(16 nodes) (2015) Pathogenic Inflammation and Its Therapeutic Targeting in Systemic Lupus Erythematosus. network (Anas platyrhynchos)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	IL4	Uncharacterized protein. (136 aa)
	TGFB2	Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
	STAT3	Signal transducer and activator of transcription. (942 aa)
	IRF5	IRF-3 domain-containing protein. (174 aa)
	LYN	Tyrosine-protein kinase. (535 aa)
	IL18	Interleukin-18. (197 aa)
	IL15	Interleukin; Belongs to the IL-15/IL-21 family. (223 aa)
	TLR7	Toll like receptor 7; Belongs to the Toll-like receptor family. (1089 aa)
	JAK2	Tyrosine-protein kinase. (1130 aa)
	CD86	CD86 molecule. (341 aa)
	IL6	Uncharacterized protein. (350 aa)
	CD4	Ig-like domain-containing protein. (264 aa)
	IL6R	Interleukin 6 receptor. (415 aa)
	IFNG	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (164 aa)
	JAK1	Tyrosine-protein kinase. (1152 aa)
	PTPN22	Protein tyrosine phosphatase non-receptor type 22. (803 aa)

Your Current Organism:

Anas platyrhynchos

NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CD4	CD86	ENSAPLP00000018005	ENSAPLP00000026026	Ig-like domain-containing protein.	CD86 molecule.	0.966
CD4	IFNG	ENSAPLP00000018005	ENSAPLP00000012661	Ig-like domain-containing protein.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.958
CD4	IL15	ENSAPLP00000018005	ENSAPLP00000004404	Ig-like domain-containing protein.	Interleukin; Belongs to the IL-15/IL-21 family.	0.811
CD4	IL18	ENSAPLP00000018005	ENSAPLP00000005562	Ig-like domain-containing protein.	Interleukin-18.	0.648
CD4	IL4	ENSAPLP00000018005	ENSAPLP00000011598	Ig-like domain-containing protein.	Uncharacterized protein.	0.957
CD4	IL6	ENSAPLP00000018005	ENSAPLP00000020478	Ig-like domain-containing protein.	Uncharacterized protein.	0.961
CD4	IL6R	ENSAPLP00000018005	ENSAPLP00000017269	Ig-like domain-containing protein.	Interleukin 6 receptor.	0.475
CD4	IRF5	ENSAPLP00000018005	ENSAPLP00000005791	Ig-like domain-containing protein.	IRF-3 domain-containing protein.	0.408
CD4	JAK1	ENSAPLP00000018005	ENSAPLP00000011906	Ig-like domain-containing protein.	Tyrosine-protein kinase.	0.496
CD4	JAK2	ENSAPLP00000018005	ENSAPLP00000027035	Ig-like domain-containing protein.	Tyrosine-protein kinase.	0.415
CD4	LYN	ENSAPLP00000018005	ENSAPLP00000005775	Ig-like domain-containing protein.	Tyrosine-protein kinase.	0.804
CD4	PTPN22	ENSAPLP00000018005	ENSAPLP00000011618	Ig-like domain-containing protein.	Protein tyrosine phosphatase non-receptor type 22.	0.670
CD4	STAT3	ENSAPLP00000018005	ENSAPLP00000007496	Ig-like domain-containing protein.	Signal transducer and activator of transcription.	0.800
CD4	TLR7	ENSAPLP00000018005	ENSAPLP00000003630	Ig-like domain-containing protein.	Toll like receptor 7; Belongs to the Toll-like receptor family.	0.873
CD86	CD4	ENSAPLP00000026026	ENSAPLP00000018005	CD86 molecule.	Ig-like domain-containing protein.	0.966
CD86	IFNG	ENSAPLP00000026026	ENSAPLP00000012661	CD86 molecule.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.885
CD86	IL15	ENSAPLP00000026026	ENSAPLP00000004404	CD86 molecule.	Interleukin; Belongs to the IL-15/IL-21 family.	0.705
CD86	IL18	ENSAPLP00000026026	ENSAPLP00000005562	CD86 molecule.	Interleukin-18.	0.462
CD86	IL4	ENSAPLP00000026026	ENSAPLP00000011598	CD86 molecule.	Uncharacterized protein.	0.820
CD86	IL6	ENSAPLP00000026026	ENSAPLP00000020478	CD86 molecule.	Uncharacterized protein.	0.821