node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CD4 | CFTR | ENSAPLP00000018005 | ENSAPLP00000011016 | Ig-like domain-containing protein. | Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. | 0.435 |
CD4 | IFNG | ENSAPLP00000018005 | ENSAPLP00000012661 | Ig-like domain-containing protein. | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. | 0.958 |
CD4 | IL10 | ENSAPLP00000018005 | ENSAPLP00000015242 | Ig-like domain-containing protein. | Interleukin 10. | 0.959 |
CD4 | IL21 | ENSAPLP00000018005 | ENSAPLP00000006533 | Ig-like domain-containing protein. | Interleukin; Belongs to the IL-15/IL-21 family. | 0.764 |
CD4 | TLR2 | ENSAPLP00000018005 | ENSAPLP00000011131 | Ig-like domain-containing protein. | Toll like receptor 2; Belongs to the Toll-like receptor family. | 0.577 |
CFTR | CD4 | ENSAPLP00000011016 | ENSAPLP00000018005 | Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. | Ig-like domain-containing protein. | 0.435 |
ENSAPLP00000029576 | U3I833_ANAPP | ENSAPLP00000029576 | ENSAPLP00000003404 | Histone H2B; Belongs to the histone H2B family. | Histone H3; Belongs to the histone H3 family. | 0.932 |
ENSAPLP00000031941 | U3I833_ANAPP | ENSAPLP00000031941 | ENSAPLP00000003404 | Histone H2B; Belongs to the histone H2B family. | Histone H3; Belongs to the histone H3 family. | 0.940 |
H2BE1 | U3I833_ANAPP | ENSAPLP00000009306 | ENSAPLP00000003404 | Histone H2B; Belongs to the histone H2B family. | Histone H3; Belongs to the histone H3 family. | 0.923 |
IFNG | CD4 | ENSAPLP00000012661 | ENSAPLP00000018005 | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. | Ig-like domain-containing protein. | 0.958 |
IFNG | IL10 | ENSAPLP00000012661 | ENSAPLP00000015242 | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. | Interleukin 10. | 0.974 |
IFNG | IL21 | ENSAPLP00000012661 | ENSAPLP00000006533 | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. | Interleukin; Belongs to the IL-15/IL-21 family. | 0.774 |
IFNG | TLR2 | ENSAPLP00000012661 | ENSAPLP00000011131 | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. | Toll like receptor 2; Belongs to the Toll-like receptor family. | 0.495 |
IL10 | CD4 | ENSAPLP00000015242 | ENSAPLP00000018005 | Interleukin 10. | Ig-like domain-containing protein. | 0.959 |
IL10 | IFNG | ENSAPLP00000015242 | ENSAPLP00000012661 | Interleukin 10. | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. | 0.974 |
IL10 | IL21 | ENSAPLP00000015242 | ENSAPLP00000006533 | Interleukin 10. | Interleukin; Belongs to the IL-15/IL-21 family. | 0.708 |
IL10 | TLR2 | ENSAPLP00000015242 | ENSAPLP00000011131 | Interleukin 10. | Toll like receptor 2; Belongs to the Toll-like receptor family. | 0.607 |
IL21 | CD4 | ENSAPLP00000006533 | ENSAPLP00000018005 | Interleukin; Belongs to the IL-15/IL-21 family. | Ig-like domain-containing protein. | 0.764 |
IL21 | IFNG | ENSAPLP00000006533 | ENSAPLP00000012661 | Interleukin; Belongs to the IL-15/IL-21 family. | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. | 0.774 |
IL21 | IL10 | ENSAPLP00000006533 | ENSAPLP00000015242 | Interleukin; Belongs to the IL-15/IL-21 family. | Interleukin 10. | 0.708 |