(66 nodes) Negative regulation of inflammatory response network (Anas platyrhynchos)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	RABGEF1	Uncharacterized protein. (532 aa)
	C5orf30	Chromosome 5 open reading frame 30. (436 aa)
	ENSAPLP00000032667	Uncharacterized protein. (268 aa)
	NLRC3	NLR family CARD domain containing 3. (1188 aa)
	ENSAPLP00000030610	Phospholipase A(2). (235 aa)
	MFHAS1	Malignant fibrous histiocytoma amplified sequence 1. (1009 aa)
	ENSAPLP00000029084	Uncharacterized protein; Belongs to the peptidase S1 family. (431 aa)
	MKRN2	Makorin ring finger protein 2. (604 aa)
	CYLD	CYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family. (970 aa)
	ENSAPLP00000026712	Uncharacterized protein. (156 aa)
	DUSP10	Dual specificity phosphatase 10. (443 aa)
	WFDC1	WAP four-disulfide core domain 1. (308 aa)
	ENSAPLP00000022390	Uncharacterized protein. (366 aa)
	VPS35	Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting. (830 aa)
	ENSAPLP00000020419	NR LBD domain-containing protein. (101 aa)
	ENSAPLP00000020125	GRANULINS domain-containing protein. (185 aa)
	MVK	Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily. (368 aa)
	LPCAT3	Lysophosphatidylcholine acyltransferase 3; Belongs to the membrane-bound acyltransferase family. (549 aa)
	PTGER4	Prostaglandin E receptor 4; Belongs to the G-protein coupled receptor 1 family. (474 aa)
	ASH1L	ASH1 like histone lysine methyltransferase. (3028 aa)
	ENSAPLP00000016977	Uncharacterized protein. (493 aa)
	FFAR4	G_PROTEIN_RECEP_F1_2 domain-containing protein. (352 aa)
	MDK	Midkine. (142 aa)
	U3J700_ANAPP	Phospholipase A(2). (161 aa)
	U3J6Z6_ANAPP	Uncharacterized protein. (427 aa)
	IL10	Interleukin 10. (177 aa)
	SYT11	Synaptotagmin 11. (430 aa)
	NLRX1	NLR family member X1. (973 aa)
	U3J1S1_ANAPP	Uncharacterized protein. (494 aa)
	ADIPOQ	Adiponectin, C1Q and collagen domain containing. (245 aa)
	NR1H4	Nuclear receptor subfamily 1 group H member 4. (439 aa)
	GPER1	G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (357 aa)
	CX3CL1	SCY domain-containing protein. (481 aa)
	SOCS3	Suppressor of cytokine signaling 3. (209 aa)
	GHSR	Growth hormone secretagogue receptor; Belongs to the G-protein coupled receptor 1 family. (352 aa)
	U3IWG8_ANAPP	Ig-like domain-containing protein. (308 aa)
	NT5E	5'-nucleotidase ecto; Belongs to the 5'-nucleotidase family. (570 aa)
	PPARA	Peroxisome proliferator activated receptor alpha. (447 aa)
	METRNL	Meteorin like, glial cell differentiation regulator. (292 aa)
	LRFN5	Leucine rich repeat and fibronectin type III domain containing 5. (776 aa)
	U3IRD8_ANAPP	Uncharacterized protein. (934 aa)
	GATA3	GATA binding protein 3. (712 aa)
	PSMB4	Proteasome subunit beta; Belongs to the peptidase T1B family. (255 aa)
	PTPN2	Tyrosine-protein phosphatase non-receptor type. (432 aa)
	IL12B	Interleukin-12 subunit beta; Belongs to the type I cytokine receptor family. Type 3 subfamily. (315 aa)
	PPARG	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (450 aa)
	U3IMS8_ANAPP	Uncharacterized protein; Belongs to the peptidase C19 family. (807 aa)
	AOAH	Acyloxyacyl hydrolase. (614 aa)
	RB1	RB transcriptional corepressor 1. (855 aa)
	TNFAIP6	TNF alpha induced protein 6. (285 aa)
	CCN3	Cellular communication network factor 3. (444 aa)
	OTULIN	OTU deubiquitinase with linear linkage specificity. (402 aa)
	SELENOS	Uncharacterized protein. (187 aa)
	NR1D2	Nuclear receptor subfamily 1 group D member 2. (623 aa)
	ACOD1	Aconitate decarboxylase 1. (383 aa)
	NDFIP1	Nedd4 family interacting protein 1. (252 aa)
	FNDC4	Fibronectin type III domain containing 4. (216 aa)
	GHRL	Ghrelin and obestatin prepropeptide. (116 aa)
	HGF	Uncharacterized protein. (183 aa)
	IL20RB	Interleukin 20 receptor subunit beta. (312 aa)
	C1QTNF12	C1q and TNF related 12. (320 aa)
	CST7	Cystatin F. (156 aa)
	SMPDL3B	Sphingomyelin phosphodiesterase acid like 3B. (593 aa)
	TNFAIP3	TNF alpha induced protein 3. (870 aa)
	SOCS5	Suppressor of cytokine signaling 5. (536 aa)
	GPR17	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (344 aa)

Your Current Organism:

Anas platyrhynchos

NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACOD1	ENSAPLP00000016977	ENSAPLP00000005141	ENSAPLP00000016977	Aconitate decarboxylase 1.	Uncharacterized protein.	0.902
ADIPOQ	GHRL	ENSAPLP00000013340	ENSAPLP00000003276	Adiponectin, C1Q and collagen domain containing.	Ghrelin and obestatin prepropeptide.	0.687
ADIPOQ	IL10	ENSAPLP00000013340	ENSAPLP00000015242	Adiponectin, C1Q and collagen domain containing.	Interleukin 10.	0.534
ADIPOQ	PPARA	ENSAPLP00000013340	ENSAPLP00000010405	Adiponectin, C1Q and collagen domain containing.	Peroxisome proliferator activated receptor alpha.	0.706
ADIPOQ	PPARG	ENSAPLP00000013340	ENSAPLP00000008758	Adiponectin, C1Q and collagen domain containing.	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]	0.816
CX3CL1	ENSAPLP00000022390	ENSAPLP00000012081	ENSAPLP00000022390	SCY domain-containing protein.	Uncharacterized protein.	0.465
CX3CL1	ENSAPLP00000032667	ENSAPLP00000012081	ENSAPLP00000032667	SCY domain-containing protein.	Uncharacterized protein.	0.609
CX3CL1	IL10	ENSAPLP00000012081	ENSAPLP00000015242	SCY domain-containing protein.	Interleukin 10.	0.488
CYLD	OTULIN	ENSAPLP00000027424	ENSAPLP00000005984	CYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family.	OTU deubiquitinase with linear linkage specificity.	0.709
CYLD	TNFAIP3	ENSAPLP00000027424	ENSAPLP00000001811	CYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family.	TNF alpha induced protein 3.	0.559
CYLD	U3IMS8_ANAPP	ENSAPLP00000027424	ENSAPLP00000008551	CYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family.	Uncharacterized protein; Belongs to the peptidase C19 family.	0.903
CYLD	U3J6Z6_ANAPP	ENSAPLP00000027424	ENSAPLP00000015273	CYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family.	Uncharacterized protein.	0.914
ENSAPLP00000016977	ACOD1	ENSAPLP00000016977	ENSAPLP00000005141	Uncharacterized protein.	Aconitate decarboxylase 1.	0.902
ENSAPLP00000020419	NR1D2	ENSAPLP00000020419	ENSAPLP00000005377	NR LBD domain-containing protein.	Nuclear receptor subfamily 1 group D member 2.	0.465
ENSAPLP00000022390	CX3CL1	ENSAPLP00000022390	ENSAPLP00000012081	Uncharacterized protein.	SCY domain-containing protein.	0.465
ENSAPLP00000026712	HGF	ENSAPLP00000026712	ENSAPLP00000002991	Uncharacterized protein.	Uncharacterized protein.	0.900
ENSAPLP00000032667	CX3CL1	ENSAPLP00000032667	ENSAPLP00000012081	Uncharacterized protein.	SCY domain-containing protein.	0.609
GATA3	IL10	ENSAPLP00000009770	ENSAPLP00000015242	GATA binding protein 3.	Interleukin 10.	0.697
GHRL	ADIPOQ	ENSAPLP00000003276	ENSAPLP00000013340	Ghrelin and obestatin prepropeptide.	Adiponectin, C1Q and collagen domain containing.	0.687
GHRL	GHSR	ENSAPLP00000003276	ENSAPLP00000011813	Ghrelin and obestatin prepropeptide.	Growth hormone secretagogue receptor; Belongs to the G-protein coupled receptor 1 family.	0.999