(25 nodes) Four-helical cytokine-like, core network (Anas platyrhynchos)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	GH1	Uncharacterized protein. (222 aa)
	IL22	Interleukin 22. (197 aa)
	LIF	LIF interleukin 6 family cytokine. (257 aa)
	ENSAPLP00000031142	Uncharacterized protein. (405 aa)
	CSF1	Uncharacterized protein. (472 aa)
	ENSAPLP00000028410	Uncharacterized protein. (157 aa)
	ENSAPLP00000027603	Uncharacterized protein. (170 aa)
	CNTF	Ciliary neurotrophic factor. (196 aa)
	IL5	Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (139 aa)
	ENSAPLP00000021652	Uncharacterized protein. (243 aa)
	CSF3	Colony stimulating factor 3. (203 aa)
	ENSAPLP00000020826	Uncharacterized protein. (210 aa)
	IL6	Uncharacterized protein. (350 aa)
	IL19	Interleukin 19. (176 aa)
	IL10	Interleukin 10. (177 aa)
	IFNG	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (164 aa)
	PRL	Prolactin. (229 aa)
	IL4	Uncharacterized protein. (136 aa)
	KITLG	Kit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (285 aa)
	U3IUJ9_ANAPP	Uncharacterized protein. (353 aa)
	IL21	Interleukin; Belongs to the IL-15/IL-21 family. (145 aa)
	IL-2	Interleukin; Belongs to the IL-15/IL-21 family. (140 aa)
	IL12A	Interleukin-12 subunit alpha; Belongs to the IL-6 superfamily. (214 aa)
	IL15	Interleukin; Belongs to the IL-15/IL-21 family. (223 aa)
	U3I6M6_ANAPP	Uncharacterized protein. (184 aa)

Your Current Organism:

Anas platyrhynchos

NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CNTF	IL6	ENSAPLP00000022609	ENSAPLP00000020478	Ciliary neurotrophic factor.	Uncharacterized protein.	0.611
CNTF	LIF	ENSAPLP00000022609	ENSAPLP00000032193	Ciliary neurotrophic factor.	LIF interleukin 6 family cytokine.	0.520
CSF1	CSF3	ENSAPLP00000031027	ENSAPLP00000021424	Uncharacterized protein.	Colony stimulating factor 3.	0.502
CSF1	IFNG	ENSAPLP00000031027	ENSAPLP00000012661	Uncharacterized protein.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.452
CSF1	IL10	ENSAPLP00000031027	ENSAPLP00000015242	Uncharacterized protein.	Interleukin 10.	0.575
CSF1	IL4	ENSAPLP00000031027	ENSAPLP00000011598	Uncharacterized protein.	Uncharacterized protein.	0.545
CSF1	IL6	ENSAPLP00000031027	ENSAPLP00000020478	Uncharacterized protein.	Uncharacterized protein.	0.598
CSF3	CSF1	ENSAPLP00000021424	ENSAPLP00000031027	Colony stimulating factor 3.	Uncharacterized protein.	0.502
CSF3	ENSAPLP00000031142	ENSAPLP00000021424	ENSAPLP00000031142	Colony stimulating factor 3.	Uncharacterized protein.	0.465
CSF3	IFNG	ENSAPLP00000021424	ENSAPLP00000012661	Colony stimulating factor 3.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.630
CSF3	IL-2	ENSAPLP00000021424	ENSAPLP00000006460	Colony stimulating factor 3.	Interleukin; Belongs to the IL-15/IL-21 family.	0.562
CSF3	IL10	ENSAPLP00000021424	ENSAPLP00000015242	Colony stimulating factor 3.	Interleukin 10.	0.718
CSF3	IL15	ENSAPLP00000021424	ENSAPLP00000004404	Colony stimulating factor 3.	Interleukin; Belongs to the IL-15/IL-21 family.	0.558
CSF3	IL4	ENSAPLP00000021424	ENSAPLP00000011598	Colony stimulating factor 3.	Uncharacterized protein.	0.611
CSF3	IL6	ENSAPLP00000021424	ENSAPLP00000020478	Colony stimulating factor 3.	Uncharacterized protein.	0.820
CSF3	KITLG	ENSAPLP00000021424	ENSAPLP00000011212	Colony stimulating factor 3.	Kit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family.	0.586
ENSAPLP00000021652	ENSAPLP00000028410	ENSAPLP00000021652	ENSAPLP00000028410	Uncharacterized protein.	Uncharacterized protein.	0.900
ENSAPLP00000021652	IFNG	ENSAPLP00000021652	ENSAPLP00000012661	Uncharacterized protein.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.900
ENSAPLP00000021652	IL-2	ENSAPLP00000021652	ENSAPLP00000006460	Uncharacterized protein.	Interleukin; Belongs to the IL-15/IL-21 family.	0.461
ENSAPLP00000021652	IL6	ENSAPLP00000021652	ENSAPLP00000020478	Uncharacterized protein.	Uncharacterized protein.	0.435