(35 nodes) Scaffold protein binding network (Anas platyrhynchos)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CASP10	Caspase 10; Belongs to the peptidase C14A family. (538 aa)
	P2RX7	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (575 aa)
	LYN	Tyrosine-protein kinase. (535 aa)
	TBX5	T-box transcription factor 5. (537 aa)
	HOMER1	Homer scaffold protein 1. (355 aa)
	SHANK3	SH3 and multiple ankyrin repeat domains 3. (1647 aa)
	TBX4	T-box transcription factor 4. (495 aa)
	U3IP82_ANAPP	Uncharacterized protein. (206 aa)
	VCL	Vinculin. (1135 aa)
	DLL1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (728 aa)
	IL6ST	Interleukin 6 signal transducer. (933 aa)
	U3J0T1_ANAPP	Uncharacterized protein. (504 aa)
	CACNA1H	Calcium voltage-gated channel subunit alpha1 H. (2104 aa)
	GRM2	Glutamate metabotropic receptor 2. (882 aa)
	KCNQ1	Potassium voltage-gated channel subfamily Q member 1; Belongs to the potassium channel family. (690 aa)
	PHF6	PHD finger protein 6. (365 aa)
	CASP8	Caspase 8; Belongs to the peptidase C14A family. (466 aa)
	FYN	Tyrosine-protein kinase. (534 aa)
	U3J6D9_ANAPP	Uncharacterized protein; Belongs to the peptidase C14A family. (457 aa)
	CACNA1G	Calcium voltage-gated channel subunit alpha1 G. (2146 aa)
	U3J899_ANAPP	Uncharacterized protein. (907 aa)
	CIT	Citron Rho-interacting kinase; Plays a role in cytokinesis. Displays serine/threonine protein kinase activity; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (2070 aa)
	ENSAPLP00000019710	Uncharacterized protein. (398 aa)
	AKAP5	A-kinase anchoring protein 5. (569 aa)
	ENSAPLP00000021023	Uncharacterized protein. (302 aa)
	MAP3K7	Mitogen-activated protein kinase kinase kinase 7. (644 aa)
	ENSAPLP00000025362	Uncharacterized protein. (236 aa)
	ENSAPLP00000027023	IMD domain-containing protein. (116 aa)
	NCK2	Cytoplasmic protein. (380 aa)
	ENSAPLP00000027493	Uncharacterized protein. (128 aa)
	IKBKB	Inhibitor of nuclear factor kappa B kinase subunit beta. (778 aa)
	BAIAP2	BAI1 associated protein 2. (557 aa)
	CAV2	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (161 aa)
	ATP2B4	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1306 aa)
	ENSAPLP00000032898	IF rod domain-containing protein; Belongs to the intermediate filament family. (135 aa)

Your Current Organism:

Anas platyrhynchos

NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BAIAP2	NCK2	ENSAPLP00000030530	ENSAPLP00000027386	BAI1 associated protein 2.	Cytoplasmic protein.	0.708
BAIAP2	SHANK3	ENSAPLP00000030530	ENSAPLP00000008325	BAI1 associated protein 2.	SH3 and multiple ankyrin repeat domains 3.	0.427
CACNA1G	CACNA1H	ENSAPLP00000015720	ENSAPLP00000013748	Calcium voltage-gated channel subunit alpha1 G.	Calcium voltage-gated channel subunit alpha1 H.	0.444
CACNA1H	CACNA1G	ENSAPLP00000013748	ENSAPLP00000015720	Calcium voltage-gated channel subunit alpha1 H.	Calcium voltage-gated channel subunit alpha1 G.	0.444
CASP10	CASP8	ENSAPLP00000015101	ENSAPLP00000014720	Caspase 10; Belongs to the peptidase C14A family.	Caspase 8; Belongs to the peptidase C14A family.	0.889
CASP10	MAP3K7	ENSAPLP00000015101	ENSAPLP00000024103	Caspase 10; Belongs to the peptidase C14A family.	Mitogen-activated protein kinase kinase kinase 7.	0.448
CASP10	U3J6D9_ANAPP	ENSAPLP00000015101	ENSAPLP00000015066	Caspase 10; Belongs to the peptidase C14A family.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.914
CASP8	CASP10	ENSAPLP00000014720	ENSAPLP00000015101	Caspase 8; Belongs to the peptidase C14A family.	Caspase 10; Belongs to the peptidase C14A family.	0.889
CASP8	LYN	ENSAPLP00000014720	ENSAPLP00000005775	Caspase 8; Belongs to the peptidase C14A family.	Tyrosine-protein kinase.	0.532
CASP8	MAP3K7	ENSAPLP00000014720	ENSAPLP00000024103	Caspase 8; Belongs to the peptidase C14A family.	Mitogen-activated protein kinase kinase kinase 7.	0.448
CASP8	U3J6D9_ANAPP	ENSAPLP00000014720	ENSAPLP00000015066	Caspase 8; Belongs to the peptidase C14A family.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.910
CAV2	FYN	ENSAPLP00000030555	ENSAPLP00000014801	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Tyrosine-protein kinase.	0.489
ENSAPLP00000019710	ENSAPLP00000025362	ENSAPLP00000019710	ENSAPLP00000025362	Uncharacterized protein.	Uncharacterized protein.	0.917
ENSAPLP00000025362	ENSAPLP00000019710	ENSAPLP00000025362	ENSAPLP00000019710	Uncharacterized protein.	Uncharacterized protein.	0.917
ENSAPLP00000027023	NCK2	ENSAPLP00000027023	ENSAPLP00000027386	IMD domain-containing protein.	Cytoplasmic protein.	0.708
ENSAPLP00000027023	SHANK3	ENSAPLP00000027023	ENSAPLP00000008325	IMD domain-containing protein.	SH3 and multiple ankyrin repeat domains 3.	0.427
FYN	CAV2	ENSAPLP00000014801	ENSAPLP00000030555	Tyrosine-protein kinase.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.489
FYN	LYN	ENSAPLP00000014801	ENSAPLP00000005775	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.751
FYN	NCK2	ENSAPLP00000014801	ENSAPLP00000027386	Tyrosine-protein kinase.	Cytoplasmic protein.	0.539
FYN	VCL	ENSAPLP00000014801	ENSAPLP00000009699	Tyrosine-protein kinase.	Vinculin.	0.499