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| | RPA3 | Replication protein A3. (132 aa) |
| | RPA1 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (685 aa) |
| | RAD52 | RAD52 homolog, DNA repair protein. (420 aa) |
| | APBB2 | Amyloid beta precursor protein binding family B member 2. (893 aa) |
| | SLF1 | SMC5-SMC6 complex localization factor 1. (940 aa) |
| | BRCC3 | BRCA1/BRCA2-containing complex subunit 3. (306 aa) |
| | SLX4 | SLX4 structure-specific endonuclease subunit. (1881 aa) |
| | ENSAPLP00000029576 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | ENSAPLP00000029564 | Uncharacterized protein. (378 aa) |
| | EYA4 | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (746 aa) |
| | SIRT6 | Sirtuin 6. (203 aa) |
| | TP53BP1 | Tumor protein p53 binding protein 1. (1970 aa) |
| | TMEM182 | Transmembrane protein 182. (189 aa) |
| | XRCC4 | X-ray repair cross complementing 4. (334 aa) |
| | ENSAPLP00000028423 | Uncharacterized protein; Belongs to the histone H2B family. (122 aa) |
| | ENSAPLP00000028415 | XRCC1_N domain-containing protein. (202 aa) |
| | SLC23A3 | Uncharacterized protein. (653 aa) |
| | ATRIP | ATR interacting protein. (1045 aa) |
| | ENSAPLP00000028245 | Uncharacterized protein. (71 aa) |
| | PCNA | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (262 aa) |
| | TIMELESS | Timeless circadian regulator. (1151 aa) |
| | ENSAPLP00000026997 | Uncharacterized protein; Belongs to the histone H2B family. (145 aa) |
| | CNPPD1 | Cyclin Pas1/PHO80 domain containing 1. (379 aa) |
| | ENSAPLP00000026881 | Zinc-hook domain-containing protein. (1312 aa) |
| | BRCA1 | BRCA1 DNA repair associated. (1846 aa) |
| | XRCC3 | X-ray repair cross complementing 3. (426 aa) |
| | POLE4 | DNA polymerase epsilon 4, accessory subunit. (123 aa) |
| | BAZ1B | Bromodomain adjacent to zinc finger domain 1B. (1487 aa) |
| | RNF169 | Ring finger protein 169. (458 aa) |
| | UIMC1 | Ubiquitin interaction motif containing 1. (812 aa) |
| | RIF1 | Replication timing regulatory factor 1. (2307 aa) |
| | RFC4 | Replication factor C subunit 4. (362 aa) |
| | POLE2 | DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (527 aa) |
| | BRCA2 | BRCA2 DNA repair associated. (3385 aa) |
| | CDCA7 | Cell division cycle associated 7. (239 aa) |
| | MEIOB | Meiosis specific with OB-fold. (476 aa) |
| | GEN1 | GEN1 Holliday junction 5' flap endonuclease. (949 aa) |
| | U3IM44_ANAPP | Uncharacterized protein. (252 aa) |
| | LIG3 | DNA ligase. (980 aa) |
| | BRIP1 | Helicase ATP-binding domain-containing protein. (1189 aa) |
| | RFC2 | Replication factor C subunit 2. (352 aa) |
| | H2BE1 | Histone H2B; Belongs to the histone H2B family. (162 aa) |
| | CHEK2 | Checkpoint kinase 2. (524 aa) |
| | CCNA1 | Cyclin A1; Belongs to the cyclin family. (339 aa) |
| | TOPBP1 | DNA topoisomerase II binding protein 1. (1469 aa) |
| | POLE | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2285 aa) |
| | POLL | DNA polymerase lambda; Belongs to the DNA polymerase type-X family. (618 aa) |
| | KPNA2 | Importin subunit alpha; Belongs to the importin alpha family. (529 aa) |
| | RFC3 | Replication factor C subunit 3. (356 aa) |
| | CDK3 | Cyclin dependent kinase 3; Belongs to the protein kinase superfamily. (305 aa) |
| | RMI2 | RecQ mediated genome instability 2. (139 aa) |
| | POLH | DNA polymerase eta. (679 aa) |
| | RMI1 | RecQ mediated genome instability 1. (619 aa) |
| | LIG4 | DNA ligase. (909 aa) |
| | FEN1 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (391 aa) |
| | U3I2H1_ANAPP | Uncharacterized protein. (1351 aa) |
| | U3I2I6_ANAPP | Protein kinase domain-containing protein. (184 aa) |
| | RPA2 | Replication protein A2. (269 aa) |
| | PRKDC | Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4136 aa) |
| | RAD51AP1 | RAD51 associated protein 1. (400 aa) |
| | RFC5 | Replication factor C subunit 5. (211 aa) |
| | KDM4A | Uncharacterized protein. (1058 aa) |
| | HERC2 | HECT and RLD domain containing E3 ubiquitin protein ligase 2. (4828 aa) |
| | RAD51 | DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa) |
| | XRCC6 | X-ray repair cross complementing 6. (617 aa) |
| | BABAM2 | BRISC and BRCA1 A complex member 2. (397 aa) |
| | XRCC2 | X-ray repair cross complementing 2. (369 aa) |
| | POLK | DNA polymerase kappa. (866 aa) |
| | CCNA2 | Cyclin A2; Belongs to the cyclin family. (390 aa) |
| | POLD3 | Uncharacterized protein. (464 aa) |
| | RPS27A | Ubiquitin-like domain-containing protein. (156 aa) |
| | DCLRE1C | DNA cross-link repair 1C. (716 aa) |
| | RAD17 | RAD17 checkpoint clamp loader component. (689 aa) |
| | TOP3A | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1020 aa) |
| | NBN | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (748 aa) |
| | HUS1 | Checkpoint protein; Belongs to the HUS1 family. (277 aa) |
| | RAD1 | RAD1 checkpoint DNA exonuclease. (281 aa) |
| | RFC1 | Replication factor C subunit 1. (1145 aa) |
| | KPNA7 | Karyopherin subunit alpha 7. (274 aa) |
| | PIAS4 | Protein inhibitor of activated STAT 4. (485 aa) |
| | ABRAXAS1 | Abraxas 1, BRCA1 A complex subunit. (405 aa) |
| | XRCC5 | X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. (725 aa) |
| | ATM | Non-specific serine/threonine protein kinase. (2967 aa) |
| | PARP1 | Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (992 aa) |
| | TDRD3 | Tudor domain containing 3. (741 aa) |
| | RAD51C | RAD51 paralog C. (330 aa) |
| | RNF8 | E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (612 aa) |
| | POLQ | Uncharacterized protein. (2433 aa) |
| | U3J5I9_ANAPP | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (156 aa) |
| | CHEK1 | Checkpoint kinase 1. (435 aa) |
| | EXO1 | Exonuclease 1. (808 aa) |
| | RNF168 | E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and ubiquitinates histone H2A and H2AX, leading to amplify the RNF8-dependent H2A ubiquitination and promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recrui [...] (609 aa) |
| | SIRT7 | Sirtuin 7. (408 aa) |
| | TIPIN | TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (284 aa) |
| | BARD1 | BRCA1 associated RING domain 1. (789 aa) |
| | TDP1 | Tyrosyl-DNA phosphodiesterase 1. (543 aa) |
| | DNA2 | DNA replication helicase/nuclease 2. (1030 aa) |
| | UBE2I | Ubiquitin conjugating enzyme E2 I; Belongs to the ubiquitin-conjugating enzyme family. (158 aa) |
| | ENSAPLP00000017036 | Uncharacterized protein. (36 aa) |
| | TDP2 | Tyrosyl-DNA phosphodiesterase 2. (439 aa) |
| | ATR | Uncharacterized protein. (125 aa) |
| | RAD51B | RAD51 paralog B. (595 aa) |
| | MAPK8 | Mitogen-activated protein kinase. (384 aa) |
| | ENSAPLP00000018477 | Metallophos domain-containing protein. (73 aa) |
| | ERCC1 | ERCC excision repair 1, endonuclease non-catalytic subunit. (211 aa) |
| | KAT7 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (611 aa) |
| | KXD1 | KxDL motif containing 1. (353 aa) |
| | RCBTB2 | RCC1 and BTB domain containing protein 2. (551 aa) |
| | ENSAPLP00000020417 | Uncharacterized protein. (288 aa) |
| | ENSAPLP00000020501 | DEAD domain-containing protein. (162 aa) |
| | UBE2V2 | Ubiquitin conjugating enzyme E2 V2. (144 aa) |
| | DNTT | DNA nucleotidylexotransferase; Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. (474 aa) |
| | ENSAPLP00000020801 | Uncharacterized protein. (135 aa) |
| | POLD2 | DNA polymerase delta 2, accessory subunit. (554 aa) |
| | RAD9A | RAD9 checkpoint clamp component A. (349 aa) |
| | MRE11 | MRE11 homolog, double strand break repair nuclease. (230 aa) |
| | EME1 | Essential meiotic structure-specific endonuclease 1. (390 aa) |
| | ENSAPLP00000022406 | Helicase ATP-binding domain-containing protein. (72 aa) |
| | RECQL4 | RecQ like helicase 4. (693 aa) |
| | ENSAPLP00000022612 | Uncharacterized protein. (133 aa) |
| | SUMO1 | Small ubiquitin like modifier 1. (242 aa) |
| | EYA2 | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (557 aa) |
| | ABL1 | ABL proto-oncogene 1, non-receptor tyrosine kinase. (610 aa) |
| | SMARCA5 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5. (1017 aa) |
| | RBBP8 | RB binding protein 8, endonuclease. (913 aa) |
| | SPIDR | DUF4503 domain-containing protein. (95 aa) |
| | POLN | DNA polymerase nu. (699 aa) |
| | PALB2 | Partner and localizer of BRCA2. (1362 aa) |
| | NSD2 | Nuclear receptor binding SET domain protein 2. (1394 aa) |
| | ENSAPLP00000023897 | Uncharacterized protein. (208 aa) |
| | EYA3 | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (577 aa) |
| | RCBTB1 | RCC1 and BTB domain containing protein 1. (713 aa) |
| | PPP4R2 | Protein phosphatase 4 regulatory subunit 2. (528 aa) |
| | BLM | BLM RecQ like helicase. (1302 aa) |
| | ENSAPLP00000032945 | Uncharacterized protein. (69 aa) |
| | KPNA7-2 | IBB domain-containing protein. (77 aa) |
| | PWWP2A | PWWP domain-containing protein. (208 aa) |
| | EYA1 | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (839 aa) |
| | EXD2 | Exonuclease 3'-5' domain containing 2. (767 aa) |
| | POLE3 | CBFD_NFYB_HMF domain-containing protein. (143 aa) |
| | PAXIP1 | PAX interacting protein 1. (1083 aa) |
| | ENSAPLP00000031941 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | SLX1 | Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. (228 aa) |
| | KDM4B | Lysine demethylase 4B. (1156 aa) |
| | ENSAPLP00000031478 | PARP-type domain-containing protein. (95 aa) |
| | PARP3 | Poly [ADP-ribose] polymerase. (729 aa) |
| | APBB1 | Amyloid beta precursor protein binding family B member 1. (952 aa) |
| | ENSAPLP00000031212 | SH2 domain-containing protein. (71 aa) |
