STRINGSTRING
CTNNB1 CTNNB1 CLIC2 CLIC2 NOG NOG U3I0R1_ANAPP U3I0R1_ANAPP GREM2 GREM2 SPPL3 SPPL3 CAV1 CAV1 U3I2I6_ANAPP U3I2I6_ANAPP PLN PLN TNKS TNKS STYX STYX EIF3D EIF3D HIP1R HIP1R CCPG1 CCPG1 CTHRC1 CTHRC1 NSD1 NSD1 GAS8 GAS8 HMGB2 HMGB2 BAG2 BAG2 TTBK1 TTBK1 SMAD4 SMAD4 U3I8G6_ANAPP U3I8G6_ANAPP LRRC6 LRRC6 PCSK9 PCSK9 ATP2A2 ATP2A2 U3IBK2_ANAPP U3IBK2_ANAPP TNFSF11 TNFSF11 TTC36 TTC36 SRI SRI MYOD1 MYOD1 EIF3E EIF3E BTAF1 BTAF1 PEX14 PEX14 CAPRIN2 CAPRIN2 RIPK2 RIPK2 ITGB1BP1 ITGB1BP1 CDT1 CDT1 LEF1 LEF1 DHRS7B DHRS7B U3IJ88_ANAPP U3IJ88_ANAPP SMO SMO RB1 RB1 GPSM1 GPSM1 TXN TXN APP APP DAB2 DAB2 REST REST BAMBI BAMBI SKI SKI LARP6 LARP6 TAF10 TAF10 TGFBR1 TGFBR1 STMN1 STMN1 GATA3 GATA3 PARP9 PARP9 GCG GCG EP300 EP300 CSNK1A1 CSNK1A1 PLK1 PLK1 TTBK2 TTBK2 NEK2 NEK2 MET MET UBASH3B UBASH3B KDM1A KDM1A ZMPSTE24 ZMPSTE24 ITGA4 ITGA4 ARHGAP28 ARHGAP28 EGF EGF GEMIN2 GEMIN2 TFIP11 TFIP11 LRRK2 LRRK2 GMNN GMNN RIPOR2 RIPOR2 DTNBP1 DTNBP1 ADIPOQ ADIPOQ RAN RAN ADD2 ADD2 HJURP HJURP U3J2D4_ANAPP U3J2D4_ANAPP PDGFB PDGFB PITX2 PITX2 ERCC4 ERCC4 PIN1 PIN1 PHLDA2 PHLDA2 MITD1 MITD1 GTF2B GTF2B IL10 IL10 WFIKKN2 WFIKKN2 LDLRAP1 LDLRAP1 ANKRD33B ANKRD33B AKTIP AKTIP IDE IDE EPB41L5 EPB41L5 LFNG LFNG ENSAPLP00000016691 ENSAPLP00000016691 ENSAPLP00000016714 ENSAPLP00000016714 FRMD7 FRMD7 CRMP1 CRMP1 ENSAPLP00000017681 ENSAPLP00000017681 TERT TERT NVL NVL ENSAPLP00000017898 ENSAPLP00000017898 PTK2 PTK2 NUCKS1 NUCKS1 PSEN1 PSEN1 ENSAPLP00000018112 ENSAPLP00000018112 ENSAPLP00000018138 ENSAPLP00000018138 ENSAPLP00000018149 ENSAPLP00000018149 POLDIP2 POLDIP2 WAPL WAPL RIPOR3 RIPOR3 ENSAPLP00000020032 ENSAPLP00000020032 ENSAPLP00000020107 ENSAPLP00000020107 ADNP ADNP ABL2 ABL2 DTX3L DTX3L ADD1 ADD1 EPHA4 EPHA4 CDC42 CDC42 DKK1 DKK1 ENSAPLP00000021461 ENSAPLP00000021461 CTNNBIP1 CTNNBIP1 ENSAPLP00000022008 ENSAPLP00000022008 ABL1 ABL1 LRPAP1 LRPAP1 ENSAPLP00000023040 ENSAPLP00000023040 NIBAN2 NIBAN2 TDG TDG WFIKKN1 WFIKKN1 PKD1 PKD1 MDFI MDFI MAP2 MAP2 PSME3IP1 PSME3IP1 RRP8 RRP8 DDX11 DDX11 ZBTB7A ZBTB7A MYOCD MYOCD DOT1L DOT1L FBXW7 FBXW7 ENSAPLP00000025377 ENSAPLP00000025377 ZNF618 ZNF618 ENSAPLP00000025759 ENSAPLP00000025759 DERL1 DERL1 MSX1 MSX1 PRKN PRKN ENSAPLP00000026067 ENSAPLP00000026067 MAPRE1 MAPRE1 DISC1 DISC1 TTBK2-2 TTBK2-2 ANKRD33 ANKRD33 HAND1 HAND1 NEUROD1 NEUROD1 ILRUN ILRUN PINX1 PINX1 TRAF6 TRAF6 RAPGEF2 RAPGEF2 ENSAPLP00000028132 ENSAPLP00000028132 EFHB EFHB ZNF462 ZNF462 HMGA2 HMGA2 TEX14 TEX14 CLDN5 CLDN5 ENSAPLP00000029814 ENSAPLP00000029814 CAPRIN2-2 CAPRIN2-2 RSF1 RSF1 ENSAPLP00000031176 ENSAPLP00000031176 ENSAPLP00000031209 ENSAPLP00000031209 ENSAPLP00000031212 ENSAPLP00000031212 FMR1 FMR1 ZC4H2 ZC4H2 MFNG MFNG PLXND1 PLXND1 ZFPM1 ZFPM1 CLN5 CLN5 ROCK1 ROCK1 LIF LIF C9orf72 C9orf72 RNF220 RNF220 BLK BLK ENSAPLP00000032903 ENSAPLP00000032903
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CTNNB1Catenin beta 1. (781 aa)
CLIC2Chloride intracellular channel protein; Belongs to the chloride channel CLIC family. (244 aa)
NOGNoggin; Belongs to the noggin family. (223 aa)
U3I0R1_ANAPPUncharacterized protein. (166 aa)
GREM2Gremlin 2, DAN family BMP antagonist. (381 aa)
SPPL3Signal peptide peptidase like 3. (380 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
U3I2I6_ANAPPProtein kinase domain-containing protein. (184 aa)
PLNCardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. (52 aa)
TNKSPoly [ADP-ribose] polymerase. (1143 aa)
STYXSerine/threonine/tyrosine interacting protein. (228 aa)
EIF3DEukaryotic translation initiation factor 3 subunit D. (396 aa)
HIP1RHuntingtin interacting protein 1 related. (1188 aa)
CCPG1Cell cycle progression 1. (776 aa)
CTHRC1Collagen triple helix repeat containing 1. (271 aa)
NSD1Nuclear receptor binding SET domain protein 1. (2293 aa)
GAS8Growth arrest specific 8. (395 aa)
HMGB2High mobility group box 2. (207 aa)
BAG2BCL2 associated athanogene 2. (225 aa)
TTBK1Tau tubulin kinase 1. (1348 aa)
SMAD4Mothers against decapentaplegic homolog. (551 aa)
U3I8G6_ANAPPHelicase ATP-binding domain-containing protein. (325 aa)
LRRC6Leucine rich repeat containing 6. (418 aa)
PCSK9Proprotein convertase subtilisin/kexin type 9; Belongs to the peptidase S8 family. (656 aa)
ATP2A2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1022 aa)
U3IBK2_ANAPPUncharacterized protein. (566 aa)
TNFSF11TNF superfamily member 11; Belongs to the tumor necrosis factor family. (322 aa)
TTC36Tetratricopeptide repeat domain 36. (188 aa)
SRISorcin. (198 aa)
MYOD1Myogenic factor. (297 aa)
EIF3EEukaryotic translation initiation factor 3 subunit E; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. (445 aa)
BTAF1B-TFIID TATA-box binding protein associated factor 1. (1879 aa)
PEX14Peroxisomal biogenesis factor 14. (260 aa)
CAPRIN2Caprin family member 2. (902 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (552 aa)
ITGB1BP1Integrin subunit beta 1 binding protein 1. (200 aa)
CDT1Chromatin licensing and DNA replication factor 1. (353 aa)
LEF1Uncharacterized protein. (415 aa)
DHRS7BDehydrogenase/reductase 7B; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (324 aa)
U3IJ88_ANAPPUncharacterized protein. (678 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (620 aa)
RB1RB transcriptional corepressor 1. (855 aa)
GPSM1G protein signaling modulator 1. (666 aa)
TXNThioredoxin; Belongs to the thioredoxin family. (105 aa)
APPAmyloid beta precursor protein. (717 aa)
DAB2DAB adaptor protein 2. (715 aa)
RESTRE1 silencing transcription factor. (944 aa)
BAMBIBMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (259 aa)
SKISKI proto-oncogene. (744 aa)
LARP6La ribonucleoprotein domain family member 6. (465 aa)
TAF10TATA-box binding protein associated factor 10. (175 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
STMN1Stathmin; Belongs to the stathmin family. (148 aa)
GATA3GATA binding protein 3. (712 aa)
PARP9Poly [ADP-ribose] polymerase. (819 aa)
GCGGlucagon. (206 aa)
EP300E1A binding protein p300. (2355 aa)
CSNK1A1Casein kinase 1 alpha 1; Belongs to the protein kinase superfamily. (336 aa)
PLK1Serine/threonine-protein kinase PLK. (596 aa)
TTBK2Tau tubulin kinase 2. (918 aa)
NEK2NIMA related kinase 2. (482 aa)
METMET proto-oncogene, receptor tyrosine kinase. (1382 aa)
UBASH3BUbiquitin associated and SH3 domain containing B. (650 aa)
KDM1ALysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (829 aa)
ZMPSTE24CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (465 aa)
ITGA4Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (998 aa)
ARHGAP28Rho GTPase activating protein 28. (677 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1182 aa)
GEMIN2Gem-associated protein 2; The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs; Belongs to the gemin-2 family. (263 aa)
TFIP11Tuftelin-interacting protein 11; Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events. Belongs to the TFP11/STIP family. (825 aa)
LRRK2Leucine rich repeat kinase 2. (2534 aa)
GMNNUncharacterized protein. (407 aa)
RIPOR2PL48 domain-containing protein. (1097 aa)
DTNBP1Dystrobrevin binding protein 1. (345 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (245 aa)
RANGTP-binding nuclear protein Ran; GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle. Belongs to the small GTPase superfamily. Ran family. (216 aa)
ADD2Adducin 2. (649 aa)
HJURPUncharacterized protein. (810 aa)
U3J2D4_ANAPPNucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily. (631 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (251 aa)
PITX2Homeobox protein. (334 aa)
ERCC4ERCC excision repair 4, endonuclease catalytic subunit. (903 aa)
PIN1Peptidyl-prolyl cis-trans isomerase. (149 aa)
PHLDA2Pleckstrin homology like domain family A member 2. (150 aa)
MITD1Microtubule interacting and trafficking domain containing 1. (250 aa)
GTF2BGeneral transcription factor IIB. (316 aa)
IL10Interleukin 10. (177 aa)
WFIKKN2WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2. (570 aa)
LDLRAP1Low density lipoprotein receptor adaptor protein 1. (301 aa)
ANKRD33BAnkyrin repeat domain 33B. (517 aa)
AKTIPAKT interacting protein. (293 aa)
IDEInsulin degrading enzyme; Belongs to the peptidase M16 family. (1049 aa)
EPB41L5Erythrocyte membrane protein band 4.1 like 5. (778 aa)
LFNGLFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase. (500 aa)
ENSAPLP00000016691Uncharacterized protein. (235 aa)
ENSAPLP00000016714FERM_N_2 domain-containing protein. (80 aa)
FRMD7FERM domain containing 7. (614 aa)
CRMP1Collapsin response mediator protein 1. (729 aa)
ENSAPLP00000017681Uncharacterized protein. (64 aa)
TERTTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. (1347 aa)
NVLNuclear VCP like. (861 aa)
ENSAPLP00000017898Uncharacterized protein. (463 aa)
PTK2Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1119 aa)
NUCKS1Nuclear casein kinase and cyclin dependent kinase substrate 1. (292 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (465 aa)
ENSAPLP00000018112Uncharacterized protein. (346 aa)
ENSAPLP00000018138Uncharacterized protein. (114 aa)
ENSAPLP00000018149Uncharacterized protein. (378 aa)
POLDIP2DNA polymerase delta interacting protein 2. (118 aa)
WAPLWAPL cohesin release factor. (1262 aa)
RIPOR3RIPOR family member 3. (949 aa)
ENSAPLP00000020032Uncharacterized protein; Belongs to the ATP:guanido phosphotransferase family. (431 aa)
ENSAPLP00000020107Uncharacterized protein. (58 aa)
ADNPActivity dependent neuroprotector homeobox. (1228 aa)
ABL2Tyrosine-protein kinase. (1135 aa)
DTX3LDeltex E3 ubiquitin ligase 3L. (741 aa)
ADD1Adducin 1. (857 aa)
EPHA4EPH receptor A4. (1030 aa)
CDC42Cell division cycle 42. (282 aa)
DKK1Dickkopf WNT signaling pathway inhibitor 1. (271 aa)
ENSAPLP00000021461Uncharacterized protein. (136 aa)
CTNNBIP1Catenin beta interacting protein 1. (81 aa)
ENSAPLP00000022008Helicase ATP-binding domain-containing protein. (158 aa)
ABL1ABL proto-oncogene 1, non-receptor tyrosine kinase. (610 aa)
LRPAP1LDL receptor related protein associated protein 1. (365 aa)
ENSAPLP00000023040Uncharacterized protein. (136 aa)
NIBAN2Niban apoptosis regulator 2. (962 aa)
TDGThymine DNA glycosylase. (296 aa)
WFIKKN1WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1. (575 aa)
PKD1PLAT domain-containing protein. (291 aa)
MDFIMyoD family inhibitor. (357 aa)
MAP2Microtubule-associated protein. (1879 aa)
PSME3IP1Family with sequence similarity 192 member A. (279 aa)
RRP8Uncharacterized protein. (716 aa)
DDX11HELICc2 domain-containing protein. (115 aa)
ZBTB7AZinc finger and BTB domain containing 7A. (661 aa)
MYOCDMyocardin. (1032 aa)
DOT1LHistone-lysine N-methyltransferase, H3 lysine-79 specific. (1754 aa)
FBXW7F-box and WD repeat domain containing 7. (754 aa)
ENSAPLP00000025377Uncharacterized protein. (638 aa)
ZNF618Zinc finger protein 618. (330 aa)
ENSAPLP00000025759IF rod domain-containing protein; Belongs to the intermediate filament family. (308 aa)
DERL1Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (339 aa)
MSX1Msh homeobox 1. (299 aa)
PRKNParkin RBR E3 ubiquitin protein ligase. (520 aa)
ENSAPLP00000026067Uncharacterized protein. (440 aa)
MAPRE1Microtubule associated protein RP/EB family member 1. (263 aa)
DISC1DISC1 scaffold protein. (888 aa)
TTBK2-2Protein kinase domain-containing protein. (71 aa)
ANKRD33Ankyrin repeat domain 33. (444 aa)
HAND1Heart and neural crest derivatives expressed 1. (202 aa)
NEUROD1Neurogenic differentiation factor. (359 aa)
ILRUNInflammation and lipid regulator with UBA-like and NBR1-like domains. (405 aa)
PINX1PIN2 (TERF1) interacting telomerase inhibitor 1. (358 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (545 aa)
RAPGEF2Rap guanine nucleotide exchange factor 2. (1657 aa)
ENSAPLP00000028132Transcription initiation factor IIF subunit alpha; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. Belongs to the TFIIF alpha subunit family. (393 aa)
EFHBUncharacterized protein. (177 aa)
ZNF462Zinc finger protein 462. (2459 aa)
HMGA2Uncharacterized protein. (202 aa)
TEX14Testis expressed 14, intercellular bridge forming factor. (1626 aa)
CLDN5Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (196 aa)
ENSAPLP00000029814Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily. (669 aa)
CAPRIN2-2C1q domain-containing protein. (115 aa)
RSF1Remodeling and spacing factor 1. (1354 aa)
ENSAPLP00000031176HELICc2 domain-containing protein. (271 aa)
ENSAPLP00000031209HTH La-type RNA-binding domain-containing protein. (417 aa)
ENSAPLP00000031212SH2 domain-containing protein. (71 aa)
FMR1Fragile X mental retardation 1. (565 aa)
ZC4H2Zinc finger C4H2-type containing. (224 aa)
MFNGMFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase. (420 aa)
PLXND1Plexin D1. (1951 aa)
ZFPM1Zinc finger protein, FOG family member 1. (1057 aa)
CLN5Uncharacterized protein. (234 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1384 aa)
LIFLIF interleukin 6 family cytokine. (257 aa)
C9orf72C9orf72-SMCR8 complex subunit. (481 aa)
RNF220Ring finger protein 220. (678 aa)
BLKTyrosine-protein kinase. (525 aa)
ENSAPLP00000032903HMG box domain-containing protein. (180 aa)
Your Current Organism:
Anas platyrhynchos
NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard
Server load: low (16%) [HD]