(119 nodes) Apoptosis network (Anas platyrhynchos)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	GAS2	Growth arrest specific 2. (314 aa)
	U3I3D9_ANAPP	H15 domain-containing protein. (225 aa)
	U3I3J8_ANAPP	Uncharacterized protein. (207 aa)
	PRKCD	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (703 aa)
	BAK1	BCL2 antagonist/killer 1. (306 aa)
	HMGB2	High mobility group box 2. (207 aa)
	DFFB	DNA fragmentation factor subunit beta. (332 aa)
	DSP	Desmoplakin. (2861 aa)
	APPL1	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1. (696 aa)
	U3IA97_ANAPP	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (242 aa)
	LY96	Lymphocyte antigen 96. (155 aa)
	KPNA1	Importin subunit alpha; Belongs to the importin alpha family. (538 aa)
	FADD	Uncharacterized protein. (195 aa)
	AVEN	Apoptosis and caspase activation inhibitor. (359 aa)
	FASLG	Fas ligand; Belongs to the tumor necrosis factor family. (237 aa)
	GSN	Gelsolin. (778 aa)
	U3IDI2_ANAPP	Uncharacterized protein. (357 aa)
	U3IDU8_ANAPP	H15 domain-containing protein. (325 aa)
	HP1BP3	Heterochromatin protein 1 binding protein 3. (572 aa)
	SCIN	Scinderin. (717 aa)
	DFFA	DNA fragmentation factor subunit alpha. (311 aa)
	U3IFF2_ANAPP	Uncharacterized protein; Belongs to the intermediate filament family. (586 aa)
	OMA1	OMA1 zinc metallopeptidase. (532 aa)
	SH3GLB2	SH3 domain containing GRB2 like, endophilin B2. (388 aa)
	DIABLO	Uncharacterized protein. (241 aa)
	TJP1	Tight junction protein 1; Belongs to the MAGUK family. (1715 aa)
	CASP9	Caspase 9; Belongs to the peptidase C14A family. (446 aa)
	BID	BH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (193 aa)
	SATB1	DNA-binding protein SATB. (787 aa)
	DCC	DCC netrin 1 receptor. (1437 aa)
	NMT1	Glycylpeptide N-tetradecanoyltransferase; Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins; Belongs to the NMT family. (496 aa)
	CLSPN	Claspin. (1374 aa)
	KPNB1	Karyopherin subunit beta 1. (907 aa)
	CASP6	Caspase 6; Belongs to the peptidase C14A family. (295 aa)
	APAF1	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1247 aa)
	BOK	Uncharacterized protein. (213 aa)
	FILIP1L	Filamin A interacting protein 1 like. (1063 aa)
	U3ITT3_ANAPP	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
	LMNB2	Lamin B2; Belongs to the intermediate filament family. (600 aa)
	BCL2L11	BCL2 like 11. (159 aa)
	TLR4	Toll like receptor 4. (843 aa)
	IGDCC4	Immunoglobulin superfamily DCC subclass member 4. (1093 aa)
	CASP7	Caspase 7; Belongs to the peptidase C14A family. (309 aa)
	CTNNB1	Catenin beta 1. (781 aa)
	PKP1	Plakophilin 1. (734 aa)
	FNTA	Farnesyltransferase, CAAX box, alpha. (348 aa)
	U3J3X4_ANAPP	LRRCT domain-containing protein. (553 aa)
	CASP8	Caspase 8; Belongs to the peptidase C14A family. (466 aa)
	GSDME	Gasdermin E. (499 aa)
	SPTAN1	Spectrin alpha, non-erythrocytic 1. (2433 aa)
	APPL2	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2. (658 aa)
	CASP3	Caspase 3; Belongs to the peptidase C14A family. (306 aa)
	CFLAR	CASP8 and FADD like apoptosis regulator; Belongs to the peptidase C14A family. (489 aa)
	RIPK1	Receptor interacting serine/threonine kinase 1. (690 aa)
	BMX	Tyrosine-protein kinase. (651 aa)
	NEO1	Neogenin 1. (1449 aa)
	IGDCC3	Immunoglobulin superfamily DCC subclass member 3. (790 aa)
	SEPT5	Septin-type G domain-containing protein; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (485 aa)
	HMGB3	High mobility group box 3. (341 aa)
	TNFSF10	TNF superfamily member 10; Belongs to the tumor necrosis factor family. (295 aa)
	ENSAPLP00000016714	FERM_N_2 domain-containing protein. (80 aa)
	ENSAPLP00000017448	Microtubule-associated protein. (750 aa)
	PTK2	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1119 aa)
	ENSAPLP00000017975	Uncharacterized protein. (51 aa)
	MAPK8	Mitogen-activated protein kinase. (384 aa)
	APIP	Methylthioribulose-1-phosphate dehydratase; Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway. May play a role in apoptosis. (281 aa)
	FAS	Uncharacterized protein. (461 aa)
	BCL2	BCL2 apoptosis regulator. (239 aa)
	BCL2L10	Uncharacterized protein. (89 aa)
	ENSAPLP00000020297	H15 domain-containing protein. (218 aa)
	YWHAG	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma; Belongs to the 14-3-3 family. (353 aa)
	ADD1	Adducin 1. (857 aa)
	ENSAPLP00000021206	DUF4203 domain-containing protein. (110 aa)
	DYNLL2	Dynein light chain. (89 aa)
	DAPK3	Death associated protein kinase 3. (637 aa)
	BMF	Bcl2 modifying factor. (236 aa)
	CAPG	Capping actin protein, gelsolin like. (508 aa)
	ENSAPLP00000022389	Dynein light chain. (89 aa)
	EPPK1	Uncharacterized protein. (3162 aa)
	STK24	Serine/threonine kinase 24. (431 aa)
	PLEC	Plectin. (3860 aa)
	BCAP29	B cell receptor associated protein 29. (345 aa)
	TJP3	Tight junction protein 3; Belongs to the MAGUK family. (760 aa)
	OPA1	Dynamin-type G domain-containing protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (1114 aa)
	HMGB1	High mobility group box 1. (281 aa)
	MAP2	Microtubule-associated protein. (1879 aa)
	UNC5B	Ig-like domain-containing protein. (267 aa)
	ENSAPLP00000024204	Microtubule-associated protein. (187 aa)
	TRAF2	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (533 aa)
	TRADD	TNFRSF1A associated via death domain. (429 aa)
	DNM1L	Dynamin 1 like; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (750 aa)
	XIAP	X-linked inhibitor of apoptosis. (493 aa)
	ENSAPLP00000024928	Dynein light chain. (89 aa)
	APC2	APC regulator of WNT signaling pathway 2. (1940 aa)
	DSG2	Desmoglein 2. (1005 aa)
	BCL2L1	BCL2 like 1. (238 aa)
	SH3GLB1	SH3 domain containing GRB2 like, endophilin B1. (387 aa)
	DYNLL1	Dynein light chain. (89 aa)
	U3HZQ3_ANAPP	Uncharacterized protein; Belongs to the peptidase C14A family. (268 aa)
	PRKCQ	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (744 aa)
	NPVF	Neuropeptide VF precursor. (208 aa)
	LMNB1	Lamin B1; Belongs to the intermediate filament family. (535 aa)
	STK26	Serine/threonine kinase 26. (416 aa)
	ENSAPLP00000027848	Protein kinase domain-containing protein. (165 aa)
	ENSAPLP00000027884	Septin-type G domain-containing protein; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (476 aa)
	DBNL	Drebrin like. (290 aa)
	DAPK2	Death associated protein kinase 2. (594 aa)
	ENSAPLP00000030759	DUF4203 domain-containing protein. (244 aa)
	ENSAPLP00000030826	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (121 aa)
	APC	APC regulator of WNT signaling pathway. (2852 aa)
	TICAM1	TRIF-NTD domain-containing protein. (507 aa)
	ENSAPLP00000031055	H15 domain-containing protein. (218 aa)
	DAPK1	Death associated protein kinase 1. (1284 aa)
	H1-0	H1 histone family member 0. (194 aa)
	ENSAPLP00000031705	Uncharacterized protein. (155 aa)
	STK25	Protein kinase domain-containing protein. (487 aa)
	ROCK1	Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1384 aa)
	TJP2	Uncharacterized protein; Belongs to the MAGUK family. (1453 aa)
	LMNA	Lamin A/C; Belongs to the intermediate filament family. (502 aa)

Your Current Organism:

Anas platyrhynchos

NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADD1	APAF1	ENSAPLP00000020706	ENSAPLP00000010171	Adducin 1.	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	0.597
ADD1	CASP3	ENSAPLP00000020706	ENSAPLP00000015062	Adducin 1.	Caspase 3; Belongs to the peptidase C14A family.	0.603
APAF1	ADD1	ENSAPLP00000010171	ENSAPLP00000020706	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Adducin 1.	0.597
APAF1	APIP	ENSAPLP00000010171	ENSAPLP00000018793	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Methylthioribulose-1-phosphate dehydratase; Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway. May play a role in apoptosis.	0.940
APAF1	AVEN	ENSAPLP00000010171	ENSAPLP00000004654	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Apoptosis and caspase activation inhibitor.	0.963
APAF1	BAK1	ENSAPLP00000010171	ENSAPLP00000002503	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	BCL2 antagonist/killer 1.	0.752
APAF1	BCL2	ENSAPLP00000010171	ENSAPLP00000019939	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	BCL2 apoptosis regulator.	0.927
APAF1	BCL2L1	ENSAPLP00000010171	ENSAPLP00000025626	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	BCL2 like 1.	0.873
APAF1	BCL2L10	ENSAPLP00000010171	ENSAPLP00000020198	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Uncharacterized protein.	0.670
APAF1	BCL2L11	ENSAPLP00000010171	ENSAPLP00000011514	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	BCL2 like 11.	0.503
APAF1	BID	ENSAPLP00000010171	ENSAPLP00000008644	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	BH3-interacting domain death agonist; Counters the protective effect of Bcl-2.	0.477
APAF1	BMF	ENSAPLP00000010171	ENSAPLP00000021735	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Bcl2 modifying factor.	0.430
APAF1	BOK	ENSAPLP00000010171	ENSAPLP00000010265	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Uncharacterized protein.	0.670
APAF1	CASP3	ENSAPLP00000010171	ENSAPLP00000015062	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase 3; Belongs to the peptidase C14A family.	0.960
APAF1	CASP6	ENSAPLP00000010171	ENSAPLP00000010155	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase 6; Belongs to the peptidase C14A family.	0.883
APAF1	CASP7	ENSAPLP00000010171	ENSAPLP00000013223	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase 7; Belongs to the peptidase C14A family.	0.929
APAF1	CASP8	ENSAPLP00000010171	ENSAPLP00000014720	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase 8; Belongs to the peptidase C14A family.	0.935
APAF1	CASP9	ENSAPLP00000010171	ENSAPLP00000008534	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase 9; Belongs to the peptidase C14A family.	0.999
APAF1	CFLAR	ENSAPLP00000010171	ENSAPLP00000015177	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	CASP8 and FADD like apoptosis regulator; Belongs to the peptidase C14A family.	0.799
APAF1	DIABLO	ENSAPLP00000010171	ENSAPLP00000006428	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Uncharacterized protein.	0.953