STRINGSTRING
FURIN FURIN ITGB6 ITGB6 ITGAV ITGAV SMAD3 SMAD3 U3IIA8_ANAPP U3IIA8_ANAPP ITGB5 ITGB5 U3IIX6_ANAPP U3IIX6_ANAPP SKIL SKIL ATP1B4 ATP1B4 IRX2 IRX2 U3INX3_ANAPP U3INX3_ANAPP BAMBI BAMBI SKI SKI SMURF2 SMURF2 TGFBR1 TGFBR1 PRKCZ PRKCZ MKX MKX STRAP STRAP TGFB2 TGFB2 TGFB3 TGFB3 NEDD4L NEDD4L PARD3B PARD3B ENSAPLP00000031478 ENSAPLP00000031478 WWTR1 WWTR1 FKBP1A FKBP1A ENSAPLP00000023172 ENSAPLP00000023172 ENSAPLP00000022416 ENSAPLP00000022416 FKBP1B FKBP1B CCNT2 CCNT2 CDK9 CDK9 IRX3 IRX3 SP1 SP1 ENSAPLP00000020204 ENSAPLP00000020204 NCOR1 NCOR1 TGIF2 TGIF2 KXD1 KXD1 TGIF1 TGIF1 TGFBR2 TGFBR2 ITGB8 ITGB8 IRX1 IRX1 ENSAPLP00000017660 ENSAPLP00000017660 MEIS1 MEIS1 ENSAPLP00000016622 ENSAPLP00000016622 PARD6A PARD6A SNW1 SNW1 ARHGEF18 ARHGEF18 LTBP2 LTBP2 PARP1 PARP1 CBL CBL MTMR4 MTMR4 LTBP1 LTBP1 RNF111 RNF111 ENSAPLP00000026459 ENSAPLP00000026459 IRX4 IRX4 IRX5 IRX5 SMURF1 SMURF1 ENSAPLP00000023897 ENSAPLP00000023897 SMAD7 SMAD7 PMEPA1 PMEPA1 PARD3 PARD3 SMAD4 SMAD4 STUB1 STUB1 ITGB3 ITGB3 ZFYVE9 ZFYVE9 SMAD2 SMAD2 RPS27A RPS27A FBN1 FBN1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FURINFurin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family. (789 aa)
ITGB6Integrin beta; Belongs to the integrin beta chain family. (722 aa)
ITGAVIntegrin subunit alpha V; Belongs to the integrin alpha chain family. (1044 aa)
SMAD3Mothers against decapentaplegic homolog. (426 aa)
U3IIA8_ANAPPHomeobox domain-containing protein. (248 aa)
ITGB5Integrin beta; Belongs to the integrin beta chain family. (894 aa)
U3IIX6_ANAPPUncharacterized protein. (923 aa)
SKILSKI like proto-oncogene. (689 aa)
ATP1B4Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (315 aa)
IRX2Iroquois homeobox 2. (441 aa)
U3INX3_ANAPPTGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (567 aa)
BAMBIBMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (259 aa)
SKISKI proto-oncogene. (744 aa)
SMURF2SMAD specific E3 ubiquitin protein ligase 2. (682 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (592 aa)
MKXMohawk homeobox. (353 aa)
STRAPSerine/threonine kinase receptor associated protein. (804 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
TGFB3Transforming growth factor beta 3. (458 aa)
NEDD4LNEDD4 like E3 ubiquitin protein ligase. (1331 aa)
PARD3BPar-3 family cell polarity regulator beta. (1201 aa)
ENSAPLP00000031478PARP-type domain-containing protein. (95 aa)
WWTR1WW domain containing transcription regulator 1. (269 aa)
FKBP1APeptidylprolyl isomerase. (58 aa)
ENSAPLP00000023172Uncharacterized protein. (215 aa)
ENSAPLP00000022416Homeobox_KN domain-containing protein. (76 aa)
FKBP1BPeptidylprolyl isomerase. (224 aa)
CCNT2Cyclin T2; Belongs to the cyclin family. (748 aa)
CDK9Cyclin dependent kinase 9. (403 aa)
IRX3Iroquois homeobox 3. (466 aa)
SP1Sp1 transcription factor. (683 aa)
ENSAPLP00000020204Uncharacterized protein. (83 aa)
NCOR1GPS2_interact domain-containing protein. (221 aa)
TGIF2TGFB induced factor homeobox 2. (331 aa)
KXD1KxDL motif containing 1. (353 aa)
TGIF1TGFB induced factor homeobox 1. (312 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (575 aa)
ITGB8Integrin beta; Belongs to the integrin beta chain family. (786 aa)
IRX1Iroquois homeobox 1. (469 aa)
ENSAPLP00000017660Uncharacterized protein. (65 aa)
MEIS1Meis homeobox 1. (465 aa)
ENSAPLP00000016622Uncharacterized protein. (91 aa)
PARD6APar-6 family cell polarity regulator alpha. (357 aa)
SNW1SNW domain containing 1. (538 aa)
ARHGEF18Uncharacterized protein. (1015 aa)
LTBP2Latent transforming growth factor beta binding protein 2. (1502 aa)
PARP1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (992 aa)
CBLCbl proto-oncogene. (814 aa)
MTMR4Myotubularin related protein 4. (1141 aa)
LTBP1Latent transforming growth factor beta binding protein 1. (1316 aa)
RNF111Ring finger protein 111. (1017 aa)
ENSAPLP00000026459CYCLIN domain-containing protein; Belongs to the cyclin family. (294 aa)
IRX4Iroquois homeobox 4. (492 aa)
IRX5Iroquois homeobox 5. (468 aa)
SMURF1E3 ubiquitin-protein ligase. (788 aa)
ENSAPLP00000023897Uncharacterized protein. (208 aa)
SMAD7Mothers against decapentaplegic homolog. (369 aa)
PMEPA1Prostate transmembrane protein, androgen induced 1. (202 aa)
PARD3Par-3 family cell polarity regulator. (1362 aa)
SMAD4Mothers against decapentaplegic homolog. (551 aa)
STUB1STIP1 homology and U-box containing protein 1. (330 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (1055 aa)
ZFYVE9Zinc finger FYVE-type containing 9. (706 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
RPS27AUbiquitin-like domain-containing protein. (156 aa)
FBN1Fibrillin 1. (2824 aa)
Your Current Organism:
Anas platyrhynchos
NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard
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