(119 nodes) Regulation of chemotaxis network (Anas platyrhynchos)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SEMA4A	Semaphorin 4A; Belongs to the semaphorin family. (701 aa)
	FGF18	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (276 aa)
	MET	MET proto-oncogene, receptor tyrosine kinase. (1382 aa)
	IL16	Pro-interleukin-16; Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4. (1343 aa)
	NELL2	Neural EGFL like 2. (742 aa)
	STK39	Serine/threonine kinase 39. (480 aa)
	MSTN	Myostatin. (375 aa)
	CXCL8-3	Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (103 aa)
	MYCBP2	MYC binding protein 2. (4649 aa)
	CSF1R	Colony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (894 aa)
	RIPOR2	PL48 domain-containing protein. (1097 aa)
	MOSPD2	Motile sperm domain containing 2. (517 aa)
	ADAM10	ADAM metallopeptidase domain 10. (711 aa)
	GAS6	Growth arrest specific 6. (724 aa)
	PDGFB	Platelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (251 aa)
	SLC8B1	Na_Ca_ex domain-containing protein; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (190 aa)
	NBL1	Neuroblastoma suppressor of tumorigenicity 1. (177 aa)
	PADI2	Peptidyl arginine deiminase 2. (664 aa)
	CXCL12	SCY domain-containing protein; Belongs to the intercrine alpha (chemokine CxC) family. (165 aa)
	MDK	Midkine. (142 aa)
	CCL19	C-C motif chemokine. (106 aa)
	WNT3	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (109 aa)
	ENSAPLP00000017273	SCY domain-containing protein. (182 aa)
	CCL5	C-C motif chemokine. (90 aa)
	ENSAPLP00000017749	Uncharacterized protein. (120 aa)
	ENSAPLP00000017767	G_PROTEIN_RECEP_F1_2 domain-containing protein. (311 aa)
	FGF4	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
	SEMA5A	Semaphorin 5A. (1076 aa)
	SEMA4C	Semaphorin 4C; Belongs to the semaphorin family. (820 aa)
	ENSAPLP00000018135	Uncharacterized protein. (74 aa)
	ENSAPLP00000018177	C-C motif chemokine. (134 aa)
	CCR6	C-C motif chemokine receptor 6; Belongs to the G-protein coupled receptor 1 family. (364 aa)
	ENSAPLP00000018518	Uncharacterized protein. (177 aa)
	ANGPT2	Angiopoietin 2. (495 aa)
	VEGFC	Vascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (418 aa)
	MPP1	Membrane palmitoylated protein 1; Belongs to the MAGUK family. (599 aa)
	U3ICH8_ANAPP	Uncharacterized protein; Belongs to the parvalbumin family. (107 aa)
	CXCL14	C-X-C motif chemokine ligand 14. (98 aa)
	EDN2	Endothelin 2. (181 aa)
	SLIT2	Slit guidance ligand 2. (1528 aa)
	ENSAPLP00000018750	Uncharacterized protein. (239 aa)
	P2RX4	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (397 aa)
	MMP28	Matrix metallopeptidase 28. (501 aa)
	VEGFA	Vascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (488 aa)
	SEMA3E	Semaphorin 3E; Belongs to the semaphorin family. (809 aa)
	FAM49B	Family with sequence similarity 49 member B. (398 aa)
	ENSAPLP00000021214	Sema domain-containing protein; Belongs to the semaphorin family. (437 aa)
	THBS1	Thrombospondin 1. (1178 aa)
	SEMA3D	Semaphorin 3D; Belongs to the semaphorin family. (761 aa)
	ENSAPLP00000023136	Uncharacterized protein. (387 aa)
	YTHDF1	YTH N6-methyladenosine RNA binding protein 1. (674 aa)
	MST1	Macrophage stimulating 1. (903 aa)
	ENSAPLP00000024180	Uncharacterized protein. (153 aa)
	SEMA6B	Semaphorin 6B. (644 aa)
	GDF11	Growth differentiation factor 11. (320 aa)
	DNM1L	Dynamin 1 like; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (750 aa)
	SEMA3F	Semaphorin 3F; Belongs to the semaphorin family. (718 aa)
	PGF	Placental growth factor; Belongs to the PDGF/VEGF growth factor family. (279 aa)
	C1QBP	Complement C1q binding protein. (162 aa)
	DSCAM	Uncharacterized protein. (1868 aa)
	BST1	Bone marrow stromal cell antigen 1. (315 aa)
	ENSAPLP00000025972	PH domain-containing protein. (96 aa)
	ENSAPLP00000026014	SCY domain-containing protein. (97 aa)
	SEMA5B	Semaphorin 5B. (1031 aa)
	EFNB2	Ephrin B2; Belongs to the ephrin family. (333 aa)
	ENSAPLP00000027031	Uncharacterized protein. (465 aa)
	VAX1	Ventral anterior homeobox 1. (304 aa)
	VEGFD	Vascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (353 aa)
	ENSAPLP00000028822	Anaphylatoxin-like domain-containing protein. (109 aa)
	SEMA4D	Semaphorin 4D; Belongs to the semaphorin family. (854 aa)
	ENSAPLP00000029805	SH2 domain-containing protein. (409 aa)
	JAM3	Junctional adhesion molecule 3. (299 aa)
	ENSAPLP00000030153	annotation not available (1868 aa)
	SEMA4G	Semaphorin 4G; Belongs to the semaphorin family. (718 aa)
	SEMA4B	Semaphorin 4B; Belongs to the semaphorin family. (718 aa)
	ENSAPLP00000030600	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (279 aa)
	SEMA6A	Semaphorin 6A; Belongs to the semaphorin family. (1044 aa)
	SEMA6D	Semaphorin 6D; Belongs to the semaphorin family. (1232 aa)
	CSF1	Uncharacterized protein. (472 aa)
	SEMA3A	Semaphorin 3A; Belongs to the semaphorin family. (932 aa)
	ENSAPLP00000031678	Focal_AT domain-containing protein. (116 aa)
	CREB3	Uncharacterized protein. (387 aa)
	CD74	CD74 molecule. (300 aa)
	SLIT1	Slit guidance ligand 1. (1541 aa)
	SEMA7A	Semaphorin 7A (John Milton Hagen blood group); Belongs to the semaphorin family. (798 aa)
	ANO6	Anoctamin. (826 aa)
	IL12A	Interleukin-12 subunit alpha; Belongs to the IL-6 superfamily. (214 aa)
	LYN	Tyrosine-protein kinase. (535 aa)
	CCN3	Cellular communication network factor 3. (444 aa)
	KDR	Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1345 aa)
	TNFAIP6	TNF alpha induced protein 6. (285 aa)
	C5	Complement C5. (880 aa)
	ADAM17	ADAM metallopeptidase domain 17. (836 aa)
	LGMN	Legumain. (431 aa)
	CCR7	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. (374 aa)
	BMPR2	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1000 aa)
	TBR1	Uncharacterized protein. (231 aa)
	NELL1	Neural EGFL like 1. (808 aa)
	STAP1	Signal transducing adaptor family member 1. (316 aa)
	ATOH7	Atonal bHLH transcription factor 7. (151 aa)
	U3HZF4_ANAPP	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (377 aa)
	U3HZZ8_ANAPP	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (350 aa)
	USP14	Ubiquitin carboxyl-terminal hydrolase. (495 aa)
	NEDD9	Neural precursor cell expressed, developmentally down-regulated 9. (823 aa)
	GPR18	G protein-coupled receptor 18; Belongs to the G-protein coupled receptor 1 family. (321 aa)
	GPR183	G protein-coupled receptor 183; Belongs to the G-protein coupled receptor 1 family. (368 aa)
	SCG2	Secretogranin II. (660 aa)
	TIRAP	TIR domain containing adaptor protein. (219 aa)
	C3AR1	Complement C3a receptor 1; Belongs to the G-protein coupled receptor 1 family. (481 aa)
	RYK	Uncharacterized protein. (562 aa)
	U3I4D2_ANAPP	Uncharacterized protein; Belongs to the semaphorin family. (747 aa)
	CXCL8	Interleukin-8; Belongs to the intercrine alpha (chemokine CxC) family. (100 aa)
	CXCL8-2	Interleukin-8; Belongs to the intercrine alpha (chemokine CxC) family. (105 aa)
	U3I882_ANAPP	Protein kinase domain-containing protein. (355 aa)
	SEMA3C	Semaphorin 3C; Belongs to the semaphorin family. (751 aa)
	U3INT4_ANAPP	Uncharacterized protein; Belongs to the peptidase S9B family. (756 aa)
	U3IPQ3_ANAPP	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. (507 aa)
	PTPN2	Tyrosine-protein phosphatase non-receptor type. (432 aa)
	S100A14	S100 calcium binding protein A14; Belongs to the S-100 family. (120 aa)

Your Current Organism:

Anas platyrhynchos

NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADAM10	VEGFD	ENSAPLP00000013418	ENSAPLP00000028580	ADAM metallopeptidase domain 10.	Vascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family.	0.423
ANGPT2	CSF1R	ENSAPLP00000005273	ENSAPLP00000012815	Angiopoietin 2.	Colony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.734
ANGPT2	CXCL8-3	ENSAPLP00000005273	ENSAPLP00000012465	Angiopoietin 2.	Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family.	0.465
ANGPT2	KDR	ENSAPLP00000005273	ENSAPLP00000005293	Angiopoietin 2.	Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.890
ANGPT2	MET	ENSAPLP00000005273	ENSAPLP00000010756	Angiopoietin 2.	MET proto-oncogene, receptor tyrosine kinase.	0.679
ANGPT2	PDGFB	ENSAPLP00000005273	ENSAPLP00000013819	Angiopoietin 2.	Platelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family.	0.611
ANGPT2	PGF	ENSAPLP00000005273	ENSAPLP00000025068	Angiopoietin 2.	Placental growth factor; Belongs to the PDGF/VEGF growth factor family.	0.436
ANGPT2	THBS1	ENSAPLP00000005273	ENSAPLP00000022073	Angiopoietin 2.	Thrombospondin 1.	0.498
ANGPT2	VEGFC	ENSAPLP00000005273	ENSAPLP00000005042	Angiopoietin 2.	Vascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family.	0.623
ANGPT2	VEGFD	ENSAPLP00000005273	ENSAPLP00000028580	Angiopoietin 2.	Vascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family.	0.430
ATOH7	GDF11	ENSAPLP00000000142	ENSAPLP00000024532	Atonal bHLH transcription factor 7.	Growth differentiation factor 11.	0.551
BMPR2	GDF11	ENSAPLP00000007813	ENSAPLP00000024532	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Growth differentiation factor 11.	0.521
C3AR1	C5	ENSAPLP00000001400	ENSAPLP00000007205	Complement C3a receptor 1; Belongs to the G-protein coupled receptor 1 family.	Complement C5.	0.573
C3AR1	ENSAPLP00000028822	ENSAPLP00000001400	ENSAPLP00000028822	Complement C3a receptor 1; Belongs to the G-protein coupled receptor 1 family.	Anaphylatoxin-like domain-containing protein.	0.573
C5	C3AR1	ENSAPLP00000007205	ENSAPLP00000001400	Complement C5.	Complement C3a receptor 1; Belongs to the G-protein coupled receptor 1 family.	0.573
C5	ENSAPLP00000017767	ENSAPLP00000007205	ENSAPLP00000017767	Complement C5.	G_PROTEIN_RECEP_F1_2 domain-containing protein.	0.573
C5	ENSAPLP00000028822	ENSAPLP00000007205	ENSAPLP00000028822	Complement C5.	Anaphylatoxin-like domain-containing protein.	0.430
C5	U3HZZ8_ANAPP	ENSAPLP00000007205	ENSAPLP00000000568	Complement C5.	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	0.994
CCL19	CCL5	ENSAPLP00000016446	ENSAPLP00000017309	C-C motif chemokine.	C-C motif chemokine.	0.940
CCL19	CCR6	ENSAPLP00000016446	ENSAPLP00000018429	C-C motif chemokine.	C-C motif chemokine receptor 6; Belongs to the G-protein coupled receptor 1 family.	0.708