(39 nodes) SMAD/FHA domain superfamily network (Anas platyrhynchos)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CEP170	Centrosomal protein 170. (1649 aa)
	IRF4	Interferon regulatory factor 4. (446 aa)
	ENSAPLP00000030066	IRF-3 domain-containing protein. (225 aa)
	CEP170B	Centrosomal protein 170B. (1669 aa)
	AFDN	Afadin, adherens junction formation factor. (1772 aa)
	IRF7	Interferon regulatory factor 7. (523 aa)
	KIF14	Kinesin family member 14; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1642 aa)
	ENSAPLP00000024821	IRF tryptophan pentad repeat domain-containing protein. (378 aa)
	FHAD1	Forkhead associated phosphopeptide binding domain 1. (1094 aa)
	SMAD5	Mothers against decapentaplegic homolog. (465 aa)
	KIF16B	Kinesin family member 16B; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1892 aa)
	KIF13B	Kinesin family member 13B; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1955 aa)
	PPP1R8	Protein phosphatase 1 regulatory subunit 8. (355 aa)
	PHLDB1	Pleckstrin homology like domain family B member 1. (1372 aa)
	ENSAPLP00000016447	Uncharacterized protein. (672 aa)
	APTX	Aprataxin. (320 aa)
	PHF12	PHD finger protein 12. (920 aa)
	RNF8	E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (612 aa)
	SLC4A1AP	Solute carrier family 4 member 1 adaptor protein. (508 aa)
	SMAD1	Mothers against decapentaplegic homolog. (465 aa)
	IRF8	IRF-3 domain-containing protein. (306 aa)
	CHEK2	Checkpoint kinase 2. (524 aa)
	IRF6	Interferon regulatory factor 6. (467 aa)
	SMAD9	Mothers against decapentaplegic homolog. (476 aa)
	APLF	Aprataxin and PNKP like factor. (507 aa)
	FOXK1	Forkhead box K1. (694 aa)
	SLMAP	Sarcolemma associated protein. (843 aa)
	MCRS1	Microspherule protein 1. (531 aa)
	FOXK2	Forkhead box K2. (901 aa)
	SMAD3	Mothers against decapentaplegic homolog. (426 aa)
	KIF1B	Kinesin family member 1B; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1768 aa)
	NBN	Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (748 aa)
	IRF5	IRF-3 domain-containing protein. (174 aa)
	KIF13A	Kinesin family member 13A; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1863 aa)
	SMAD2	Mothers against decapentaplegic homolog. (467 aa)
	SMAD4	Mothers against decapentaplegic homolog. (551 aa)
	CHFR	Checkpoint with forkhead and ring finger domains. (677 aa)
	SMAD7	Mothers against decapentaplegic homolog. (369 aa)
	SMAD6	Mothers against decapentaplegic homolog. (486 aa)

Your Current Organism:

Anas platyrhynchos

NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APLF	APTX	ENSAPLP00000008807	ENSAPLP00000015505	Aprataxin and PNKP like factor.	Aprataxin.	0.747
APLF	CHFR	ENSAPLP00000008807	ENSAPLP00000002407	Aprataxin and PNKP like factor.	Checkpoint with forkhead and ring finger domains.	0.747
APTX	APLF	ENSAPLP00000015505	ENSAPLP00000008807	Aprataxin.	Aprataxin and PNKP like factor.	0.747
APTX	CHFR	ENSAPLP00000015505	ENSAPLP00000002407	Aprataxin.	Checkpoint with forkhead and ring finger domains.	0.586
CHEK2	NBN	ENSAPLP00000009352	ENSAPLP00000006048	Checkpoint kinase 2.	Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis.	0.797
CHEK2	RNF8	ENSAPLP00000009352	ENSAPLP00000014631	Checkpoint kinase 2.	E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...]	0.706
CHFR	APLF	ENSAPLP00000002407	ENSAPLP00000008807	Checkpoint with forkhead and ring finger domains.	Aprataxin and PNKP like factor.	0.747
CHFR	APTX	ENSAPLP00000002407	ENSAPLP00000015505	Checkpoint with forkhead and ring finger domains.	Aprataxin.	0.586
KIF13A	KIF16B	ENSAPLP00000004986	ENSAPLP00000023194	Kinesin family member 13A; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Kinesin family member 16B; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.448
KIF13B	KIF16B	ENSAPLP00000022626	ENSAPLP00000023194	Kinesin family member 13B; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Kinesin family member 16B; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.474
KIF13B	KIF1B	ENSAPLP00000022626	ENSAPLP00000006379	Kinesin family member 13B; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Kinesin family member 1B; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.406
KIF14	MCRS1	ENSAPLP00000025193	ENSAPLP00000007669	Kinesin family member 14; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Microspherule protein 1.	0.429
KIF16B	KIF13A	ENSAPLP00000023194	ENSAPLP00000004986	Kinesin family member 16B; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Kinesin family member 13A; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.448
KIF16B	KIF13B	ENSAPLP00000023194	ENSAPLP00000022626	Kinesin family member 16B; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Kinesin family member 13B; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.474
KIF1B	KIF13B	ENSAPLP00000006379	ENSAPLP00000022626	Kinesin family member 1B; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Kinesin family member 13B; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.406
MCRS1	KIF14	ENSAPLP00000007669	ENSAPLP00000025193	Microspherule protein 1.	Kinesin family member 14; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.429
NBN	CHEK2	ENSAPLP00000006048	ENSAPLP00000009352	Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis.	Checkpoint kinase 2.	0.797
NBN	RNF8	ENSAPLP00000006048	ENSAPLP00000014631	Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis.	E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...]	0.712
RNF8	CHEK2	ENSAPLP00000014631	ENSAPLP00000009352	E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...]	Checkpoint kinase 2.	0.706
RNF8	NBN	ENSAPLP00000014631	ENSAPLP00000006048	E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...]	Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis.	0.712