STRINGSTRING
LIG4 LIG4 PRKDC PRKDC HERC2 HERC2 XRCC6 XRCC6 BABAM2 BABAM2 DCLRE1C DCLRE1C NBN NBN RIF1 RIF1 U3IM44_ANAPP U3IM44_ANAPP H2BE1 H2BE1 POLL POLL PIAS4 PIAS4 ABRAXAS1 ABRAXAS1 XRCC5 XRCC5 ATM ATM RNF8 RNF8 U3J5I9_ANAPP U3J5I9_ANAPP RNF168 RNF168 BARD1 BARD1 TDP1 TDP1 TDP2 TDP2 KAT7 KAT7 ENSAPLP00000020417 ENSAPLP00000020417 UBE2V2 UBE2V2 DNTT DNTT ENSAPLP00000020801 ENSAPLP00000020801 MRE11 MRE11 NSD2 NSD2 UIMC1 UIMC1 RNF169 RNF169 BRCA1 BRCA1 ENSAPLP00000026881 ENSAPLP00000026881 CNPPD1 CNPPD1 ENSAPLP00000026997 ENSAPLP00000026997 ENSAPLP00000028245 ENSAPLP00000028245 SLC23A3 SLC23A3 ENSAPLP00000028423 ENSAPLP00000028423 XRCC4 XRCC4 TMEM182 TMEM182 TP53BP1 TP53BP1 ENSAPLP00000029576 ENSAPLP00000029576 BRCC3 BRCC3 ENSAPLP00000031941 ENSAPLP00000031941 PAXIP1 PAXIP1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LIG4DNA ligase. (909 aa)
PRKDCProtein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4136 aa)
HERC2HECT and RLD domain containing E3 ubiquitin protein ligase 2. (4828 aa)
XRCC6X-ray repair cross complementing 6. (617 aa)
BABAM2BRISC and BRCA1 A complex member 2. (397 aa)
DCLRE1CDNA cross-link repair 1C. (716 aa)
NBNNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (748 aa)
RIF1Replication timing regulatory factor 1. (2307 aa)
U3IM44_ANAPPUncharacterized protein. (252 aa)
H2BE1Histone H2B; Belongs to the histone H2B family. (162 aa)
POLLDNA polymerase lambda; Belongs to the DNA polymerase type-X family. (618 aa)
PIAS4Protein inhibitor of activated STAT 4. (485 aa)
ABRAXAS1Abraxas 1, BRCA1 A complex subunit. (405 aa)
XRCC5X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. (725 aa)
ATMNon-specific serine/threonine protein kinase. (2967 aa)
RNF8E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (612 aa)
U3J5I9_ANAPPUBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (156 aa)
RNF168E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and ubiquitinates histone H2A and H2AX, leading to amplify the RNF8-dependent H2A ubiquitination and promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recrui [...] (609 aa)
BARD1BRCA1 associated RING domain 1. (789 aa)
TDP1Tyrosyl-DNA phosphodiesterase 1. (543 aa)
TDP2Tyrosyl-DNA phosphodiesterase 2. (439 aa)
KAT7Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (611 aa)
ENSAPLP00000020417Uncharacterized protein. (288 aa)
UBE2V2Ubiquitin conjugating enzyme E2 V2. (144 aa)
DNTTDNA nucleotidylexotransferase; Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. (474 aa)
ENSAPLP00000020801Uncharacterized protein. (135 aa)
MRE11MRE11 homolog, double strand break repair nuclease. (230 aa)
NSD2Nuclear receptor binding SET domain protein 2. (1394 aa)
UIMC1Ubiquitin interaction motif containing 1. (812 aa)
RNF169Ring finger protein 169. (458 aa)
BRCA1BRCA1 DNA repair associated. (1846 aa)
ENSAPLP00000026881Zinc-hook domain-containing protein. (1312 aa)
CNPPD1Cyclin Pas1/PHO80 domain containing 1. (379 aa)
ENSAPLP00000026997Uncharacterized protein; Belongs to the histone H2B family. (145 aa)
ENSAPLP00000028245Uncharacterized protein. (71 aa)
SLC23A3Uncharacterized protein. (653 aa)
ENSAPLP00000028423Uncharacterized protein; Belongs to the histone H2B family. (122 aa)
XRCC4X-ray repair cross complementing 4. (334 aa)
TMEM182Transmembrane protein 182. (189 aa)
TP53BP1Tumor protein p53 binding protein 1. (1970 aa)
ENSAPLP00000029576Histone H2B; Belongs to the histone H2B family. (126 aa)
BRCC3BRCA1/BRCA2-containing complex subunit 3. (306 aa)
ENSAPLP00000031941Histone H2B; Belongs to the histone H2B family. (126 aa)
PAXIP1PAX interacting protein 1. (1083 aa)
Your Current Organism:
Anas platyrhynchos
NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard
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