STRINGSTRING
MAPK8 MAPK8 KPNA7-2 KPNA7-2 PWWP2A PWWP2A EYA1 EYA1 ENSAPLP00000031941 ENSAPLP00000031941 KDM4B KDM4B APBB1 APBB1 ENSAPLP00000031212 ENSAPLP00000031212 APBB2 APBB2 BRCC3 BRCC3 ENSAPLP00000029576 ENSAPLP00000029576 EYA4 EYA4 TP53BP1 TP53BP1 ENSAPLP00000028423 ENSAPLP00000028423 ENSAPLP00000028245 ENSAPLP00000028245 ENSAPLP00000026997 ENSAPLP00000026997 ENSAPLP00000026881 ENSAPLP00000026881 BRCA1 BRCA1 BAZ1B BAZ1B RNF169 RNF169 UIMC1 UIMC1 EYA3 EYA3 ENSAPLP00000023897 ENSAPLP00000023897 NSD2 NSD2 SMARCA5 SMARCA5 ABL1 ABL1 EYA2 EYA2 SUMO1 SUMO1 MRE11 MRE11 ENSAPLP00000020801 ENSAPLP00000020801 UBE2V2 UBE2V2 ENSAPLP00000020417 ENSAPLP00000020417 KXD1 KXD1 KAT7 KAT7 U3I2I6_ANAPP U3I2I6_ANAPP KDM4A KDM4A HERC2 HERC2 BABAM2 BABAM2 RPS27A RPS27A NBN NBN H2BE1 H2BE1 CHEK2 CHEK2 KPNA2 KPNA2 KPNA7 KPNA7 PIAS4 PIAS4 ABRAXAS1 ABRAXAS1 ATM ATM RNF8 RNF8 U3J5I9_ANAPP U3J5I9_ANAPP RNF168 RNF168 BARD1 BARD1 UBE2I UBE2I
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAPK8Mitogen-activated protein kinase. (384 aa)
KPNA7-2IBB domain-containing protein. (77 aa)
PWWP2APWWP domain-containing protein. (208 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (839 aa)
ENSAPLP00000031941Histone H2B; Belongs to the histone H2B family. (126 aa)
KDM4BLysine demethylase 4B. (1156 aa)
APBB1Amyloid beta precursor protein binding family B member 1. (952 aa)
ENSAPLP00000031212SH2 domain-containing protein. (71 aa)
APBB2Amyloid beta precursor protein binding family B member 2. (893 aa)
BRCC3BRCA1/BRCA2-containing complex subunit 3. (306 aa)
ENSAPLP00000029576Histone H2B; Belongs to the histone H2B family. (126 aa)
EYA4Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (746 aa)
TP53BP1Tumor protein p53 binding protein 1. (1970 aa)
ENSAPLP00000028423Uncharacterized protein; Belongs to the histone H2B family. (122 aa)
ENSAPLP00000028245Uncharacterized protein. (71 aa)
ENSAPLP00000026997Uncharacterized protein; Belongs to the histone H2B family. (145 aa)
ENSAPLP00000026881Zinc-hook domain-containing protein. (1312 aa)
BRCA1BRCA1 DNA repair associated. (1846 aa)
BAZ1BBromodomain adjacent to zinc finger domain 1B. (1487 aa)
RNF169Ring finger protein 169. (458 aa)
UIMC1Ubiquitin interaction motif containing 1. (812 aa)
EYA3Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (577 aa)
ENSAPLP00000023897Uncharacterized protein. (208 aa)
NSD2Nuclear receptor binding SET domain protein 2. (1394 aa)
SMARCA5SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5. (1017 aa)
ABL1ABL proto-oncogene 1, non-receptor tyrosine kinase. (610 aa)
EYA2Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (557 aa)
SUMO1Small ubiquitin like modifier 1. (242 aa)
MRE11MRE11 homolog, double strand break repair nuclease. (230 aa)
ENSAPLP00000020801Uncharacterized protein. (135 aa)
UBE2V2Ubiquitin conjugating enzyme E2 V2. (144 aa)
ENSAPLP00000020417Uncharacterized protein. (288 aa)
KXD1KxDL motif containing 1. (353 aa)
KAT7Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (611 aa)
U3I2I6_ANAPPProtein kinase domain-containing protein. (184 aa)
KDM4AUncharacterized protein. (1058 aa)
HERC2HECT and RLD domain containing E3 ubiquitin protein ligase 2. (4828 aa)
BABAM2BRISC and BRCA1 A complex member 2. (397 aa)
RPS27AUbiquitin-like domain-containing protein. (156 aa)
NBNNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (748 aa)
H2BE1Histone H2B; Belongs to the histone H2B family. (162 aa)
CHEK2Checkpoint kinase 2. (524 aa)
KPNA2Importin subunit alpha; Belongs to the importin alpha family. (529 aa)
KPNA7Karyopherin subunit alpha 7. (274 aa)
PIAS4Protein inhibitor of activated STAT 4. (485 aa)
ABRAXAS1Abraxas 1, BRCA1 A complex subunit. (405 aa)
ATMNon-specific serine/threonine protein kinase. (2967 aa)
RNF8E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (612 aa)
U3J5I9_ANAPPUBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (156 aa)
RNF168E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and ubiquitinates histone H2A and H2AX, leading to amplify the RNF8-dependent H2A ubiquitination and promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recrui [...] (609 aa)
BARD1BRCA1 associated RING domain 1. (789 aa)
UBE2IUbiquitin conjugating enzyme E2 I; Belongs to the ubiquitin-conjugating enzyme family. (158 aa)
Your Current Organism:
Anas platyrhynchos
NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard
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