(104 nodes) (2015) Transcriptomic analyses of regenerating adult feathers in chicken. network (Anas platyrhynchos)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PARD6A	Par-6 family cell polarity regulator alpha. (357 aa)
	FGF22	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (367 aa)
	EPAS1	Endothelial PAS domain protein 1. (876 aa)
	CD44	CD44 molecule (Indian blood group). (645 aa)
	TUBB3	Uncharacterized protein; Belongs to the tubulin family. (200 aa)
	TYRP1	Tyrosinase related protein 1. (529 aa)
	PLA2G4A	Phospholipase A2. (749 aa)
	EDNRA	Endothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (421 aa)
	WNT5A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
	JAK1	Tyrosine-protein kinase. (1152 aa)
	EGF	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1182 aa)
	FGF9	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	WNT7B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
	FGF13	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (245 aa)
	TUBA4A	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (430 aa)
	FGF18	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (276 aa)
	JAG1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1225 aa)
	WWOX	WW domain containing oxidoreductase. (402 aa)
	PRKAR1A	Protein kinase cAMP-dependent type I regulatory subunit alpha. (382 aa)
	PRKCI	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (599 aa)
	SP3	Sp3 transcription factor. (735 aa)
	TJP1	Tight junction protein 1; Belongs to the MAGUK family. (1715 aa)
	TWSG1	Twisted gastrulation BMP signaling modulator 1. (225 aa)
	ADRA1A	Adrenoceptor alpha 1A. (442 aa)
	HOXC13	Homeobox C13. (203 aa)
	SHH	Sonic hedgehog signaling molecule. (391 aa)
	FGF2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (105 aa)
	FGF1	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
	FGF16	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (230 aa)
	MYH11	Myosin heavy chain 11; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1979 aa)
	ACTA2	Actin alpha 2, smooth muscle. (382 aa)
	MYLK	Myosin light chain kinase. (1889 aa)
	RASA1	RAS p21 protein activator 1. (992 aa)
	GSN	Gelsolin. (778 aa)
	PLXNB2	Plexin B2. (1845 aa)
	PPARD	Peroxisome proliferator activated receptor delta. (381 aa)
	MAPK11	Mitogen-activated protein kinase. (361 aa)
	FGF3	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (224 aa)
	FGF17	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
	FGF7	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
	CDH2	Cadherin 2; Cadherins are calcium-dependent cell adhesion proteins. (912 aa)
	FGF19	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (226 aa)
	MTMR2	Myotubularin related protein 2. (645 aa)
	RAB8B	RAB8B, member RAS oncogene family. (339 aa)
	ITPR3	Inositol 1,4,5-trisphosphate receptor type 3. (2613 aa)
	EGFR	Receptor protein-tyrosine kinase. (1219 aa)
	FGF6	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (182 aa)
	PMEPA1	Prostate transmembrane protein, androgen induced 1. (202 aa)
	HIF1A	Hypoxia inducible factor 1 subunit alpha. (770 aa)
	FZD2	Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (581 aa)
	GJA5	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (369 aa)
	NOG	Noggin; Belongs to the noggin family. (223 aa)
	SOX14	HMG box domain-containing protein. (240 aa)
	FGF4	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
	SEMA5A	Semaphorin 5A. (1076 aa)
	DPYSL3	Dihydropyrimidinase like 3. (632 aa)
	PPP2R2B	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (449 aa)
	MYL4	Uncharacterized protein. (290 aa)
	GLI1	GLI family zinc finger 1. (1097 aa)
	ACTN1	Actinin alpha 1. (914 aa)
	PMEL	Premelanosome protein. (668 aa)
	RARB	Retinoic acid receptor beta. (455 aa)
	PLA2G12A	Phospholipase A2 group XIIA. (199 aa)
	TUBB4B	Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (445 aa)
	CDH3	Uncharacterized protein. (682 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (212 aa)
	INHBB	Inhibin subunit beta B. (392 aa)
	SFRP4	Secreted frizzled related protein 4. (563 aa)
	PDGFD	Platelet derived growth factor D. (577 aa)
	TJP3	Tight junction protein 3; Belongs to the MAGUK family. (760 aa)
	ACVR1	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (526 aa)
	SMAD5	Mothers against decapentaplegic homolog. (465 aa)
	MAP3K1	Mitogen-activated protein kinase kinase kinase 1. (1525 aa)
	FGF14	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (247 aa)
	FGF8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (200 aa)
	HMGA2	Uncharacterized protein. (202 aa)
	FGF12	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (243 aa)
	SFRP2	Secreted frizzled related protein 2. (358 aa)
	ENSAPLP00000029488	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (502 aa)
	BMP4	Bone morphogenetic protein 4. (407 aa)
	MYL9	Myosin light chain 9. (310 aa)
	JAM3	Junctional adhesion molecule 3. (299 aa)
	FGF20	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (368 aa)
	SEMA4B	Semaphorin 4B; Belongs to the semaphorin family. (718 aa)
	FGFR2	Fibroblast growth factor receptor. (843 aa)
	RUNX2	RUNX family transcription factor 2. (510 aa)
	JUN	Jun proto-oncogene, AP-1 transcription factor subunit. (276 aa)
	TYR	Tyrosinase. (490 aa)
	PLXNA1	Plexin_cytopl domain-containing protein. (242 aa)
	INHBA	Inhibin subunit beta A. (424 aa)
	FGFR3	Fibroblast growth factor receptor. (833 aa)
	WNT3A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
	NFATC3	Nuclear factor of activated T cells 3. (1123 aa)
	SOX7	Uncharacterized protein. (558 aa)
	PLCB4	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1175 aa)
	CLDN3	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (214 aa)
	CLDN4	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (347 aa)
	CDH5	Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins. (772 aa)
	WNT2B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (385 aa)
	ARHGEF12	Rho guanine nucleotide exchange factor 12. (1548 aa)
	ITPR2	Inositol 1,4,5-trisphosphate receptor type 2. (2699 aa)
	RAMP2	Uncharacterized protein. (379 aa)
	DKK3	Dickkopf WNT signaling pathway inhibitor 3. (359 aa)
	RUNX3	Runt-related transcription factor. (417 aa)

Your Current Organism:

Anas platyrhynchos

NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTA2	ACTN1	ENSAPLP00000005669	ENSAPLP00000020134	Actin alpha 2, smooth muscle.	Actinin alpha 1.	0.482
ACTA2	ADRA1A	ENSAPLP00000005669	ENSAPLP00000007056	Actin alpha 2, smooth muscle.	Adrenoceptor alpha 1A.	0.471
ACTA2	ARHGEF12	ENSAPLP00000005669	ENSAPLP00000014871	Actin alpha 2, smooth muscle.	Rho guanine nucleotide exchange factor 12.	0.486
ACTA2	CDH5	ENSAPLP00000005669	ENSAPLP00000014408	Actin alpha 2, smooth muscle.	Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins.	0.606
ACTA2	ITPR2	ENSAPLP00000005669	ENSAPLP00000014993	Actin alpha 2, smooth muscle.	Inositol 1,4,5-trisphosphate receptor type 2.	0.410
ACTA2	MYH11	ENSAPLP00000005669	ENSAPLP00000005955	Actin alpha 2, smooth muscle.	Myosin heavy chain 11; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.991
ACTA2	MYL4	ENSAPLP00000005669	ENSAPLP00000019860	Actin alpha 2, smooth muscle.	Uncharacterized protein.	0.485
ACTA2	MYL9	ENSAPLP00000005669	ENSAPLP00000029817	Actin alpha 2, smooth muscle.	Myosin light chain 9.	0.954
ACTA2	MYLK	ENSAPLP00000005669	ENSAPLP00000005411	Actin alpha 2, smooth muscle.	Myosin light chain kinase.	0.742
ACTA2	PLA2G4A	ENSAPLP00000005669	ENSAPLP00000012880	Actin alpha 2, smooth muscle.	Phospholipase A2.	0.405
ACTA2	PLCB4	ENSAPLP00000005669	ENSAPLP00000013480	Actin alpha 2, smooth muscle.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.	0.460
ACTA2	TUBA4A	ENSAPLP00000005669	ENSAPLP00000010045	Actin alpha 2, smooth muscle.	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	0.467
ACTA2	TUBB3	ENSAPLP00000005669	ENSAPLP00000017055	Actin alpha 2, smooth muscle.	Uncharacterized protein; Belongs to the tubulin family.	0.463
ACTA2	TUBB4B	ENSAPLP00000005669	ENSAPLP00000021918	Actin alpha 2, smooth muscle.	Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	0.438
ACTN1	ACTA2	ENSAPLP00000020134	ENSAPLP00000005669	Actinin alpha 1.	Actin alpha 2, smooth muscle.	0.482
ACTN1	MTMR2	ENSAPLP00000020134	ENSAPLP00000003625	Actinin alpha 1.	Myotubularin related protein 2.	0.504
ACTN1	MYH11	ENSAPLP00000020134	ENSAPLP00000005955	Actinin alpha 1.	Myosin heavy chain 11; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.467
ACTN1	MYL4	ENSAPLP00000020134	ENSAPLP00000019860	Actinin alpha 1.	Uncharacterized protein.	0.595
ACTN1	MYLK	ENSAPLP00000020134	ENSAPLP00000005411	Actinin alpha 1.	Myosin light chain kinase.	0.560
ACVR1	BMP4	ENSAPLP00000023689	ENSAPLP00000029585	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Bone morphogenetic protein 4.	0.992