(22 nodes) Toll/interleukin-1 receptor homology (TIR) domain superfamily network (Anas platyrhynchos)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	IL1RL1	Interleukin 1 receptor like 1. (519 aa)
	U3IAH1_ANAPP	Uncharacterized protein. (584 aa)
	U3I9U3_ANAPP	Uncharacterized protein. (552 aa)
	TLR7	Toll like receptor 7; Belongs to the Toll-like receptor family. (1089 aa)
	IL1RAPL1	Interleukin 1 receptor accessory protein like 1. (622 aa)
	IL17RD	Interleukin 17 receptor D. (736 aa)
	TLR6	Toll like receptor 6; Belongs to the Toll-like receptor family. (818 aa)
	TIRAP	TIR domain containing adaptor protein. (219 aa)
	TLR5	TIR domain-containing protein; Belongs to the Toll-like receptor family. (878 aa)
	IL18RAP	Interleukin 18 receptor accessory protein. (820 aa)
	TLR3	Toll like receptor 3; Belongs to the Toll-like receptor family. (914 aa)
	TLR-15	TIR domain-containing protein. (863 aa)
	PIK3AP1	Phosphoinositide-3-kinase adaptor protein 1. (785 aa)
	TLR2	Toll like receptor 2; Belongs to the Toll-like receptor family. (713 aa)
	TLR4	Toll like receptor 4. (843 aa)
	IL1RAPL2	Interleukin 1 receptor accessory protein like 2. (686 aa)
	ENSAPLP00000018903	Uncharacterized protein. (582 aa)
	ENSAPLP00000018963	TIR domain-containing protein. (795 aa)
	SIGIRR	Single Ig and TIR domain containing. (454 aa)
	MYD88	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (311 aa)
	BANK1	B cell scaffold protein with ankyrin repeats 1. (737 aa)
	ENSAPLP00000031408	TIR domain-containing protein. (102 aa)

Your Current Organism:

Anas platyrhynchos

NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSAPLP00000018903	IL1RL1	ENSAPLP00000018903	ENSAPLP00000004472	Uncharacterized protein.	Interleukin 1 receptor like 1.	0.949
ENSAPLP00000018903	MYD88	ENSAPLP00000018903	ENSAPLP00000028214	Uncharacterized protein.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.778
ENSAPLP00000018903	U3I9U3_ANAPP	ENSAPLP00000018903	ENSAPLP00000004014	Uncharacterized protein.	Uncharacterized protein.	0.873
ENSAPLP00000018903	U3IAH1_ANAPP	ENSAPLP00000018903	ENSAPLP00000004242	Uncharacterized protein.	Uncharacterized protein.	0.873
ENSAPLP00000018963	TLR4	ENSAPLP00000018963	ENSAPLP00000012401	TIR domain-containing protein.	Toll like receptor 4.	0.574
ENSAPLP00000031408	TLR4	ENSAPLP00000031408	ENSAPLP00000012401	TIR domain-containing protein.	Toll like receptor 4.	0.574
IL1RL1	ENSAPLP00000018903	ENSAPLP00000004472	ENSAPLP00000018903	Interleukin 1 receptor like 1.	Uncharacterized protein.	0.949
IL1RL1	MYD88	ENSAPLP00000004472	ENSAPLP00000028214	Interleukin 1 receptor like 1.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.971
IL1RL1	U3I9U3_ANAPP	ENSAPLP00000004472	ENSAPLP00000004014	Interleukin 1 receptor like 1.	Uncharacterized protein.	0.932
MYD88	ENSAPLP00000018903	ENSAPLP00000028214	ENSAPLP00000018903	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	Uncharacterized protein.	0.778
MYD88	IL1RL1	ENSAPLP00000028214	ENSAPLP00000004472	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	Interleukin 1 receptor like 1.	0.971
MYD88	SIGIRR	ENSAPLP00000028214	ENSAPLP00000027656	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	Single Ig and TIR domain containing.	0.682
MYD88	TIRAP	ENSAPLP00000028214	ENSAPLP00000001350	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	TIR domain containing adaptor protein.	0.998
MYD88	TLR-15	ENSAPLP00000028214	ENSAPLP00000009634	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	TIR domain-containing protein.	0.782
MYD88	TLR2	ENSAPLP00000028214	ENSAPLP00000011131	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	Toll like receptor 2; Belongs to the Toll-like receptor family.	0.985
MYD88	TLR3	ENSAPLP00000028214	ENSAPLP00000008663	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	Toll like receptor 3; Belongs to the Toll-like receptor family.	0.987
MYD88	TLR4	ENSAPLP00000028214	ENSAPLP00000012401	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	Toll like receptor 4.	0.999
MYD88	TLR5	ENSAPLP00000028214	ENSAPLP00000000694	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	TIR domain-containing protein; Belongs to the Toll-like receptor family.	0.988
MYD88	TLR6	ENSAPLP00000028214	ENSAPLP00000001470	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	Toll like receptor 6; Belongs to the Toll-like receptor family.	0.956
MYD88	TLR7	ENSAPLP00000028214	ENSAPLP00000003630	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	Toll like receptor 7; Belongs to the Toll-like receptor family.	0.997