(89 nodes) Leukocyte migration network (Anas platyrhynchos)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ANO6	Anoctamin. (826 aa)
	IL16	Pro-interleukin-16; Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4. (1343 aa)
	JAML	Ig-like domain-containing protein. (259 aa)
	CYP7B1	Cytochrome P450 family 7 subfamily B member 1; Belongs to the cytochrome P450 family. (504 aa)
	TGFB2	Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
	ITGA4	Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (998 aa)
	GBF1	SEC7 domain-containing protein. (1781 aa)
	CX3CL1	SCY domain-containing protein. (481 aa)
	IL17RA	Interleukin 17 receptor A. (850 aa)
	U3IYY5_ANAPP	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (480 aa)
	CXCL8-3	Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (103 aa)
	U3IZ98_ANAPP	Uncharacterized protein; Belongs to the DOCK family. (1532 aa)
	PTPRO	Uncharacterized protein. (304 aa)
	U3J0Z8_ANAPP	Uncharacterized protein. (493 aa)
	ADD2	Adducin 2. (649 aa)
	GAS6	Growth arrest specific 6. (724 aa)
	PDGFB	Platelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (251 aa)
	PIKFYVE	Phosphoinositide kinase, FYVE-type zinc finger containing. (2091 aa)
	U3J4V3_ANAPP	Homeobox domain-containing protein. (195 aa)
	ITGA6	Integrin subunit alpha 6; Belongs to the integrin alpha chain family. (1082 aa)
	MDK	Midkine. (142 aa)
	TAFA3	TAFA chemokine like family member 3. (135 aa)
	CCL19	C-C motif chemokine. (106 aa)
	CD99L2	CD99 molecule like 2. (127 aa)
	ITGA3	Uncharacterized protein. (72 aa)
	CD34	CD34 molecule. (368 aa)
	ENSAPLP00000017273	SCY domain-containing protein. (182 aa)
	CCL5	C-C motif chemokine. (90 aa)
	EDNRB	Endothelin receptor type B; Belongs to the G-protein coupled receptor 1 family. (469 aa)
	ENSAPLP00000018130	Uncharacterized protein. (84 aa)
	ENSAPLP00000018177	C-C motif chemokine. (134 aa)
	CCR6	C-C motif chemokine receptor 6; Belongs to the G-protein coupled receptor 1 family. (364 aa)
	ARHGEF5	Uncharacterized protein. (1542 aa)
	EDN2	Endothelin 2. (181 aa)
	MADCAM1	Uncharacterized protein. (556 aa)
	ENSAPLP00000019517	Uncharacterized protein. (293 aa)
	JAM2	Junctional adhesion molecule 2. (377 aa)
	ENSAPLP00000019963	G_PROTEIN_RECEP_F1_2 domain-containing protein. (436 aa)
	CSF3R	Colony stimulating factor 3 receptor. (950 aa)
	ENSAPLP00000020935	Uncharacterized protein. (79 aa)
	CDC42	Cell division cycle 42. (282 aa)
	DOCK8	DUF3398 domain-containing protein. (503 aa)
	RABGEF1	Uncharacterized protein. (532 aa)
	IRAK4	Interleukin 1 receptor associated kinase 4. (541 aa)
	ENSAPLP00000023136	Uncharacterized protein. (387 aa)
	ROR2	Receptor tyrosine kinase like orphan receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (942 aa)
	MSN	Moesin. (615 aa)
	ENSAPLP00000026014	SCY domain-containing protein. (97 aa)
	BSG	Basigin (Ok blood group). (377 aa)
	TAFA4	TAFA chemokine like family member 4. (200 aa)
	IL-17	Uncharacterized protein. (191 aa)
	ENSAPLP00000027061	SCY domain-containing protein. (98 aa)
	CXADR	Uncharacterized protein. (424 aa)
	ANXA1	Annexin. (341 aa)
	ENSAPLP00000029374	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (422 aa)
	LGALS3	Galectin. (335 aa)
	JAM3	Junctional adhesion molecule 3. (299 aa)
	ENSAPLP00000030042	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (459 aa)
	ENSAPLP00000030823	C-C motif chemokine. (170 aa)
	ENSAPLP00000031423	Uncharacterized protein. (703 aa)
	GOLPH3	Golgi phosphoprotein 3. (295 aa)
	CCL20	C-C motif chemokine. (98 aa)
	ROCK1	Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1384 aa)
	PAFAH1B1	Lissencephaly-1 homolog; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. May be required for proliferation of neuronal precursors and neuronal migration; Belongs to the WD repeat LIS1/nudF family. (410 aa)
	ASB2	Ankyrin repeat and SOCS box containing 2. (679 aa)
	CXCR5	C-X-C motif chemokine receptor 5; Belongs to the G-protein coupled receptor 1 family. (371 aa)
	NEDD9	Neural precursor cell expressed, developmentally down-regulated 9. (823 aa)
	GPR183	G protein-coupled receptor 183; Belongs to the G-protein coupled receptor 1 family. (368 aa)
	SCG2	Secretogranin II. (660 aa)
	U3I3L9_ANAPP	ZP domain-containing protein. (423 aa)
	MCOLN2	Mucolipin 2. (499 aa)
	SYK	Spleen associated tyrosine kinase. (636 aa)
	CXCL8-2	Interleukin-8; Belongs to the intercrine alpha (chemokine CxC) family. (105 aa)
	KIT	Mast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (964 aa)
	PODXL2	Podocalyxin like 2. (641 aa)
	TNFSF11	TNF superfamily member 11; Belongs to the tumor necrosis factor family. (322 aa)
	U3IE35_ANAPP	Uncharacterized protein. (608 aa)
	AIMP1	Aminoacyl tRNA synthetase complex interacting multifunctional protein 1. (309 aa)
	SLC37A4	Solute carrier family 37 member 4. (362 aa)
	CRKL	CRK like proto-oncogene, adaptor protein. (301 aa)
	NUP85	Nuclear pore complex protein Nup85; Functions as a component of the nuclear pore complex (NPC). (651 aa)
	DBH	Dopamine beta-hydroxylase. (630 aa)
	TRPM2	Nudix hydrolase domain-containing protein. (1508 aa)
	CCR7	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. (374 aa)
	SPNS2	Sphingolipid transporter 2. (512 aa)
	ITGA9	Integrin subunit alpha 9; Belongs to the integrin alpha chain family. (1027 aa)
	GATA3	GATA binding protein 3. (712 aa)
	SRP54	Signal recognition particle 54 kDa protein; Binds to the signal sequence of presecretory protein when they emerge from the ribosomes and transfers them to TRAM (translocating chain-associating membrane protein). Belongs to the GTP-binding SRP family. SRP54 subfamily. (504 aa)
	CRTAM	Cytotoxic and regulatory T cell molecule. (477 aa)

Your Current Organism:

Anas platyrhynchos

NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADD2	MSN	ENSAPLP00000013444	ENSAPLP00000025338	Adducin 2.	Moesin.	0.430
ANXA1	LGALS3	ENSAPLP00000029030	ENSAPLP00000029583	Annexin.	Galectin.	0.583
ARHGEF5	CDC42	ENSAPLP00000018570	ENSAPLP00000021122	Uncharacterized protein.	Cell division cycle 42.	0.504
ARHGEF5	ROCK1	ENSAPLP00000018570	ENSAPLP00000032159	Uncharacterized protein.	Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity.	0.608
CCL19	CCL20	ENSAPLP00000016446	ENSAPLP00000031962	C-C motif chemokine.	C-C motif chemokine.	0.788
CCL19	CCL5	ENSAPLP00000016446	ENSAPLP00000017309	C-C motif chemokine.	C-C motif chemokine.	0.940
CCL19	CCR6	ENSAPLP00000016446	ENSAPLP00000018429	C-C motif chemokine.	C-C motif chemokine receptor 6; Belongs to the G-protein coupled receptor 1 family.	0.708
CCL19	CCR7	ENSAPLP00000016446	ENSAPLP00000007659	C-C motif chemokine.	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	0.979
CCL19	CX3CL1	ENSAPLP00000016446	ENSAPLP00000012081	C-C motif chemokine.	SCY domain-containing protein.	0.642
CCL19	CXCL8-2	ENSAPLP00000016446	ENSAPLP00000003181	C-C motif chemokine.	Interleukin-8; Belongs to the intercrine alpha (chemokine CxC) family.	0.625
CCL19	CXCL8-3	ENSAPLP00000016446	ENSAPLP00000012465	C-C motif chemokine.	Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family.	0.491
CCL19	CXCR5	ENSAPLP00000016446	ENSAPLP00000000175	C-C motif chemokine.	C-X-C motif chemokine receptor 5; Belongs to the G-protein coupled receptor 1 family.	0.736
CCL19	ENSAPLP00000026014	ENSAPLP00000016446	ENSAPLP00000026014	C-C motif chemokine.	SCY domain-containing protein.	0.677
CCL19	ENSAPLP00000029374	ENSAPLP00000016446	ENSAPLP00000029374	C-C motif chemokine.	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	0.471
CCL19	ENSAPLP00000030823	ENSAPLP00000016446	ENSAPLP00000030823	C-C motif chemokine.	C-C motif chemokine.	0.653
CCL20	CCL19	ENSAPLP00000031962	ENSAPLP00000016446	C-C motif chemokine.	C-C motif chemokine.	0.788
CCL20	CCL5	ENSAPLP00000031962	ENSAPLP00000017309	C-C motif chemokine.	C-C motif chemokine.	0.812
CCL20	CCR6	ENSAPLP00000031962	ENSAPLP00000018429	C-C motif chemokine.	C-C motif chemokine receptor 6; Belongs to the G-protein coupled receptor 1 family.	0.999
CCL20	CCR7	ENSAPLP00000031962	ENSAPLP00000007659	C-C motif chemokine.	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	0.826
CCL20	CX3CL1	ENSAPLP00000031962	ENSAPLP00000012081	C-C motif chemokine.	SCY domain-containing protein.	0.677