Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (573 aa)
SCG2Secretogranin II. (660 aa)
FGFBP1Fibroblast growth factor binding protein 1. (211 aa)
EPGNEpithelial mitogen. (151 aa)
TNFAIP3TNF alpha induced protein 3. (870 aa)
HMGB2High mobility group box 2. (207 aa)
CAV2Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (161 aa)
SIRT1Sirtuin 1. (777 aa)
Your Current Organism:
Anas platyrhynchos
NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard
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