(26 nodes) (2010) Sensors of the innate immune system: their link to rheumatic diseases. network (Anas platyrhynchos)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	IL6	Uncharacterized protein. (350 aa)
	IRAK4	Interleukin 1 receptor associated kinase 4. (541 aa)
	HMGB1	High mobility group box 1. (281 aa)
	SIGIRR	Single Ig and TIR domain containing. (454 aa)
	MYD88	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (311 aa)
	ENSAPLP00000028410	Uncharacterized protein. (157 aa)
	PSTPIP1	Proline-serine-threonine phosphatase interacting protein 1. (406 aa)
	PSTPIP2	Proline-serine-threonine phosphatase interacting protein 2. (319 aa)
	CALR	Calreticulin. (531 aa)
	ZAP70	Tyrosine-protein kinase. (607 aa)
	TLR7	Toll like receptor 7; Belongs to the Toll-like receptor family. (1089 aa)
	PTPN6	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (607 aa)
	IL18	Interleukin-18. (197 aa)
	IRF5	IRF-3 domain-containing protein. (174 aa)
	TLR3	Toll like receptor 3; Belongs to the Toll-like receptor family. (914 aa)
	TYRO3	TYRO3 protein tyrosine kinase. (960 aa)
	CALR3	Calreticulin. (389 aa)
	TLR2	Toll like receptor 2; Belongs to the Toll-like receptor family. (713 aa)
	TLR4	Toll like receptor 4. (843 aa)
	CTSS	Cathepsin S; Belongs to the peptidase C1 family. (330 aa)
	CTSK	Cathepsin K; Belongs to the peptidase C1 family. (311 aa)
	IFNG	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (164 aa)
	ADIPOQ	Adiponectin, C1Q and collagen domain containing. (245 aa)
	SAMHD1	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1. (573 aa)
	U3J1K3_ANAPP	Uncharacterized protein; Belongs to the peptidase C14A family. (284 aa)
	CD4	Ig-like domain-containing protein. (264 aa)

Your Current Organism:

Anas platyrhynchos

NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADIPOQ	CALR	ENSAPLP00000013340	ENSAPLP00000032112	Adiponectin, C1Q and collagen domain containing.	Calreticulin.	0.492
ADIPOQ	CALR3	ENSAPLP00000013340	ENSAPLP00000010449	Adiponectin, C1Q and collagen domain containing.	Calreticulin.	0.461
ADIPOQ	IL6	ENSAPLP00000013340	ENSAPLP00000020478	Adiponectin, C1Q and collagen domain containing.	Uncharacterized protein.	0.760
CALR	ADIPOQ	ENSAPLP00000032112	ENSAPLP00000013340	Calreticulin.	Adiponectin, C1Q and collagen domain containing.	0.492
CALR	CD4	ENSAPLP00000032112	ENSAPLP00000018005	Calreticulin.	Ig-like domain-containing protein.	0.512
CALR	HMGB1	ENSAPLP00000032112	ENSAPLP00000023852	Calreticulin.	High mobility group box 1.	0.756
CALR3	ADIPOQ	ENSAPLP00000010449	ENSAPLP00000013340	Calreticulin.	Adiponectin, C1Q and collagen domain containing.	0.461
CALR3	CD4	ENSAPLP00000010449	ENSAPLP00000018005	Calreticulin.	Ig-like domain-containing protein.	0.508
CALR3	HMGB1	ENSAPLP00000010449	ENSAPLP00000023852	Calreticulin.	High mobility group box 1.	0.744
CD4	CALR	ENSAPLP00000018005	ENSAPLP00000032112	Ig-like domain-containing protein.	Calreticulin.	0.512
CD4	CALR3	ENSAPLP00000018005	ENSAPLP00000010449	Ig-like domain-containing protein.	Calreticulin.	0.508
CD4	CTSS	ENSAPLP00000018005	ENSAPLP00000012421	Ig-like domain-containing protein.	Cathepsin S; Belongs to the peptidase C1 family.	0.513
CD4	ENSAPLP00000028410	ENSAPLP00000018005	ENSAPLP00000028410	Ig-like domain-containing protein.	Uncharacterized protein.	0.632
CD4	HMGB1	ENSAPLP00000018005	ENSAPLP00000023852	Ig-like domain-containing protein.	High mobility group box 1.	0.530
CD4	IFNG	ENSAPLP00000018005	ENSAPLP00000012661	Ig-like domain-containing protein.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.958
CD4	IL18	ENSAPLP00000018005	ENSAPLP00000005562	Ig-like domain-containing protein.	Interleukin-18.	0.648
CD4	IL6	ENSAPLP00000018005	ENSAPLP00000020478	Ig-like domain-containing protein.	Uncharacterized protein.	0.961
CD4	IRF5	ENSAPLP00000018005	ENSAPLP00000005791	Ig-like domain-containing protein.	IRF-3 domain-containing protein.	0.408
CD4	MYD88	ENSAPLP00000018005	ENSAPLP00000028214	Ig-like domain-containing protein.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.801
CD4	PTPN6	ENSAPLP00000018005	ENSAPLP00000004482	Ig-like domain-containing protein.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.607