(16 nodes) (2014) Bioreactor technologies to support liver function in vitro. network (Anas platyrhynchos)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ALB	Uncharacterized protein. (592 aa)
	VWF	Von Willebrand factor. (2756 aa)
	ABCC1	ATP binding cassette subfamily C member 1. (1518 aa)
	CYP7A1	Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family. (512 aa)
	TLR3	Toll like receptor 3; Belongs to the Toll-like receptor family. (914 aa)
	IL10	Interleukin 10. (177 aa)
	GCG	Glucagon. (206 aa)
	TLR2	Toll like receptor 2; Belongs to the Toll-like receptor family. (713 aa)
	TLR4	Toll like receptor 4. (843 aa)
	IFNG	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (164 aa)
	TLR5	TIR domain-containing protein; Belongs to the Toll-like receptor family. (878 aa)
	INS	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (141 aa)
	ABCB1	Uncharacterized protein. (1221 aa)
	GPT2	Glutamic--pyruvic transaminase 2. (423 aa)
	IL6	Uncharacterized protein. (350 aa)
	HMGB1	High mobility group box 1. (281 aa)

Your Current Organism:

Anas platyrhynchos

NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABCB1	ABCC1	ENSAPLP00000014965	ENSAPLP00000007321	Uncharacterized protein.	ATP binding cassette subfamily C member 1.	0.473
ABCC1	ABCB1	ENSAPLP00000007321	ENSAPLP00000014965	ATP binding cassette subfamily C member 1.	Uncharacterized protein.	0.473
ABCC1	HMGB1	ENSAPLP00000007321	ENSAPLP00000023852	ATP binding cassette subfamily C member 1.	High mobility group box 1.	0.451
ALB	GCG	ENSAPLP00000025530	ENSAPLP00000010047	Uncharacterized protein.	Glucagon.	0.485
ALB	GPT2	ENSAPLP00000025530	ENSAPLP00000009553	Uncharacterized protein.	Glutamic--pyruvic transaminase 2.	0.802
ALB	IFNG	ENSAPLP00000025530	ENSAPLP00000012661	Uncharacterized protein.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.697
ALB	IL10	ENSAPLP00000025530	ENSAPLP00000015242	Uncharacterized protein.	Interleukin 10.	0.720
ALB	IL6	ENSAPLP00000025530	ENSAPLP00000020478	Uncharacterized protein.	Uncharacterized protein.	0.803
ALB	INS	ENSAPLP00000025530	ENSAPLP00000012854	Uncharacterized protein.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.855
ALB	TLR4	ENSAPLP00000025530	ENSAPLP00000012401	Uncharacterized protein.	Toll like receptor 4.	0.601
ALB	VWF	ENSAPLP00000025530	ENSAPLP00000002360	Uncharacterized protein.	Von Willebrand factor.	0.597
GCG	ALB	ENSAPLP00000010047	ENSAPLP00000025530	Glucagon.	Uncharacterized protein.	0.485
GCG	IL6	ENSAPLP00000010047	ENSAPLP00000020478	Glucagon.	Uncharacterized protein.	0.595
GCG	INS	ENSAPLP00000010047	ENSAPLP00000012854	Glucagon.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.940
GPT2	ALB	ENSAPLP00000009553	ENSAPLP00000025530	Glutamic--pyruvic transaminase 2.	Uncharacterized protein.	0.802
GPT2	IL6	ENSAPLP00000009553	ENSAPLP00000020478	Glutamic--pyruvic transaminase 2.	Uncharacterized protein.	0.423
GPT2	INS	ENSAPLP00000009553	ENSAPLP00000012854	Glutamic--pyruvic transaminase 2.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.459
HMGB1	ABCC1	ENSAPLP00000023852	ENSAPLP00000007321	High mobility group box 1.	ATP binding cassette subfamily C member 1.	0.451
HMGB1	IL10	ENSAPLP00000023852	ENSAPLP00000015242	High mobility group box 1.	Interleukin 10.	0.511
HMGB1	IL6	ENSAPLP00000023852	ENSAPLP00000020478	High mobility group box 1.	Uncharacterized protein.	0.738