(34 nodes) Negative regulation of ERK1 and ERK2 cascade network (Anas platyrhynchos)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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textmining

co-expression

protein homology

Your Input:
	SPRY1	Sprouty RTK signaling antagonist 1. (320 aa)
	ENSAPLP00000032786	CCDC144C domain-containing protein. (240 aa)
	SPRY4	Sprouty RTK signaling antagonist 4. (299 aa)
	DUSP26	Dual specificity phosphatase 26; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (264 aa)
	SMAD4	Mothers against decapentaplegic homolog. (551 aa)
	FLCN	UDENN FLCN/SMCR8-type domain-containing protein. (579 aa)
	LYN	Tyrosine-protein kinase. (535 aa)
	ITGB1BP1	Integrin subunit beta 1 binding protein 1. (200 aa)
	PTPN1	Tyrosine-protein phosphatase non-receptor type. (436 aa)
	DAB2	DAB adaptor protein 2. (715 aa)
	PTPN2	Tyrosine-protein phosphatase non-receptor type. (432 aa)
	ERRFI1	ERBB receptor feedback inhibitor 1. (465 aa)
	SPRY2	Sprouty RTK signaling antagonist 2. (309 aa)
	ATF3	Activating transcription factor 3. (189 aa)
	EZR	Ezrin. (585 aa)
	SPRY3	Sprouty RTK signaling antagonist 3. (292 aa)
	WNK2	WNK lysine deficient protein kinase 2. (2275 aa)
	GPER1	G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (357 aa)
	ADIPOQ	Adiponectin, C1Q and collagen domain containing. (245 aa)
	TNIP3	TNFAIP3 interacting protein 3. (397 aa)
	PIN1	Peptidyl-prolyl cis-trans isomerase. (149 aa)
	PTPRR	Protein tyrosine phosphatase receptor type R. (658 aa)
	EMILIN1	Elastin microfibril interfacer 1. (559 aa)
	TIMP3	TIMP metallopeptidase inhibitor 3. (275 aa)
	SYNJ2BP-COX16	SYNJ2BP-COX16 readthrough. (179 aa)
	DUSP10	Dual specificity phosphatase 10. (443 aa)
	VRK3	Uncharacterized protein. (597 aa)
	TNIP1	TNFAIP3 interacting protein 1. (841 aa)
	ENSAPLP00000029056	Uncharacterized protein. (2204 aa)
	PSCA	Prostate stem cell antigen. (122 aa)
	DUSP4	Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (449 aa)
	SPRED1	Sprouty related EVH1 domain containing 1. (414 aa)
	C3orf33	Chromosome 3 open reading frame 33. (247 aa)
	LIF	LIF interleukin 6 family cytokine. (257 aa)

Your Current Organism:

Anas platyrhynchos

NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DUSP26	VRK3	ENSAPLP00000002500	ENSAPLP00000026335	Dual specificity phosphatase 26; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Uncharacterized protein.	0.541
LYN	PTPN1	ENSAPLP00000005775	ENSAPLP00000008223	Tyrosine-protein kinase.	Tyrosine-protein phosphatase non-receptor type.	0.666
LYN	PTPN2	ENSAPLP00000005775	ENSAPLP00000009354	Tyrosine-protein kinase.	Tyrosine-protein phosphatase non-receptor type.	0.425
PTPN1	LYN	ENSAPLP00000008223	ENSAPLP00000005775	Tyrosine-protein phosphatase non-receptor type.	Tyrosine-protein kinase.	0.666
PTPN2	LYN	ENSAPLP00000009354	ENSAPLP00000005775	Tyrosine-protein phosphatase non-receptor type.	Tyrosine-protein kinase.	0.425
SPRY1	SPRY2	ENSAPLP00000000713	ENSAPLP00000011341	Sprouty RTK signaling antagonist 1.	Sprouty RTK signaling antagonist 2.	0.572
SPRY1	SPRY3	ENSAPLP00000000713	ENSAPLP00000012268	Sprouty RTK signaling antagonist 1.	Sprouty RTK signaling antagonist 3.	0.471
SPRY1	SPRY4	ENSAPLP00000000713	ENSAPLP00000001081	Sprouty RTK signaling antagonist 1.	Sprouty RTK signaling antagonist 4.	0.613
SPRY2	SPRY1	ENSAPLP00000011341	ENSAPLP00000000713	Sprouty RTK signaling antagonist 2.	Sprouty RTK signaling antagonist 1.	0.572
SPRY3	SPRY1	ENSAPLP00000012268	ENSAPLP00000000713	Sprouty RTK signaling antagonist 3.	Sprouty RTK signaling antagonist 1.	0.471
SPRY4	SPRY1	ENSAPLP00000001081	ENSAPLP00000000713	Sprouty RTK signaling antagonist 4.	Sprouty RTK signaling antagonist 1.	0.613
VRK3	DUSP26	ENSAPLP00000026335	ENSAPLP00000002500	Uncharacterized protein.	Dual specificity phosphatase 26; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	0.541