(11 nodes) (2017) Autophagy in Dendritic Cells and B Cells Is Critical for the Inflammatory State of TLR7-Mediated Autoimmunity. network (Anas platyrhynchos)

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Your Input:
	ATG7	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...] (735 aa)
	ATG5	Autophagy protein 5; Involved in autophagic vesicle formation. (315 aa)
	IL10	Interleukin 10. (177 aa)
	U3J1K3_ANAPP	Uncharacterized protein; Belongs to the peptidase C14A family. (284 aa)
	IFNG	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (164 aa)
	IL4	Uncharacterized protein. (136 aa)
	BCR	BCR activator of RhoGEF and GTPase. (1280 aa)
	IL18	Interleukin-18. (197 aa)
	IL6	Uncharacterized protein. (350 aa)
	TLR7	Toll like receptor 7; Belongs to the Toll-like receptor family. (1089 aa)
	BECN1	Uncharacterized protein. (452 aa)

Your Current Organism:

Anas platyrhynchos

NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATG5	ATG7	ENSAPLP00000018253	ENSAPLP00000019209	Autophagy protein 5; Involved in autophagic vesicle formation.	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...]	0.999
ATG5	BECN1	ENSAPLP00000018253	ENSAPLP00000004076	Autophagy protein 5; Involved in autophagic vesicle formation.	Uncharacterized protein.	0.982
ATG7	ATG5	ENSAPLP00000019209	ENSAPLP00000018253	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...]	Autophagy protein 5; Involved in autophagic vesicle formation.	0.999
ATG7	BECN1	ENSAPLP00000019209	ENSAPLP00000004076	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...]	Uncharacterized protein.	0.947
BECN1	ATG5	ENSAPLP00000004076	ENSAPLP00000018253	Uncharacterized protein.	Autophagy protein 5; Involved in autophagic vesicle formation.	0.982
BECN1	ATG7	ENSAPLP00000004076	ENSAPLP00000019209	Uncharacterized protein.	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...]	0.947
BECN1	IL18	ENSAPLP00000004076	ENSAPLP00000005562	Uncharacterized protein.	Interleukin-18.	0.415
IFNG	IL10	ENSAPLP00000012661	ENSAPLP00000015242	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	Interleukin 10.	0.974
IFNG	IL18	ENSAPLP00000012661	ENSAPLP00000005562	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	Interleukin-18.	0.859
IFNG	IL4	ENSAPLP00000012661	ENSAPLP00000011598	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	Uncharacterized protein.	0.958
IFNG	IL6	ENSAPLP00000012661	ENSAPLP00000020478	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	Uncharacterized protein.	0.959
IFNG	TLR7	ENSAPLP00000012661	ENSAPLP00000003630	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	Toll like receptor 7; Belongs to the Toll-like receptor family.	0.732
IFNG	U3J1K3_ANAPP	ENSAPLP00000012661	ENSAPLP00000013380	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.469
IL10	IFNG	ENSAPLP00000015242	ENSAPLP00000012661	Interleukin 10.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.974
IL10	IL18	ENSAPLP00000015242	ENSAPLP00000005562	Interleukin 10.	Interleukin-18.	0.851
IL10	IL4	ENSAPLP00000015242	ENSAPLP00000011598	Interleukin 10.	Uncharacterized protein.	0.957
IL10	IL6	ENSAPLP00000015242	ENSAPLP00000020478	Interleukin 10.	Uncharacterized protein.	0.975
IL10	TLR7	ENSAPLP00000015242	ENSAPLP00000003630	Interleukin 10.	Toll like receptor 7; Belongs to the Toll-like receptor family.	0.818
IL10	U3J1K3_ANAPP	ENSAPLP00000015242	ENSAPLP00000013380	Interleukin 10.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.685
IL18	BECN1	ENSAPLP00000005562	ENSAPLP00000004076	Interleukin-18.	Uncharacterized protein.	0.415