(13 nodes) Activation of cysteine-type endopeptidase activity network (Anas platyrhynchos)

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Your Input:
	RIPK2	Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (552 aa)
	CYFIP2	Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1253 aa)
	BAK1	BCL2 antagonist/killer 1. (306 aa)
	FADD	Uncharacterized protein. (195 aa)
	U3IBK2_ANAPP	Uncharacterized protein. (566 aa)
	ASPH	Aspartate beta-hydroxylase. (851 aa)
	LGMN	Legumain. (431 aa)
	CASP9	Caspase 9; Belongs to the peptidase C14A family. (446 aa)
	APAF1	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1247 aa)
	CASP8	Caspase 8; Belongs to the peptidase C14A family. (466 aa)
	U3J6D9_ANAPP	Uncharacterized protein; Belongs to the peptidase C14A family. (457 aa)
	CASP10	Caspase 10; Belongs to the peptidase C14A family. (538 aa)
	PAWR	Pro-apoptotic WT1 regulator. (208 aa)

Your Current Organism:

Anas platyrhynchos

NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APAF1	BAK1	ENSAPLP00000010171	ENSAPLP00000002503	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	BCL2 antagonist/killer 1.	0.752
APAF1	CASP10	ENSAPLP00000010171	ENSAPLP00000015101	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase 10; Belongs to the peptidase C14A family.	0.881
APAF1	CASP8	ENSAPLP00000010171	ENSAPLP00000014720	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase 8; Belongs to the peptidase C14A family.	0.935
APAF1	CASP9	ENSAPLP00000010171	ENSAPLP00000008534	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase 9; Belongs to the peptidase C14A family.	0.999
APAF1	FADD	ENSAPLP00000010171	ENSAPLP00000004592	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Uncharacterized protein.	0.602
APAF1	LGMN	ENSAPLP00000010171	ENSAPLP00000007636	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Legumain.	0.462
APAF1	U3J6D9_ANAPP	ENSAPLP00000010171	ENSAPLP00000015066	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.935
BAK1	APAF1	ENSAPLP00000002503	ENSAPLP00000010171	BCL2 antagonist/killer 1.	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	0.752
BAK1	CASP8	ENSAPLP00000002503	ENSAPLP00000014720	BCL2 antagonist/killer 1.	Caspase 8; Belongs to the peptidase C14A family.	0.628
BAK1	CASP9	ENSAPLP00000002503	ENSAPLP00000008534	BCL2 antagonist/killer 1.	Caspase 9; Belongs to the peptidase C14A family.	0.724
BAK1	U3J6D9_ANAPP	ENSAPLP00000002503	ENSAPLP00000015066	BCL2 antagonist/killer 1.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.473
CASP10	APAF1	ENSAPLP00000015101	ENSAPLP00000010171	Caspase 10; Belongs to the peptidase C14A family.	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	0.881
CASP10	CASP8	ENSAPLP00000015101	ENSAPLP00000014720	Caspase 10; Belongs to the peptidase C14A family.	Caspase 8; Belongs to the peptidase C14A family.	0.889
CASP10	CASP9	ENSAPLP00000015101	ENSAPLP00000008534	Caspase 10; Belongs to the peptidase C14A family.	Caspase 9; Belongs to the peptidase C14A family.	0.510
CASP10	FADD	ENSAPLP00000015101	ENSAPLP00000004592	Caspase 10; Belongs to the peptidase C14A family.	Uncharacterized protein.	0.997
CASP10	RIPK2	ENSAPLP00000015101	ENSAPLP00000006481	Caspase 10; Belongs to the peptidase C14A family.	Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains.	0.438
CASP10	U3IBK2_ANAPP	ENSAPLP00000015101	ENSAPLP00000004624	Caspase 10; Belongs to the peptidase C14A family.	Uncharacterized protein.	0.438
CASP10	U3J6D9_ANAPP	ENSAPLP00000015101	ENSAPLP00000015066	Caspase 10; Belongs to the peptidase C14A family.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.914
CASP8	APAF1	ENSAPLP00000014720	ENSAPLP00000010171	Caspase 8; Belongs to the peptidase C14A family.	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	0.935
CASP8	BAK1	ENSAPLP00000014720	ENSAPLP00000002503	Caspase 8; Belongs to the peptidase C14A family.	BCL2 antagonist/killer 1.	0.628