STRINGSTRING
EXD2 EXD2 RMI2 RMI2 POLH POLH RMI1 RMI1 U3I2H1_ANAPP U3I2H1_ANAPP RPA2 RPA2 RAD51AP1 RAD51AP1 RFC5 RFC5 RAD51 RAD51 XRCC2 XRCC2 POLK POLK POLD3 POLD3 RPS27A RPS27A TOP3A TOP3A NBN NBN BLM BLM RFC4 RFC4 POLE2 POLE2 BRCA2 BRCA2 MEIOB MEIOB GEN1 GEN1 BRIP1 BRIP1 RFC2 RFC2 POLE POLE RFC3 RFC3 RFC1 RFC1 ATM ATM TDRD3 TDRD3 RAD51C RAD51C CHEK1 CHEK1 EXO1 EXO1 BARD1 BARD1 DNA2 DNA2 RAD51B RAD51B KAT7 KAT7 KXD1 KXD1 RCBTB2 RCBTB2 POLD2 POLD2 MRE11 MRE11 EME1 EME1 ENSAPLP00000022406 ENSAPLP00000022406 RECQL4 RECQL4 RBBP8 RBBP8 SPIDR SPIDR PALB2 PALB2 ENSAPLP00000023897 ENSAPLP00000023897 RCBTB1 RCBTB1 POLE4 POLE4 XRCC3 XRCC3 BRCA1 BRCA1 ENSAPLP00000026881 ENSAPLP00000026881 PCNA PCNA ENSAPLP00000029564 ENSAPLP00000029564 SLX4 SLX4 RPA1 RPA1 RPA3 RPA3 SLX1 SLX1 POLE3 POLE3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EXD2Exonuclease 3'-5' domain containing 2. (767 aa)
RMI2RecQ mediated genome instability 2. (139 aa)
POLHDNA polymerase eta. (679 aa)
RMI1RecQ mediated genome instability 1. (619 aa)
U3I2H1_ANAPPUncharacterized protein. (1351 aa)
RPA2Replication protein A2. (269 aa)
RAD51AP1RAD51 associated protein 1. (400 aa)
RFC5Replication factor C subunit 5. (211 aa)
RAD51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa)
XRCC2X-ray repair cross complementing 2. (369 aa)
POLKDNA polymerase kappa. (866 aa)
POLD3Uncharacterized protein. (464 aa)
RPS27AUbiquitin-like domain-containing protein. (156 aa)
TOP3ADNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1020 aa)
NBNNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (748 aa)
BLMBLM RecQ like helicase. (1302 aa)
RFC4Replication factor C subunit 4. (362 aa)
POLE2DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (527 aa)
BRCA2BRCA2 DNA repair associated. (3385 aa)
MEIOBMeiosis specific with OB-fold. (476 aa)
GEN1GEN1 Holliday junction 5' flap endonuclease. (949 aa)
BRIP1Helicase ATP-binding domain-containing protein. (1189 aa)
RFC2Replication factor C subunit 2. (352 aa)
POLEDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2285 aa)
RFC3Replication factor C subunit 3. (356 aa)
RFC1Replication factor C subunit 1. (1145 aa)
ATMNon-specific serine/threonine protein kinase. (2967 aa)
TDRD3Tudor domain containing 3. (741 aa)
RAD51CRAD51 paralog C. (330 aa)
CHEK1Checkpoint kinase 1. (435 aa)
EXO1Exonuclease 1. (808 aa)
BARD1BRCA1 associated RING domain 1. (789 aa)
DNA2DNA replication helicase/nuclease 2. (1030 aa)
RAD51BRAD51 paralog B. (595 aa)
KAT7Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (611 aa)
KXD1KxDL motif containing 1. (353 aa)
RCBTB2RCC1 and BTB domain containing protein 2. (551 aa)
POLD2DNA polymerase delta 2, accessory subunit. (554 aa)
MRE11MRE11 homolog, double strand break repair nuclease. (230 aa)
EME1Essential meiotic structure-specific endonuclease 1. (390 aa)
ENSAPLP00000022406Helicase ATP-binding domain-containing protein. (72 aa)
RECQL4RecQ like helicase 4. (693 aa)
RBBP8RB binding protein 8, endonuclease. (913 aa)
SPIDRDUF4503 domain-containing protein. (95 aa)
PALB2Partner and localizer of BRCA2. (1362 aa)
ENSAPLP00000023897Uncharacterized protein. (208 aa)
RCBTB1RCC1 and BTB domain containing protein 1. (713 aa)
POLE4DNA polymerase epsilon 4, accessory subunit. (123 aa)
XRCC3X-ray repair cross complementing 3. (426 aa)
BRCA1BRCA1 DNA repair associated. (1846 aa)
ENSAPLP00000026881Zinc-hook domain-containing protein. (1312 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (262 aa)
ENSAPLP00000029564Uncharacterized protein. (378 aa)
SLX4SLX4 structure-specific endonuclease subunit. (1881 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (685 aa)
RPA3Replication protein A3. (132 aa)
SLX1Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. (228 aa)
POLE3CBFD_NFYB_HMF domain-containing protein. (143 aa)
Your Current Organism:
Anas platyrhynchos
NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard
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