(23 nodes) Cellular response to epidermal growth factor stimulus network (Anas platyrhynchos)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SYAP1	Synapse associated protein 1. (337 aa)
	EGFR	Receptor protein-tyrosine kinase. (1219 aa)
	U3IBF2_ANAPP	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (596 aa)
	GAREM1	GRB2 associated regulator of MAPK1 subtype 1. (848 aa)
	ENSAPLP00000032776	Uncharacterized protein. (222 aa)
	INPP5K	Inositol polyphosphate-5-phosphatase K. (355 aa)
	DAB2	DAB adaptor protein 2. (715 aa)
	ERRFI1	ERBB receptor feedback inhibitor 1. (465 aa)
	SOX9	SRY-box transcription factor 9. (489 aa)
	MARS1	Methionyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (822 aa)
	PTPN11	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (593 aa)
	KNSTRN	Uncharacterized protein. (221 aa)
	U3J954_ANAPP	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (660 aa)
	ENSAPLP00000017981	Receptor protein-tyrosine kinase. (513 aa)
	ENSAPLP00000018027	Uncharacterized protein. (85 aa)
	MED1	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1474 aa)
	ZFP36L2	ZFP36 ring finger protein like 2. (572 aa)
	ZPR1	ZPR1 zinc finger. (229 aa)
	ENSAPLP00000027023	IMD domain-containing protein. (116 aa)
	ERBB4	Receptor protein-tyrosine kinase. (1317 aa)
	GAREM2	GRB2 associated regulator of MAPK1 subtype 2. (858 aa)
	ZFP36L1	ZFP36 ring finger protein like 1. (335 aa)
	BAIAP2	BAI1 associated protein 2. (557 aa)

Your Current Organism:

Anas platyrhynchos

NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DAB2	EGFR	ENSAPLP00000008982	ENSAPLP00000002564	DAB adaptor protein 2.	Receptor protein-tyrosine kinase.	0.411
DAB2	ENSAPLP00000017981	ENSAPLP00000008982	ENSAPLP00000017981	DAB adaptor protein 2.	Receptor protein-tyrosine kinase.	0.411
DAB2	ERBB4	ENSAPLP00000008982	ENSAPLP00000028809	DAB adaptor protein 2.	Receptor protein-tyrosine kinase.	0.411
EGFR	DAB2	ENSAPLP00000002564	ENSAPLP00000008982	Receptor protein-tyrosine kinase.	DAB adaptor protein 2.	0.411
EGFR	ERBB4	ENSAPLP00000002564	ENSAPLP00000028809	Receptor protein-tyrosine kinase.	Receptor protein-tyrosine kinase.	0.632
EGFR	PTPN11	ENSAPLP00000002564	ENSAPLP00000015227	Receptor protein-tyrosine kinase.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.647
EGFR	U3J954_ANAPP	ENSAPLP00000002564	ENSAPLP00000016032	Receptor protein-tyrosine kinase.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.647
ENSAPLP00000017981	DAB2	ENSAPLP00000017981	ENSAPLP00000008982	Receptor protein-tyrosine kinase.	DAB adaptor protein 2.	0.411
ENSAPLP00000017981	ERBB4	ENSAPLP00000017981	ENSAPLP00000028809	Receptor protein-tyrosine kinase.	Receptor protein-tyrosine kinase.	0.629
ENSAPLP00000017981	PTPN11	ENSAPLP00000017981	ENSAPLP00000015227	Receptor protein-tyrosine kinase.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.647
ENSAPLP00000017981	U3J954_ANAPP	ENSAPLP00000017981	ENSAPLP00000016032	Receptor protein-tyrosine kinase.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.647
ERBB4	DAB2	ENSAPLP00000028809	ENSAPLP00000008982	Receptor protein-tyrosine kinase.	DAB adaptor protein 2.	0.411
ERBB4	EGFR	ENSAPLP00000028809	ENSAPLP00000002564	Receptor protein-tyrosine kinase.	Receptor protein-tyrosine kinase.	0.632
ERBB4	ENSAPLP00000017981	ENSAPLP00000028809	ENSAPLP00000017981	Receptor protein-tyrosine kinase.	Receptor protein-tyrosine kinase.	0.629
ERBB4	PTPN11	ENSAPLP00000028809	ENSAPLP00000015227	Receptor protein-tyrosine kinase.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.647
ERBB4	U3J954_ANAPP	ENSAPLP00000028809	ENSAPLP00000016032	Receptor protein-tyrosine kinase.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.647
MARS1	MED1	ENSAPLP00000014689	ENSAPLP00000022023	Methionyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.501
MARS1	U3IBF2_ANAPP	ENSAPLP00000014689	ENSAPLP00000004574	Methionyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.501
MED1	MARS1	ENSAPLP00000022023	ENSAPLP00000014689	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Methionyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family.	0.501
PTPN11	EGFR	ENSAPLP00000015227	ENSAPLP00000002564	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	Receptor protein-tyrosine kinase.	0.647